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Hydrophilic excipients in digital light processing (DLP) printing of sustained release tablets: Impact on internal structure and drug dissolution rate

Authorized Users Only
2019
Authors
Krkobabić, Mirjana
Medarević, Đorđe
Cvijić, Sandra
Grujić, Branka
Ibrić, Svetlana
Article (Published version)
Metadata
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Abstract
Three-dimensional (3D) printing enables the production of different objects adjusted for the specific application, which has particular importance of providing personalized therapy, whereby the challenge is to apply pharmaceutical materials into 3D printing technology. In this study, effect of poly(ethylene glycol) 400 (PEG 400), sodium chloride (NaCl), and mannitol, as hydrophilic excipients, was investigated in order to overcome very slow and incomplete drug release from tablets (printlets) fabricated by photopolymerization using digital light processing (DLP) technology. Paracetamol (acetaminophen) was used as a model drug, while polyethylene glycol diacrylate (PEGDA) was used as a photopolymer and diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide as a photoinitiator in photoreactive mixtures. Most of printlet formulations exhibit sustained release over 8 h, wherein drug release kinetics is the best described with Korsmeyer-Peppas kinetics. Variation in the content of photopolymer a...nd excipients had an influence on the dissolution rate, mechanical characteristics, and internal structure of the investigated samples. The addition of hydrophilic polymers increased drug release rate, while PEGDA had the greatest influence on the tensile strength of printlets. The results indicate the possibility of implementation of traditional excipients into different formulations for photopolymerization based 3D printing for the production of small batches of tablets with tailored drug release.

Keywords:
Digital Light Processing (DLP) / Photopolymerization / Sustained release / Three-dimensional (3D) printing
Source:
International Journal of Pharmaceutics, 2019, 572
Publisher:
  • Elsevier
Funding / projects:
  • Advanced technologies for controlled release from solid drug delivery systems (RS-34007)

DOI: 10.1016/j.ijpharm.2019.118790

ISSN: 0378-5173

WoS: 000500308000048

Scopus: 2-s2.0-85075486961
[ Google Scholar ]
35
26
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3540
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Krkobabić, Mirjana
AU  - Medarević, Đorđe
AU  - Cvijić, Sandra
AU  - Grujić, Branka
AU  - Ibrić, Svetlana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3540
AB  - Three-dimensional (3D) printing enables the production of different objects adjusted for the specific application, which has particular importance of providing personalized therapy, whereby the challenge is to apply pharmaceutical materials into 3D printing technology. In this study, effect of poly(ethylene glycol) 400 (PEG 400), sodium chloride (NaCl), and mannitol, as hydrophilic excipients, was investigated in order to overcome very slow and incomplete drug release from tablets (printlets) fabricated by photopolymerization using digital light processing (DLP) technology. Paracetamol (acetaminophen) was used as a model drug, while polyethylene glycol diacrylate (PEGDA) was used as a photopolymer and diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide as a photoinitiator in photoreactive mixtures. Most of printlet formulations exhibit sustained release over 8 h, wherein drug release kinetics is the best described with Korsmeyer-Peppas kinetics. Variation in the content of photopolymer and excipients had an influence on the dissolution rate, mechanical characteristics, and internal structure of the investigated samples. The addition of hydrophilic polymers increased drug release rate, while PEGDA had the greatest influence on the tensile strength of printlets. The results indicate the possibility of implementation of traditional excipients into different formulations for photopolymerization based 3D printing for the production of small batches of tablets with tailored drug release.
PB  - Elsevier
T2  - International Journal of Pharmaceutics
T1  - Hydrophilic excipients in digital light processing (DLP) printing of sustained release tablets: Impact on internal structure and drug dissolution rate
VL  - 572
DO  - 10.1016/j.ijpharm.2019.118790
ER  - 
@article{
author = "Krkobabić, Mirjana and Medarević, Đorđe and Cvijić, Sandra and Grujić, Branka and Ibrić, Svetlana",
year = "2019",
abstract = "Three-dimensional (3D) printing enables the production of different objects adjusted for the specific application, which has particular importance of providing personalized therapy, whereby the challenge is to apply pharmaceutical materials into 3D printing technology. In this study, effect of poly(ethylene glycol) 400 (PEG 400), sodium chloride (NaCl), and mannitol, as hydrophilic excipients, was investigated in order to overcome very slow and incomplete drug release from tablets (printlets) fabricated by photopolymerization using digital light processing (DLP) technology. Paracetamol (acetaminophen) was used as a model drug, while polyethylene glycol diacrylate (PEGDA) was used as a photopolymer and diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide as a photoinitiator in photoreactive mixtures. Most of printlet formulations exhibit sustained release over 8 h, wherein drug release kinetics is the best described with Korsmeyer-Peppas kinetics. Variation in the content of photopolymer and excipients had an influence on the dissolution rate, mechanical characteristics, and internal structure of the investigated samples. The addition of hydrophilic polymers increased drug release rate, while PEGDA had the greatest influence on the tensile strength of printlets. The results indicate the possibility of implementation of traditional excipients into different formulations for photopolymerization based 3D printing for the production of small batches of tablets with tailored drug release.",
publisher = "Elsevier",
journal = "International Journal of Pharmaceutics",
title = "Hydrophilic excipients in digital light processing (DLP) printing of sustained release tablets: Impact on internal structure and drug dissolution rate",
volume = "572",
doi = "10.1016/j.ijpharm.2019.118790"
}
Krkobabić, M., Medarević, Đ., Cvijić, S., Grujić, B.,& Ibrić, S.. (2019). Hydrophilic excipients in digital light processing (DLP) printing of sustained release tablets: Impact on internal structure and drug dissolution rate. in International Journal of Pharmaceutics
Elsevier., 572.
https://doi.org/10.1016/j.ijpharm.2019.118790
Krkobabić M, Medarević Đ, Cvijić S, Grujić B, Ibrić S. Hydrophilic excipients in digital light processing (DLP) printing of sustained release tablets: Impact on internal structure and drug dissolution rate. in International Journal of Pharmaceutics. 2019;572.
doi:10.1016/j.ijpharm.2019.118790 .
Krkobabić, Mirjana, Medarević, Đorđe, Cvijić, Sandra, Grujić, Branka, Ibrić, Svetlana, "Hydrophilic excipients in digital light processing (DLP) printing of sustained release tablets: Impact on internal structure and drug dissolution rate" in International Journal of Pharmaceutics, 572 (2019),
https://doi.org/10.1016/j.ijpharm.2019.118790 . .

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