FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Established and advanced adjuvants in vaccines' formulation: Mineral adsorbents, nanoparticulate carriers and microneedle delivery systems

Konvencionalni i napredni adjuvansi u formulacijama vakcina: mineralni adsorbenti, nanočestični nosači i sistemi tipa mikroigala

Thumbnail
2019
Established_and_Advanced_pub_2019.pdf (479.0Kb)
Authors
Krajišnik, Danina
Ilić, Tanja
Nikolić, Ines
Savić, Snežana
Article (Published version)
Metadata
Show full item record
Abstract
In the era of modern vaccinology, limited immunogenicity of the most commonly used antigens has enforced the use of various adjuvants in vaccine formulations to achieve desired immune response. Aluminum-containing adjuvants have been, historically, the most widely used mineral immunostimulants, generally regarded as safe to use in human vaccines. The great academic progress in inorganic (nano)materials synthesis, structure control and functionalization design has led to a growing interest in innovative adjuvants such as clays, mesoporous silica nanoparticles, zinc oxide, iron oxide and iron hydroxide nanoparticles, etc. On the other hand, there has been an intention to use specific nanoparticulated antigen delivery systems, such as nanoemulsions, in order to protect antigens from premature proteolytic degradation and/or to improve antigen immunogenicity by facilitating antigen uptake and processing by antigen presenting cells. Sim...ultaneously, numerous research efforts have been focused on the development of innovative technologies for antigen delivery into the skin (such as microneedles), with the aim to improve vaccine efficacy alongside with enhanced patient adherence, particularly in children population (noninvasive or minimally invasive administration). Therefore, this review deals with each of these approaches in more detail, with the special emphasis on examples of their use in vaccine formulations as well as on the factors influencing their efficacy and safety.

U doba savremene vakcinologije, ograničena imunogenost većine korišćenih antigena podstakla je primenu različitih adjuvanasa u formulacijama vakcina radi postizanja željenog imunskog odgovora. Mineralni adjuvansi na bazi aluminijuma su istorijski najčešće korišćeni imunostimulansi u vakcinama i smatraju se generalno bezbednim za humanu upotrebu. Značajni napredak na polju sinteze, kontrole strukture i funkcionalnog dizajna neorganskih (nano)materijala uslovio je povećano interesovanje za primenom inovativnih adjuvanasa kao što su gline, mezoporozne silika nanočestice, nanočestice cink-oksida, gvožđe oksida i gvožđe hidroksida, i dr. Sa druge strane, uočava se i sve veće interesovanje za primenom specifičnih nanonosača antigena, kao što su nanoemulzije, kako bi se antigeni zaštitili od preuranjene proteolitičke degradacije i/ili poboljšala njihova imunogenost, olakšavanjem preuzimanja i obrade od strane antigen-prezentujućih će...lija. Takođe, brojni istraživački napori tokom poslednjih nekoliko godina usmereni su ka razvoju inovativnih tehnologija za isporuku antigena u kožu (kao što su mikroigle) radi poboljšanja efikasnosti vakcinacije uz istovremeno povećanje adherence pacijenata, posebno u pedijatrijskoj populaciji (neinvazivan ili minimalno invazivan način primene). Otuda, u ovom preglednom radu dat je detaljan pregled karakteristika svakog od navedenih pristupa za poboljšanje efikasnosti vakcina, sa posebnim osvrtom na primere njihove primene u formulacijama vakcina i faktore koji određuju efikasnost i bezbednost.

Keywords:
Adjuvants / Microneedles / Mineral adsorbents / Nanoemulsions / Vaccine formulation / formulacija vakcina / adjuvansi / mineralni adsorbenti / anoemulzije / mikroigle
Source:
Arhiv za farmaciju, 2019, 69, 6, 420-451
Publisher:
  • Beograd : Savez farmaceutskih udruženja Srbije
Funding / projects:
  • Development of micro- and nanosystems as carriers for drugs with anti-inflammatory effect and methods for their characterization (RS-34031)

