Usnic acid is one of the most investigated lichen secondary metabolites, with several proven biological properties with potential medical relevance. However, its unfavorable physico-chemical properties, as well as observed hepatotoxicity, have discouraged wide-range utilization of usnic acid as a promising therapeutic agent. In accordance with the growing research interest in the development of nanotechnology, especially in the arena of preparations based on natural sources of medicinal compounds, usnic acid incorporated into nano-and microsized colloidal carriers has been a subject of a large number of publications. Therefore, this review discusses the overall results of the studies dealing with usnic acid encapsulated into lipid-based, polymeric and nonorganic micro-and/or nanocarriers, as potential drug delivery systems for this natural compound, in an attempt to introduce its usage as a potential antitumor, antimicrobial, wound-healing, antioxidative and anti-inflammatory drug.
TY - JOUR
AU - Žugić, Ana
AU - Tadić, Vanja
AU - Savić, Snežana
PY - 2020
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/3545
AB - Usnic acid is one of the most investigated lichen secondary metabolites, with several proven biological properties with potential medical relevance. However, its unfavorable physico-chemical properties, as well as observed hepatotoxicity, have discouraged wide-range utilization of usnic acid as a promising therapeutic agent. In accordance with the growing research interest in the development of nanotechnology, especially in the arena of preparations based on natural sources of medicinal compounds, usnic acid incorporated into nano-and microsized colloidal carriers has been a subject of a large number of publications. Therefore, this review discusses the overall results of the studies dealing with usnic acid encapsulated into lipid-based, polymeric and nonorganic micro-and/or nanocarriers, as potential drug delivery systems for this natural compound, in an attempt to introduce its usage as a potential antitumor, antimicrobial, wound-healing, antioxidative and anti-inflammatory drug.
PB - MDPI
T2 - Pharmaceutics
T1 - Nano-and microcarriers as drug delivery systems for usnic acid: Review of literature
VL - 12
IS - 2
DO - 10.3390/pharmaceutics12020156
ER -
@article{
author = "Žugić, Ana and Tadić, Vanja and Savić, Snežana",
year = "2020",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/3545",
abstract = "Usnic acid is one of the most investigated lichen secondary metabolites, with several proven biological properties with potential medical relevance. However, its unfavorable physico-chemical properties, as well as observed hepatotoxicity, have discouraged wide-range utilization of usnic acid as a promising therapeutic agent. In accordance with the growing research interest in the development of nanotechnology, especially in the arena of preparations based on natural sources of medicinal compounds, usnic acid incorporated into nano-and microsized colloidal carriers has been a subject of a large number of publications. Therefore, this review discusses the overall results of the studies dealing with usnic acid encapsulated into lipid-based, polymeric and nonorganic micro-and/or nanocarriers, as potential drug delivery systems for this natural compound, in an attempt to introduce its usage as a potential antitumor, antimicrobial, wound-healing, antioxidative and anti-inflammatory drug.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Nano-and microcarriers as drug delivery systems for usnic acid: Review of literature",
volume = "12",
number = "2",
doi = "10.3390/pharmaceutics12020156"
}
Žugić, A., Tadić, V.,& Savić, S. (2020). Nano-and microcarriers as drug delivery systems for usnic acid: Review of literature.
Pharmaceutics
MDPI., 12(2).
https://doi.org/10.3390/pharmaceutics12020156
Žugić A, Tadić V, Savić S. Nano-and microcarriers as drug delivery systems for usnic acid: Review of literature. Pharmaceutics. 2020;12(2)
Žugić Ana, Tadić Vanja, Savić Snežana, "Nano-and microcarriers as drug delivery systems for usnic acid: Review of literature" Pharmaceutics, 12, no. 2 (2020),
https://doi.org/10.3390/pharmaceutics12020156 .
