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Primena profilaktičkih vakcina kod starih

dc.creatorBufan, Biljana
dc.date.accessioned2020-05-27T10:02:28Z
dc.date.available2020-05-27T10:02:28Z
dc.date.issued2019
dc.identifier.issn0004-1963
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3562
dc.description.abstractExtended lifespan and increasing number of the elderly (>65 years) worldwide carries the challenges for the public health system, as this is the population particularly susceptible to infectious diseases. One way to prevent these diseases is vaccination. In order to improve the quality of life of the elderly, to reduce complications, hospitalizations and mortality, many European countries and the United States recommend the vaccination of the elderly with the influenza vaccine, vaccines against Streptococcus pneumoniae and Varicella-zoster virus (VZV), and booster vaccination against tetanus, pertussis and diphtheria. The reason for the greater susceptibility to infectious diseases, and lower efficacy of vaccines in the elderly, are age-associated changes of the immune system. In most European countries seasonal influenza vaccine is recommended for the individuals over 65 years of age. Its efficacy is lower in the elderly than in adults, so strategies are being developed to overcome these problems (including adjuvants in the formulation, increasing the antigen dose, changing the route of immunization, development of vector-based vaccines). Polysaccharide and conjugated vaccines are available against S. pneumoniae, but data regarding their efficacy are inconsistent. The VZV vaccine is an attenuated, live vaccine and has been shown to be effective in reducing the incidence of herpes zoster and post-herpetic neuralgia. Raising awareness of the importance of vaccination in the elderly and the development of vaccines tailored for this population is of great importance for the preservation of their health. © 2019, Pharmaceutical Association of Serbia.
dc.description.abstractProduženje ljudskog veka i povećanje broja starih (stariji od 65 godina) na svetskom nivou nosi sa sobom izazove za javno-zdravstveni sistem jer se radi o populaciji podložnoj infektivnim bolestima. Vakcinacija je jedan od načina prevencije ovih bolesti. U cilju poboljšanja kvaliteta života, smanjenja komplikacija bolesti, hospitalizacija i mortaliteta starih, mnoge evropske države i Sjedinjene Američke Države, kod starih osoba, preporučuju vakcinaciju protiv gripa, pneumokoka, varičela-zoster virusa (VZV), kao i „booster” vakcinacije protiv tetanusa, pertusisa i difterije. Razlog veće podložnosti infektivnim bolestima i manjoj efikasnosti vakcina kod starih su starenjem uslovljene promene koje pogađaju imunski sistem, a koje utiču na njegovu funkciju. Sezonska vakcina protiv gripa se u većini evropskih zemalja preporučuje starijima od 65 godina. Budući da je njena efikasnost niža kod starih nego kod odraslih osoba, razvijaju se strategije koje bi prevazišle ovaj problem (uključivanje adjuvansa u formulaciju, povećanje doze, promena puta unošenja antigena, razvoj vektorskih vakcina). Protiv pneumokoka su dostupne polisaharidna i konjugovana vakcina, a podaci o njihovoj efikasnosti su nekonzistentni. Vakcina protiv VZVje atenuisana, živa vakcina i pokazala se efikasna u smanjenju incidencije herpes zostera i post-herpetične neuralgije.
dc.publisherBeograd : Savez farmaceutskih udruženja Srbije
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsopenAccess
dc.sourceArhiv za Farmaciju
dc.subjectSeasonal influenza vaccine
dc.subjectThe elderly
dc.subjectVaccine against Streptococcus pneumoniae
dc.subjectVaccine against Varicella zoster virus
dc.subjectstare osobe
dc.subjectsezonska vakcina protiv Virus influenzae
dc.subjectvakcina protiv Streptococcus pneumoniae
dc.subjectvakcina protiv Varicella-zoster virus
dc.titleApplication of prophylactic vaccines in the elderly
dc.titlePrimena profilaktičkih vakcina kod starih
dc.typearticle
dc.rights.licenseBY-SA
dcterms.abstractБуфан, Биљана; Примена профилактичких вакцина код старих;
dc.citation.volume69
dc.citation.issue6
dc.citation.spage469
dc.citation.epage489
dc.citation.rankM52
dc.identifier.doi10.5937/arhfarm1906469B
dc.identifier.scopus2-s2.0-85080958683
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/7641/Application_of_prophylactic_pub_2019.pdf
dc.type.versionpublishedVersion


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