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dc.creatorJurišić Dukovski, Bisera
dc.creatorJuretić, Marina
dc.creatorBračko, Danka
dc.creatorRandjelović, Danijela
dc.creatorSavić, Snežana
dc.creatorCrespo Moral, Mario
dc.creatorDiebold, Yolanda
dc.creatorFilipović-Grčić, Jelena
dc.creatorGrigorov, Ivan
dc.creatorLovrić, Jasmina
dc.date.accessioned2020-02-20T13:01:59Z
dc.date.available2020-02-20T13:01:59Z
dc.date.issued2020
dc.identifier.issn0378-5173
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3523
dc.description.abstractInflammation plays a key role in dry eye disease (DED) affecting millions of people worldwide. Non-steroidal anti-inflammatory drugs (NSAIDs) can be used topically to act on the inflammatory component of DED, but their limited aqueous solubility raises formulation issues. The aim of this study was development and optimization of functional cationic nanoemulsions (NEs) for DED treatment, as a formulation approach to circumvent solubility problems, prolong drug residence at the ocular surface and stabilize the tear film. Ibuprofen was employed as the model NSAID, chitosan as the cationic agent, and lecithin as the anionic surfactant enabling chitosan incorporation. Moreover, lecithin is a mixture of phospholipids including phosphatidylcholine and phosphatidylethanolamine, two constituents of the natural tear film important for its stability. NEs were characterized in terms of droplet size, polydispersity index, zeta-potential, pH, viscosity, osmolarity, surface tension, entrapment efficiency, stability, sterilizability and in vitro release. NEs mucoadhesive properties were tested rheologically after mixing with mucin dispersion. Biocompatibility was assessed employing 3D HCE-T cell-based model and ex vivo model using porcine corneas. The results of our study pointed out the NE formulation with 0.05% (w/w) chitosan as the lead formulation with physicochemical properties adequate for ophthalmic application, mucoadhesive character and excellent biocompatibility.en
dc.publisherElsevier B.V.
dc.relationTopical nanodelivery systems funded by the University of Zagreb (Z169), the project “Modelling of the Pharmaceutical Spray Drying Process of the Emulsions in Laboratory and Pilot Scale” in collaboration with the industrial partner PLIVA Croatia Ltd.
dc.relationSpanish Government Grant RTI2018-094071-B-C21 (MCIU/AEI/FEDER, UE) (YD and MC-M).
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Pharmaceutics
dc.subjectChitosan
dc.subjectDry eye disease
dc.subjectLecithin
dc.subjectNanoemulsion
dc.subjectNSAID
dc.titleFunctional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatmenten
dc.typearticle
dc.rights.licenseARR
dcterms.abstractРандјеловић, Данијела; Брачко, Данка; Јуретић, Марина; Јуришић Дуковски, Бисера; Савић, Снежана; Ловрић, Јасмина; Григоров, Иван; Цреспо Морал, Марио; Диеболд, Yоланда; Филиповић-Грчић, Јелена;
dc.citation.volume576
dc.citation.rankM21~
dc.identifier.wos000512972500015
dc.identifier.doi10.1016/j.ijpharm.2019.118979
dc.identifier.scopus2-s2.0-85077471068
dc.type.versionpublishedVersion


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