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dc.creatorNurchi, Valeria M.
dc.creatorBuha-Đorđević, Aleksandra
dc.creatorCrisponi, Guido
dc.creatorAlexander, Jan
dc.creatorBjørklund, Geir
dc.creatorAaseth, Jan
dc.date.accessioned2020-02-19T09:24:31Z
dc.date.available2020-02-19T09:24:31Z
dc.date.issued2020
dc.identifier.issn2218-273X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3518
dc.description.abstractHigh arsenic (As) levels in food and drinking water, or under some occupational conditions, can precipitate chronic toxicity and in some cases cancer. Millions of people are exposed to unacceptable amounts of As through drinking water and food. Highly exposed individuals may develop acute, subacute, or chronic signs of poisoning, characterized by skin lesions, cardiovascular symptoms, and in some cases, multi-organ failure. Inorganic arsenite(III) and organic arsenicals with the general formula R-As2+ are bound tightly to thiol groups, particularly to vicinal dithiols such as dihydrolipoic acid (DHLA), which together with some seleno-enzymes constitute vulnerable targets for the toxic action of As. In addition, R-As2+-compounds have even higher affinity to selenol groups, e.g., in thioredoxin reductase that also possesses a thiol group vicinal to the selenol. Inhibition of this and other ROS scavenging seleno-enzymes explain the oxidative stress associated with arsenic poisoning. The development of chelating agents, such as the dithiols BAL (dimercaptopropanol), DMPS (dimercapto-propanesulfonate) and DMSA (dimercaptosuccinic acid), took advantage of the fact that As had high affinity towards vicinal dithiols. Primary prevention by reducing exposure of the millions of people exposed to unacceptable As levels should be the prioritized strategy. However, in acute and subacute and even some cases with chronic As poisonings chelation treatment with therapeutic dithiols, in particular DMPS appears promising as regards alleviation of symptoms. In acute cases, initial treatment with BAL combined with DMPS should be considered.
dc.publisherMDPI AG
dc.relationSardegna for the financial support of the project RASSR79857.
dc.rightsopenAccess
dc.sourceBiomolecules
dc.subjectBAL
dc.subjectDMPS
dc.subjectArsenic
dc.subjectArsenic poisoning
dc.subjectDrinking water
dc.subjectLipoic acid
dc.titleArsenic toxicity: Molecular targets and therapeutic agents
dc.typearticle
dc.rights.licenseBY
dcterms.abstractНурцхи, Валериа М.; Буха-Ђорђевић, Aлександра; Цриспони, Гуидо; Бјøрклунд, Геир; Aасетх, Јан; Aлеxандер, Јан;
dc.citation.volume10
dc.citation.issue2
dc.identifier.wos000522138500178
dc.identifier.doi10.3390/biom10020235
dc.identifier.scopus2-s2.0-85079082895
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/7525/Arsenic_Toxicity_Molecular_pub_2020.pdf
dc.type.versionpublishedVersion


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