The X Files: “The Mystery of X Chromosome Instability in Alzheimer’s Disease”
Аутори
Bajić, Vladan. P.Essack, Magbubah
Živković, Lada
Stewart, Alan
Zafirović, Sonja
Bajić, Vladimir B.
Gojobori, Takashi
Isenović, Esma
Spremo-Potparević, Biljana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Alzheimer’s disease (AD) is a neurodegenerative disease that affects millions of individuals worldwide and can occur relatively early or later in life. It is well known that genetic components, such as the amyloid precursor protein gene on chromosome 21, are fundamental in early-onset AD (EOAD). To date, however, only the apolipoprotein E4 (ApoE4) gene has been proved to be a genetic risk factor for late-onset AD (LOAD). In recent years, despite the hypothesis that many additional unidentified genes are likely to play a role in AD development, it is surprising that additional gene polymorphisms associated with LOAD have failed to come to light. In this review, we examine the role of X chromosome epigenetics and, based upon GWAS studies, the PCDHX11 gene. Furthermore, we explore other genetic risk factors of AD that involve X-chromosome epigenetics.
Кључне речи:
Alzheimer’s disease / centromere instability / protocadherin 11 / sex chromosome dosage / X chromosomeИзвор:
Frontiers in Genetics, 2020, 10Издавач:
- Frontiers Media S.A.
Финансирање / пројекти:
- Хормонска регулација експресије и активности азот оксид синтазе и натријум-калијумове пумпе у експерименталним моделима инсулинске резистенције, дијабетеса и кардиоваскуларних поремећаја (RS-173033)
- Аберације ћелијског циклуса и утицај оксидативног стреса на неуродегенеративне процесе и малигну трансформацију ћелије (RS-173034)
- KAUST grant OSR#4129 (to EI and VBB), which also supported SZ and VPB. VBB has been supported by the KAUST Base Research Fund (BAS/1/1606-01-01), while VBB and ME have been supported by KAUST Office of Sponsored Research (OSR) grant no. FCC/1/1976-17-01. TG has been supported by the King Abdullah University of Science and Technology (KAUST) Base Research Fund (BAS/1/1059-01-01).
DOI: 10.3389/fgene.2019.01368
ISSN: 1664-8021
WoS: 000514292900001
Scopus: 2-s2.0-85079496526
Институција/група
PharmacyTY - JOUR AU - Bajić, Vladan. P. AU - Essack, Magbubah AU - Živković, Lada AU - Stewart, Alan AU - Zafirović, Sonja AU - Bajić, Vladimir B. AU - Gojobori, Takashi AU - Isenović, Esma AU - Spremo-Potparević, Biljana PY - 2020 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3554 AB - Alzheimer’s disease (AD) is a neurodegenerative disease that affects millions of individuals worldwide and can occur relatively early or later in life. It is well known that genetic components, such as the amyloid precursor protein gene on chromosome 21, are fundamental in early-onset AD (EOAD). To date, however, only the apolipoprotein E4 (ApoE4) gene has been proved to be a genetic risk factor for late-onset AD (LOAD). In recent years, despite the hypothesis that many additional unidentified genes are likely to play a role in AD development, it is surprising that additional gene polymorphisms associated with LOAD have failed to come to light. In this review, we examine the role of X chromosome epigenetics and, based upon GWAS studies, the PCDHX11 gene. Furthermore, we explore other genetic risk factors of AD that involve X-chromosome epigenetics. PB - Frontiers Media S.A. T2 - Frontiers in Genetics T1 - The X Files: “The Mystery of X Chromosome Instability in Alzheimer’s Disease” VL - 10 DO - 10.3389/fgene.2019.01368 ER -
@article{ author = "Bajić, Vladan. P. and Essack, Magbubah and Živković, Lada and Stewart, Alan and Zafirović, Sonja and Bajić, Vladimir B. and Gojobori, Takashi and Isenović, Esma and Spremo-Potparević, Biljana", year = "2020", abstract = "Alzheimer’s disease (AD) is a neurodegenerative disease that affects millions of individuals worldwide and can occur relatively early or later in life. It is well known that genetic components, such as the amyloid precursor protein gene on chromosome 21, are fundamental in early-onset AD (EOAD). To date, however, only the apolipoprotein E4 (ApoE4) gene has been proved to be a genetic risk factor for late-onset AD (LOAD). In recent years, despite the hypothesis that many additional unidentified genes are likely to play a role in AD development, it is surprising that additional gene polymorphisms associated with LOAD have failed to come to light. In this review, we examine the role of X chromosome epigenetics and, based upon GWAS studies, the PCDHX11 gene. Furthermore, we explore other genetic risk factors of AD that involve X-chromosome epigenetics.", publisher = "Frontiers Media S.A.", journal = "Frontiers in Genetics", title = "The X Files: “The Mystery of X Chromosome Instability in Alzheimer’s Disease”", volume = "10", doi = "10.3389/fgene.2019.01368" }
Bajić, Vladan. P., Essack, M., Živković, L., Stewart, A., Zafirović, S., Bajić, V. B., Gojobori, T., Isenović, E.,& Spremo-Potparević, B.. (2020). The X Files: “The Mystery of X Chromosome Instability in Alzheimer’s Disease”. in Frontiers in Genetics Frontiers Media S.A.., 10. https://doi.org/10.3389/fgene.2019.01368
Bajić VP, Essack M, Živković L, Stewart A, Zafirović S, Bajić VB, Gojobori T, Isenović E, Spremo-Potparević B. The X Files: “The Mystery of X Chromosome Instability in Alzheimer’s Disease”. in Frontiers in Genetics. 2020;10. doi:10.3389/fgene.2019.01368 .
Bajić, Vladan. P., Essack, Magbubah, Živković, Lada, Stewart, Alan, Zafirović, Sonja, Bajić, Vladimir B., Gojobori, Takashi, Isenović, Esma, Spremo-Potparević, Biljana, "The X Files: “The Mystery of X Chromosome Instability in Alzheimer’s Disease”" in Frontiers in Genetics, 10 (2020), https://doi.org/10.3389/fgene.2019.01368 . .