Show simple item record

dc.creatorNikolić, Ines
dc.creatorMitsou, Evgenia
dc.creatorDamjanović, Ana
dc.creatorPapadimitriou, Vassiliki
dc.creatorAntić-Stanković, Jelena
dc.creatorStanojević, Boban
dc.creatorXenakis, Aristotelis
dc.creatorSavić, Snežana
dc.date.accessioned2020-02-21T10:45:36Z
dc.date.available2020-02-21T10:45:36Z
dc.date.issued2020
dc.identifier.issn0167-7322
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3528
dc.description.abstractThe objective of this work was to investigate and profoundly characterize low-energy nanoemulsions as multifunctional carriers, with slight reference to dermal administration. An evidence-based approach was offered for deepening the knowledge on their formation via spontaneous emulsification. Curcumin, a compound of natural origin, potentially powerful therapeutic, was chosen as a model API. Due to curcumin's demanding properties (instability, poor solubility, low permeability), its potentials remain unreached. Low-energy nanoemulsions were considered carriers capable of overcoming imposed obstacles. Formulation consisting of Polysorbate 80 and soybean lecithin as stabilizers (9:1, 10%), medium-chain triglycerides as the oil phase (10%) and ultrapure water was selected for curcumin incorporation in 3 different concentrations (1, 2 and 3 mg/mL). Physicochemical stability was demonstrated during 3 months of monitoring (mean droplet size: 111.3-146.8 nm; PDI < 0.2; pH: 4.73-5.73). Curcumin's release from developed vehicles followed Higuchi's kinetics. DPPH (IC50 = 0.1187 mg/ mL) and FRAP (1.19 +/- 0.02 mmol/g) assays confirmed that curcumin acts as a potent antioxidant through different mechanisms, with no alterations after incorporation in the formulation. High biocompatibility in line with antigenotoxic activity of curcumin-loaded formulations (protective and reparative) was estimated through Comet assay. A multidisciplinary approach is needed to fully characterize developed systems, directing them to more concrete application possibilities.en
dc.publisherElsevier B.V.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//
dc.relationDevelopment of Micro- and Nanosystems as Carriers for Drugswith Anti-inflammatory Effect and Methods for Their Characterizationand OI 175011 Biological response modifiers in physiological and path-ological conditions.
dc.rightsrestrictedAccess
dc.sourceJournal of Molecular Liquids
dc.subjectLow-energy nanoemulsions
dc.subjectSpontaneous emulsification
dc.subjectCurcumin
dc.subjectAtomic force microscopy
dc.subjectAntioxidant activity
dc.subject(Anti)genotoxicity
dc.titleCurcumin-loaded low-energy nanoemulsions: Linking EPR spectroscopy-analysed microstructure and antioxidant potential with in vitro evaluated biological activityen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтанојевић, Бобан; Xенакис, Aристотелис; Дамјановић, Aна; Николић, Инес; Митсоу, Евгениа; Пападимитриоу, Вассилики; Савић, Снежана; Aнтић-Станковић, Јелена;
dc.citation.volume301
dc.citation.rankM21~
dc.identifier.wos000445147000033
dc.identifier.doi10.1016/j.molliq.2020.112479
dc.identifier.scopus2-s2.0-85078037387
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record