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Heavy metal and pesticide exposure: A mixture of potential toxicity and carcinogenicity

Authorized Users Only
2020
Authors
Wallace, David R.
Buha-Đorđević, Aleksandra
Article (Published version)
Metadata
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Abstract
There is a growing body of evidence that various pesticides and heavy metals are carcinogenic. If not directly, there is also evidence that shows that these compounds can participate in carcinogenesis in a passive or permissive role, facilitating other compounds from inducing tumor formation. Little evidence is available to aid in understanding the toxicity of metal-pesticide mixtures. In many instances, exposure to subclinical, or subtoxic, levels would be asymptomatic under a single-chemical exposure. But, we do not know how these compounds would act together. A synergistic or potentiating response could be highly possible. By chemically interacting with the environment, as well as each other, metal pesticide mixtures may yield unpredictable toxicity. Because we are not exposed to a single xenobiotic at a time, the importance of studying the toxicity of mixtures has never been more critical.
Keywords:
Arsenic / Cadmium / Carbamate / Mercury / Neonicotinoid / Nickel / Organochlorine / Organophosphate / Pyrethroid
Source:
Current Opinion in Toxicology, 2020, 19, 72-79
Publisher:
  • Elsevier B.V.
Funding / projects:
  • Palinspastika tektonostratigrafskih jedinica između Jadranske i Mezijske ploče (RS-146009)
  • OSU intramural funding [#154333 & #154357]

DOI: 10.1016/j.cotox.2020.01.001

ISSN: 2468-2020

WoS: 000531649300014

Scopus: 2-s2.0-85078877409
[ Google Scholar ]
50
30
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3532
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Wallace, David R.
AU  - Buha-Đorđević, Aleksandra
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3532
AB  - There is a growing body of evidence that various pesticides and heavy metals are carcinogenic. If not directly, there is also evidence that shows that these compounds can participate in carcinogenesis in a passive or permissive role, facilitating other compounds from inducing tumor formation. Little evidence is available to aid in understanding the toxicity of metal-pesticide mixtures. In many instances, exposure to subclinical, or subtoxic, levels would be asymptomatic under a single-chemical exposure. But, we do not know how these compounds would act together. A synergistic or potentiating response could be highly possible. By chemically interacting with the environment, as well as each other, metal pesticide mixtures may yield unpredictable toxicity. Because we are not exposed to a single xenobiotic at a time, the importance of studying the toxicity of mixtures has never been more critical.
PB  - Elsevier B.V.
T2  - Current Opinion in Toxicology
T1  - Heavy metal and pesticide exposure: A mixture of potential toxicity and carcinogenicity
VL  - 19
SP  - 72
EP  - 79
DO  - 10.1016/j.cotox.2020.01.001
ER  - 
@article{
author = "Wallace, David R. and Buha-Đorđević, Aleksandra",
year = "2020",
abstract = "There is a growing body of evidence that various pesticides and heavy metals are carcinogenic. If not directly, there is also evidence that shows that these compounds can participate in carcinogenesis in a passive or permissive role, facilitating other compounds from inducing tumor formation. Little evidence is available to aid in understanding the toxicity of metal-pesticide mixtures. In many instances, exposure to subclinical, or subtoxic, levels would be asymptomatic under a single-chemical exposure. But, we do not know how these compounds would act together. A synergistic or potentiating response could be highly possible. By chemically interacting with the environment, as well as each other, metal pesticide mixtures may yield unpredictable toxicity. Because we are not exposed to a single xenobiotic at a time, the importance of studying the toxicity of mixtures has never been more critical.",
publisher = "Elsevier B.V.",
journal = "Current Opinion in Toxicology",
title = "Heavy metal and pesticide exposure: A mixture of potential toxicity and carcinogenicity",
volume = "19",
pages = "72-79",
doi = "10.1016/j.cotox.2020.01.001"
}
Wallace, D. R.,& Buha-Đorđević, A.. (2020). Heavy metal and pesticide exposure: A mixture of potential toxicity and carcinogenicity. in Current Opinion in Toxicology
Elsevier B.V.., 19, 72-79.
https://doi.org/10.1016/j.cotox.2020.01.001
Wallace DR, Buha-Đorđević A. Heavy metal and pesticide exposure: A mixture of potential toxicity and carcinogenicity. in Current Opinion in Toxicology. 2020;19:72-79.
doi:10.1016/j.cotox.2020.01.001 .
Wallace, David R., Buha-Đorđević, Aleksandra, "Heavy metal and pesticide exposure: A mixture of potential toxicity and carcinogenicity" in Current Opinion in Toxicology, 19 (2020):72-79,
https://doi.org/10.1016/j.cotox.2020.01.001 . .

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