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dc.creatorPecikoza, Uroš
dc.creatorTomić, Maja
dc.creatorMicov, Ana
dc.creatorVuković, Milja
dc.creatorStepanović-Petrović, Radica
dc.date.accessioned2020-03-04T07:50:22Z
dc.date.available2020-03-04T07:50:22Z
dc.date.issued2020
dc.identifier.issn0033-3158
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3546
dc.description.abstractRationale: Acute pain states in the trigeminal region (headaches, dental pain) fall into the most prevalent painful conditions. Standard analgesics (paracetamol/NSAIDs) represent the cornerstone of their treatment, whereas triptans are primarily used in migraine attacks. Due to limited efficacy and/or side effects of current treatments, identifying favorable combinations of available drugs is justified. Objectives: Eslicarbazepine acetate (ESL) is a novel antiepileptic drug whose effectiveness against trigeminal pain was recently demonstrated. Here, we examined the interactions between ESL and several standard/alternative analgesics (paracetamol, propyphenazone, naproxen, zolmitriptan, and metoclopramide) in a model of trigeminal pain. Methods: The antinociceptive effects of orally administered ESL, standard/alternative analgesics, and two-drug ESL-analgesic combinations were examined in the orofacial formalin test in mice. The type of interaction between drugs was determined by isobolographic analysis. Results: ESL, analgesics, and two-drug ESL-analgesic combinations significantly and dose-dependently reduced nociceptive behaviour in the second, inflammatory phase of the test. Isobolographic analysis revealed that ESL interacted additively with paracetamol/propyphenazone/zolmitriptan and synergistically with naproxen/metoclopramide (with about a 4-fold and 3-fold reduction of doses in the ESL-naproxen and ESL-metoclopramide combination, respectively). Conclusions: ESL interacted in a beneficial manner with several analgesics that are used for trigeminal pain treatment, producing synergistic interactions with naproxen/metoclopramide and additive interactions with paracetamol/propyphenazone/zolmitriptan. Our results suggest that combining ESL with analgesics could theoretically enable the use of lower doses of individual drugs for achieving pain relief.en
dc.language.isoensr
dc.publisherSpringer-Verlagsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175045/RS//sr
dc.rightsembargoedAccesssr
dc.sourcePsychopharmacologysr
dc.subjectEslicarbazepine acetatesr
dc.subjectIsobolographic analysissr
dc.subjectMetoclopramidesr
dc.subjectNon-opioid analgesicssr
dc.subjectOrofacial nociceptionsr
dc.subjectTriptanssr
dc.titleEslicarbazepine acetate interacts in a beneficial manner with standard and alternative analgesics to reduce trigeminal nociceptionen
dc.typearticlesr
dc.rights.licenseBY-NC-NDsr
dcterms.abstractТомић, Маја; Степановић-Петровић, Радица; Вуковић, Миља; Пецикоза, Урош; Мицов, Aна;
dc.rights.holderSpringer-Verlagsr
dc.citation.rankM21
dc.description.otherThis is peer-reviewd wersion of the foloving article: Pecikoza, U.; Tomić, M.; Micov, A.; Vuković, M.; Stepanović-Petrović, R. Eslicarbazepine Acetate Interacts in a Beneficial Manner with Standard and Alternative Analgesics to Reduce Trigeminal Nociception. Psychopharmacology 2020. [https://doi.org/10.1007/s00213-020-05470-7.]
dc.identifier.wos000515840900001
dc.identifier.doi10.1007/s00213-020-05470-7
dc.identifier.scopus2-s2.0-85079176511
dc.type.versionacceptedVersionsr
dc.type.versionpublishedVersion


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