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dc.creatorKrivokuća, Marija
dc.creatorNiketić, Marjan
dc.creatorMilenković, Marina
dc.creatorGolić, Nataša
dc.creatorMasia, Carla
dc.creatorScaltrito, Maria Maddalena
dc.creatorSisto, Franceska
dc.creatorKundaković, Tatjana
dc.date.accessioned2020-02-28T09:48:40Z
dc.date.available2020-02-28T09:48:40Z
dc.date.issued2015
dc.identifier.issn1934-578X
dc.identifier.uri[http://farfar.pharmacy.bg.ac.rs/handle/123456789/3537]
dc.description.abstractThe present study evaluated the anti-Helicobacter pylori activity of Alchemilla glabra Neygenf. (A. sect. Alchemilla), A. monticola Opiz (A. sect. Plicatae S.E. Fröhner), A. fissa Günther & Schummel (A. sect. Calycinae (Buser) Buser) and A. viridiflora Rothm. (A. sect. Calycinae), and identified ellagic acid and quercetin-3-O-β-D-glucoside. Anti-H. pylori activity was tested against ten clinical isolates and one reference strain (ATCC 43504). The methanol extracts were more active than the dichloromethane and cyclohexane extracts. The ranges of concentrations were between 4 μg/mL for methanol extracts of A. viridiflora, A. glabra and A. monticola, and 256 μg/mL for cyclohexane extracts of A. viridiflora, A. glabra and A. fissa. The best overall activity was obtained with A. monticola extracts. No significant difference was found in the ellagic acid contents of the methanol extracts of the tested Alchemilla species (0.2-0.3 mg/mL), and anti-H. pylori activity was similar (4 -32 μg/mL). Ellagic acid exhibited strong activity at very low concentrations (0.125-0.5 μg/mL), while the second identified compound, quercetin-3-O-β-D-glucoside, was also very active in concentration of 2-16 μg/mL.sr
dc.language.isoensr
dc.publisherNatural Products Inc, Westervillesr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173021/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34012/RS//sr
dc.rightsopenAccesssr
dc.sourceNatural Product Communicationsr
dc.subjectAlchemilla sp., Ellagic acid, Helicobacter pylori, Quercetin-3-O-β-D-glucoside.sr
dc.titleAnti-Helicobacter pylori Activity of Four Alchemilla Species (Rosaceae)sr
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractНикетић, Марјан; Кривокуца, Марија; Голић, Наташа; Масиа, Царла; Сцалтрито, Мариа Маддалена; Кундаковић, Татјана; Миленковић, Марина; Систо, Францеска;
dc.citation.volume10
dc.citation.rankM23
dc.description.otherThis is peer-reviedversion ofg the folloving article: (1) Krivokuća, M.; Niketić, M.; Milenković, M.; Golić, N.; Masia, C.; Scaltrito, M. M.; Sisto, F.; Kundaković, T. Anti-Helicobacter Pylori Activity of Four Alchemilla Species (Rosaceae). Nat. Pro. Comm. 2015, 10 (8), 1369–1371.
dc.identifier.wos000359095800014
dc.identifier.scopus2-s2.0-84945989702
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/7406/PROOF1.pdf
dc.type.versionacceptedVersionsr
dc.type.versionpublishedVersion


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