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dc.creatorAaseth, Jan
dc.creatorBuha, Aleksandra
dc.creatorWallace, David R.
dc.creatorBjørklund, Geir
dc.date.accessioned2020-03-03T12:13:14Z
dc.date.available2020-03-03T12:13:14Z
dc.date.issued2020
dc.identifier.issn1661-7827
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3544
dc.description.abstractTauopathies are a disease group characterized by either pathological accumulation or release of fragments of hyperphosphorylated tau proteins originating from the central nervous system. The tau hypotheses of Parkinson’s and Alzheimer’s diseases contain a clinically diverse spectrum of tauopathies. Studies of case records of various tauopathies may reveal clinical phenotype characteristics of the disease. In addition, improved understanding of different tauopathies would disclose environmental factors, such as xenobiotics and trace metals, that can precipitate or modify the progression of the disorder. Important for diagnostics and monitoring of these disorders is a further development of adequate biomarkers, including refined neuroimaging, or proteomics. Our goal is to provide an in-depth review of the current literature regarding the pathophysiological roles of tau proteins and the pathogenic factors leading to various tauopathies, with the perspective of future advances in potential therapeutic strategies.en
dc.publisherMDPI
dc.relationInnlandet Hospital Trust, Norway, and by the Oklahoma State University Center for Health Sciences Seed/Pilot Grant Program, grant number 154357.
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceInternational Journal of Environmental Research and Public Health
dc.subjectMetals
dc.subjectPathogenesis
dc.subjectTauopathies
dc.subjectXenobiotics
dc.titleXenobiotics, trace metals and genetics in the pathogenesis of tauopathiesen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractБјøрклунд, Геир; Aасетх, Јан; Буха, Aлександра; Wаллаце, Давид Р.;
dc.citation.volume17
dc.citation.issue4
dc.citation.rankM21
dc.identifier.wos000522388500145
dc.identifier.doi10.3390/ijerph17041269
dc.identifier.scopus2-s2.0-85079640442
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs/bitstream/id/7589/bitstream_7589.pdf
dc.type.versionpublishedVersion


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