DOI: 10.5937/arhfarm1906420K

ISSN: 0004-1963

Scopus: 2-s2.0-85080864251
[ Google Scholar ]
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3567
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Krajišnik, Danina
AU  - Ilić, Tanja
AU  - Nikolić, Ines
AU  - Savić, Snežana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3567
AB  - In the era of modern vaccinology, limited immunogenicity of the most commonly used antigens has enforced the use of various adjuvants in vaccine formulations to achieve desired immune  response.  Aluminum-containing  adjuvants  have  been,  historically,  the  most  widely used mineral immunostimulants, generally regarded as safe to use in human vaccines. The great academic   progress   in   inorganic   (nano)materials   synthesis,   structure   control   and functionalization design has  led  to  a  growing  interest  in innovative  adjuvants  such  as  clays, mesoporous silica nanoparticles, zinc oxide, iron oxide and iron hydroxide nanoparticles, etc. On the other hand, there has been an intention to use specific nanoparticulated antigen delivery systems,  such  as  nanoemulsions,  in  order  to  protect  antigens  from  premature  proteolytic degradation  and/or  to  improve  antigen  immunogenicity  by  facilitating  antigen  uptake  and processing by antigen presenting cells. Simultaneously, numerous research efforts have been focused on the development of innovative technologies for antigen delivery into the skin (such as microneedles), with the aim to improve vaccine efficacy alongside with enhanced patient adherence,  particularly  in  children  population  (noninvasive  or minimally  invasive administration). Therefore, this review deals with each of these approaches in more detail, with the special emphasis on examples of their use in vaccine formulations as well as on the factors influencing their efficacy and safety.
AB  - U  doba  savremene  vakcinologije,  ograničena  imunogenost  većine  korišćenih  antigena podstakla  je  primenu  različitih  adjuvanasa  u  formulacijama  vakcina  radi  postizanja  željenog imunskog odgovora. Mineralni adjuvansi na bazi aluminijuma su istorijski najčešće korišćeni imunostimulansi u vakcinama i smatraju se generalno bezbednim za humanu upotrebu. Značajni napredak  na  polju  sinteze,  kontrole  strukture  i  funkcionalnog  dizajna  neorganskih (nano)materijala uslovio je povećano interesovanje za primenom inovativnih adjuvanasa kao što su  gline,  mezoporozne  silika  nanočestice,  nanočestice  cink-oksida,  gvožđe  oksida  i  gvožđe hidroksida, i dr. Sa druge strane, uočava se i sve veće interesovanje za primenom specifičnih nanonosača  antigena,  kao  što  su  nanoemulzije,  kako  bi  se  antigeni  zaštitili  od  preuranjene proteolitičke  degradacije  i/ili poboljšala  njihova  imunogenost,  olakšavanjem  preuzimanja  i obrade  od  strane  antigen-prezentujućih  ćelija.  Takođe,  brojni  istraživački  napori  tokom poslednjih nekoliko godina usmereni su ka razvoju inovativnih tehnologija za isporuku antigena u kožu (kao što su mikroigle) radi poboljšanja efikasnosti vakcinacije uz istovremeno povećanje adherence pacijenata, posebno u pedijatrijskoj populaciji (neinvazivan ili minimalno invazivan način primene). Otuda, u ovom preglednom radu dat je detaljan pregled karakteristika svakog od  navedenih  pristupa  za  poboljšanje  efikasnosti  vakcina,  sa  posebnim  osvrtom  na  primere njihove primene u formulacijama vakcina i faktore koji određuju efikasnost i bezbednost.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - Established and advanced adjuvants in vaccines' formulation: Mineral adsorbents, nanoparticulate carriers and microneedle delivery systems
T1  - Konvencionalni i napredni adjuvansi u formulacijama vakcina: mineralni adsorbenti, nanočestični nosači i sistemi tipa mikroigala
VL  - 69
IS  - 6
SP  - 420
EP  - 451
DO  - 10.5937/arhfarm1906420K
ER  - 
@article{
author = "Krajišnik, Danina and Ilić, Tanja and Nikolić, Ines and Savić, Snežana",
year = "2019",
