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dc.creatorPecikoza, Uroš
dc.creatorTomić, Maja
dc.creatorMicov, Ana
dc.creatorVuković, Milja
dc.creatorStepanović-Petrović, Radica
dc.date.accessioned2020-03-04T08:41:23Z
dc.date.available2020-03-04T08:41:23Z
dc.date.issued2020
dc.identifier.issn0033-3158
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3547
dc.description.abstractRationale: Acute pain states in the trigeminal region (headaches, dental pain) fall into the most prevalent painful conditions. Standard analgesics (paracetamol/NSAIDs) represent the cornerstone of their treatment, whereas triptans are primarily used in migraine attacks. Due to limited efficacy and/or side effects of current treatments, identifying favorable combinations of available drugs is justified. Objectives: Eslicarbazepine acetate (ESL) is a novel antiepileptic drug whose effectiveness against trigeminal pain was recently demonstrated. Here, we examined the interactions between ESL and several standard/alternative analgesics (paracetamol, propyphenazone, naproxen, zolmitriptan, and metoclopramide) in a model of trigeminal pain. Methods: The antinociceptive effects of orally administered ESL, standard/alternative analgesics, and two-drug ESL-analgesic combinations were examined in the orofacial formalin test in mice. The type of interaction between drugs was determined by isobolographic analysis. Results: ESL, analgesics, and two-drug ESL-analgesic combinations significantly and dose-dependently reduced nociceptive behaviour in the second, inflammatory phase of the test. Isobolographic analysis revealed that ESL interacted additively with paracetamol/propyphenazone/zolmitriptan and synergistically with naproxen/metoclopramide (with about a 4-fold and 3-fold reduction of doses in the ESL-naproxen and ESL-metoclopramide combination, respectively). Conclusions: ESL interacted in a beneficial manner with several analgesics that are used for trigeminal pain treatment, producing synergistic interactions with naproxen/metoclopramide and additive interactions with paracetamol/propyphenazone/zolmitriptan. Our results suggest that combining ESL with analgesics could theoretically enable the use of lower doses of individual drugs for achieving pain relief.en
dc.publisherSpringer Nature
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175045/RS//
dc.rightsrestrictedAccess
dc.sourcePsychopharmacology
dc.subjectEslicarbazepine acetate
dc.subjectIsobolographic analysis
dc.subjectMetoclopramide
dc.subjectNon-opioid analgesics
dc.subjectOrofacial nociception
dc.subjectTriptans
dc.titleEslicarbazepine acetate interacts in a beneficial manner with standard and alternative analgesics to reduce trigeminal nociceptionen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВуковић, Миља; Пецикоза, Урош; Томић, Маја; Мицов, Aна; Степановић-Петровић, Радица;
dc.citation.volume237
dc.citation.issue5
dc.citation.spage1435
dc.citation.epage1446
dc.citation.rankM21~
dc.description.otherPeer-reviewd manuscript: [http://farfar.pharmacy.bg.ac.rs/handle/123456789/3546]
dc.identifier.wos000515840900001
dc.identifier.doi10.1007/s00213-020-05470-7
dc.identifier.scopus2-s2.0-85079176511
dc.type.versionpublishedVersion


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