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Eslicarbazepine acetate interacts in a beneficial manner with standard and alternative analgesics to reduce trigeminal nociception

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2020
Authors
Pecikoza, Uroš
Tomić, Maja
Micov, Ana
Vuković, Milja
Stepanović-Petrović, Radica
Article (Accepted Version)
,
Springer-Verlag
Metadata
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Abstract
Rationale: Acute pain states in the trigeminal region (headaches, dental pain) fall into the most prevalent painful conditions. Standard analgesics (paracetamol/NSAIDs) represent the cornerstone of their treatment, whereas triptans are primarily used in migraine attacks. Due to limited efficacy and/or side effects of current treatments, identifying favorable combinations of available drugs is justified. Objectives: Eslicarbazepine acetate (ESL) is a novel antiepileptic drug whose effectiveness against trigeminal pain was recently demonstrated. Here, we examined the interactions between ESL and several standard/alternative analgesics (paracetamol, propyphenazone, naproxen, zolmitriptan, and metoclopramide) in a model of trigeminal pain. Methods: The antinociceptive effects of orally administered ESL, standard/alternative analgesics, and two-drug ESL-analgesic combinations were examined in the orofacial formalin test in mice. The type of interaction between drugs was determined by isob...olographic analysis. Results: ESL, analgesics, and two-drug ESL-analgesic combinations significantly and dose-dependently reduced nociceptive behaviour in the second, inflammatory phase of the test. Isobolographic analysis revealed that ESL interacted additively with paracetamol/propyphenazone/zolmitriptan and synergistically with naproxen/metoclopramide (with about a 4-fold and 3-fold reduction of doses in the ESL-naproxen and ESL-metoclopramide combination, respectively). Conclusions: ESL interacted in a beneficial manner with several analgesics that are used for trigeminal pain treatment, producing synergistic interactions with naproxen/metoclopramide and additive interactions with paracetamol/propyphenazone/zolmitriptan. Our results suggest that combining ESL with analgesics could theoretically enable the use of lower doses of individual drugs for achieving pain relief.

Keywords:
Eslicarbazepine acetate / Isobolographic analysis / Metoclopramide / Non-opioid analgesics / Orofacial nociception / Triptans
Source:
Psychopharmacology, 2020
Publisher:
  • Springer-Verlag
Projects:
  • Examination of mechanisms of action, toxicity and interactions of adjuvant analgesics (RS-175045)
Note:
  • This is peer-reviewd wersion of the foloving article: Pecikoza, U.; Tomić, M.; Micov, A.; Vuković, M.; Stepanović-Petrović, R. Eslicarbazepine Acetate Interacts in a Beneficial Manner with Standard and Alternative Analgesics to Reduce Trigeminal Nociception. Psychopharmacology 2020. https://doi.org/10.1007/s00213-020-05470-7.

DOI: 10.1007/s00213-020-05470-7

ISSN: 0033-3158

WoS: 000515840900001

Scopus: 2-s2.0-85079176511
[ Google Scholar ]
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3546
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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