abstract = "In the era of modern vaccinology, limited immunogenicity of the most commonly used antigens has enforced the use of various adjuvants in vaccine formulations to achieve desired immune  response.  Aluminum-containing  adjuvants  have  been,  historically,  the  most  widely used mineral immunostimulants, generally regarded as safe to use in human vaccines. The great academic   progress   in   inorganic   (nano)materials   synthesis,   structure   control   and functionalization design has  led  to  a  growing  interest  in innovative  adjuvants  such  as  clays, mesoporous silica nanoparticles, zinc oxide, iron oxide and iron hydroxide nanoparticles, etc. On the other hand, there has been an intention to use specific nanoparticulated antigen delivery systems,  such  as  nanoemulsions,  in  order  to  protect  antigens  from  premature  proteolytic degradation  and/or  to  improve  antigen  immunogenicity  by  facilitating  antigen  uptake  and processing by antigen presenting cells. Simultaneously, numerous research efforts have been focused on the development of innovative technologies for antigen delivery into the skin (such as microneedles), with the aim to improve vaccine efficacy alongside with enhanced patient adherence,  particularly  in  children  population  (noninvasive  or minimally  invasive administration). Therefore, this review deals with each of these approaches in more detail, with the special emphasis on examples of their use in vaccine formulations as well as on the factors influencing their efficacy and safety., U  doba  savremene  vakcinologije,  ograničena  imunogenost  većine  korišćenih  antigena podstakla  je  primenu  različitih  adjuvanasa  u  formulacijama  vakcina  radi  postizanja  željenog imunskog odgovora. Mineralni adjuvansi na bazi aluminijuma su istorijski najčešće korišćeni imunostimulansi u vakcinama i smatraju se generalno bezbednim za humanu upotrebu. Značajni napredak  na  polju  sinteze,  kontrole  strukture  i  funkcionalnog  dizajna  neorganskih (nano)materijala uslovio je povećano interesovanje za primenom inovativnih adjuvanasa kao što su  gline,  mezoporozne  silika  nanočestice,  nanočestice  cink-oksida,  gvožđe  oksida  i  gvožđe hidroksida, i dr. Sa druge strane, uočava se i sve veće interesovanje za primenom specifičnih nanonosača  antigena,  kao  što  su  nanoemulzije,  kako  bi  se  antigeni  zaštitili  od  preuranjene proteolitičke  degradacije  i/ili poboljšala  njihova  imunogenost,  olakšavanjem  preuzimanja  i obrade  od  strane  antigen-prezentujućih  ćelija.  Takođe,  brojni  istraživački  napori  tokom poslednjih nekoliko godina usmereni su ka razvoju inovativnih tehnologija za isporuku antigena u kožu (kao što su mikroigle) radi poboljšanja efikasnosti vakcinacije uz istovremeno povećanje adherence pacijenata, posebno u pedijatrijskoj populaciji (neinvazivan ili minimalno invazivan način primene). Otuda, u ovom preglednom radu dat je detaljan pregled karakteristika svakog od  navedenih  pristupa  za  poboljšanje  efikasnosti  vakcina,  sa  posebnim  osvrtom  na  primere njihove primene u formulacijama vakcina i faktore koji određuju efikasnost i bezbednost.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Established and advanced adjuvants in vaccines' formulation: Mineral adsorbents, nanoparticulate carriers and microneedle delivery systems, Konvencionalni i napredni adjuvansi u formulacijama vakcina: mineralni adsorbenti, nanočestični nosači i sistemi tipa mikroigala",
volume = "69",
number = "6",
pages = "420-451",
doi = "10.5937/arhfarm1906420K"
}
Krajišnik, D., Ilić, T., Nikolić, I.,& Savić, S.. (2019). Established and advanced adjuvants in vaccines' formulation: Mineral adsorbents, nanoparticulate carriers and microneedle delivery systems. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 69(6), 420-451.
https://doi.org/10.5937/arhfarm1906420K
Krajišnik D, Ilić T, Nikolić I, Savić S. Established and advanced adjuvants in vaccines' formulation: Mineral adsorbents, nanoparticulate carriers and microneedle delivery systems. in Arhiv za farmaciju. 2019;69(6):420-451.
doi:10.5937/arhfarm1906420K .
Krajišnik, Danina, Ilić, Tanja, Nikolić, Ines, Savić, Snežana, "Established and advanced adjuvants in vaccines' formulation: Mineral adsorbents, nanoparticulate carriers and microneedle delivery systems" in Arhiv za farmaciju, 69, no. 6 (2019):420-451,
https://doi.org/10.5937/arhfarm1906420K . .

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceCommunitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB