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dc.creatorMaljurić, Nevena
dc.creatorOtašević, Biljana
dc.creatorGolubović, Jelena
dc.creatorKrmar, Jovana
dc.creatorZečević, Mira
dc.creatorProtić, Ana
dc.date.accessioned2020-02-14T15:45:36Z
dc.date.available2020-02-14T15:45:36Z
dc.date.issued2020
dc.identifier.issn0026-265X
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3512
dc.description.abstractGreen analytical chemistry is primarily directed towards minimization of the amount of waste associated with either the sample preparation or analysis. Among different chromatographic methods, liquid chromatography is considered the least green, allowing for various possibilities for greening. Using green solvents such as ethanol or acetone in RP-HPLC, as an alternative to acetonitrile, is recently attracting an attention. Both ethanol and acetone are characterized with low toxicity, with certain drawbacks limiting their regular use in RP-HPLC. Ethanol has low eluotropic strength and causes high backpressures, while acetone shows high UV cut-off, making it unsuitable for UV/Vis detection. To overcome the existing problems, Corona Charged Aerosol Detector was employed for development of RP-HPLC methods for separation of risperidone and its structurally related impurities with either ethanol or acetone as organic modifier. The methods were optimized by experimental design methodology, while optimal conditions for separation were determined using Derringer's desirability function. Detailed assessment of 3D surface plots of Derringer's desirability function enabled selection of 0.6 mL min−1 flow rate and 20% (v/v) organic modifier content as optimal when using ethanol, while in case of acetone mobile phase flow rate was 0.8 mL min−1 and organic modifier content 17% (v/v). Methods were validated and their eco-friendly character was confirmed through Green Analytical Procedure Index (GAPI). Although both methods are ecologically acceptable, the main drawback is reflected in the fact that no recycling or another waste treatment method exist. In the end, acetone was prioritized over ethanol, due to lower health hazard and decreased amount of generated waste.en
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172033/RS//
dc.rightsrestrictedAccess
dc.sourceMicrochemical Journal
dc.subjectGreen analytical chemistry
dc.subjectCAD
dc.subjectEthanol
dc.subjectAcetone
dc.subjectRP-HPLC
dc.subjectGAPI
dc.titleA new strategy for development of eco-friendly RP-HPLC method using Corona Charged Aerosol Detector and its application for simultaneous analysis of risperidone and its related impuritiesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМаљурић, Невена; Протић, Aна; Зечевић, Мира; Крмар, Јована; Голубовић, Јелена; Оташевић, Биљана;
dc.citation.volume153
dc.citation.rankM21
dc.identifier.wos000514218800036
dc.identifier.doi10.1016/j.microc.2019.104394
dc.identifier.scopus2-s2.0-85075387127
dc.type.versionpublishedVersion


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Приказ основних података о документу