Nano-and microcarriers as drug delivery systems for usnic acid: Review of literature
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Usnic acid is one of the most investigated lichen secondary metabolites, with several proven biological properties with potential medical relevance. However, its unfavorable physico-chemical properties, as well as observed hepatotoxicity, have discouraged wide-range utilization of usnic acid as a promising therapeutic agent. In accordance with the growing research interest in the development of nanotechnology, especially in the arena of preparations based on natural sources of medicinal compounds, usnic acid incorporated into nano-and microsized colloidal carriers has been a subject of a large number of publications. Therefore, this review discusses the overall results of the studies dealing with usnic acid encapsulated into lipid-based, polymeric and nonorganic micro-and/or nanocarriers, as potential drug delivery systems for this natural compound, in an attempt to introduce its usage as a potential antitumor, antimicrobial, wound-healing, antioxidative and anti-inflammatory drug.
Keywords:
Delivery systems / Microcarriers / Nanocarriers / Natural products / Usnic acidSource:
Pharmaceutics, 2020, 12, 2Publisher:
- MDPI
Funding / projects:
- Functional physiologically active plant materials with additional values for application in pharmaceutical and food industry (RS-45017)
- Project No. E!12689 in Eureka Programs
DOI: 10.3390/pharmaceutics12020156
ISSN: 1999-4923
WoS: 000519268500012
Scopus: 2-s2.0-85079679870
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PharmacyTY - JOUR AU - Žugić, Ana AU - Tadić, Vanja AU - Savić, Snežana PY - 2020 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3545 AB - Usnic acid is one of the most investigated lichen secondary metabolites, with several proven biological properties with potential medical relevance. However, its unfavorable physico-chemical properties, as well as observed hepatotoxicity, have discouraged wide-range utilization of usnic acid as a promising therapeutic agent. In accordance with the growing research interest in the development of nanotechnology, especially in the arena of preparations based on natural sources of medicinal compounds, usnic acid incorporated into nano-and microsized colloidal carriers has been a subject of a large number of publications. Therefore, this review discusses the overall results of the studies dealing with usnic acid encapsulated into lipid-based, polymeric and nonorganic micro-and/or nanocarriers, as potential drug delivery systems for this natural compound, in an attempt to introduce its usage as a potential antitumor, antimicrobial, wound-healing, antioxidative and anti-inflammatory drug. PB - MDPI T2 - Pharmaceutics T1 - Nano-and microcarriers as drug delivery systems for usnic acid: Review of literature VL - 12 IS - 2 DO - 10.3390/pharmaceutics12020156 ER -
@article{ author = "Žugić, Ana and Tadić, Vanja and Savić, Snežana", year = "2020", abstract = "Usnic acid is one of the most investigated lichen secondary metabolites, with several proven biological properties with potential medical relevance. However, its unfavorable physico-chemical properties, as well as observed hepatotoxicity, have discouraged wide-range utilization of usnic acid as a promising therapeutic agent. In accordance with the growing research interest in the development of nanotechnology, especially in the arena of preparations based on natural sources of medicinal compounds, usnic acid incorporated into nano-and microsized colloidal carriers has been a subject of a large number of publications. Therefore, this review discusses the overall results of the studies dealing with usnic acid encapsulated into lipid-based, polymeric and nonorganic micro-and/or nanocarriers, as potential drug delivery systems for this natural compound, in an attempt to introduce its usage as a potential antitumor, antimicrobial, wound-healing, antioxidative and anti-inflammatory drug.", publisher = "MDPI", journal = "Pharmaceutics", title = "Nano-and microcarriers as drug delivery systems for usnic acid: Review of literature", volume = "12", number = "2", doi = "10.3390/pharmaceutics12020156" }
Žugić, A., Tadić, V.,& Savić, S.. (2020). Nano-and microcarriers as drug delivery systems for usnic acid: Review of literature. in Pharmaceutics MDPI., 12(2). https://doi.org/10.3390/pharmaceutics12020156
Žugić A, Tadić V, Savić S. Nano-and microcarriers as drug delivery systems for usnic acid: Review of literature. in Pharmaceutics. 2020;12(2). doi:10.3390/pharmaceutics12020156 .
Žugić, Ana, Tadić, Vanja, Savić, Snežana, "Nano-and microcarriers as drug delivery systems for usnic acid: Review of literature" in Pharmaceutics, 12, no. 2 (2020), https://doi.org/10.3390/pharmaceutics12020156 . .