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dc.creatorWallace, David R.
dc.creatorTaalab, Yasmeen M.
dc.creatorHeinze, Sarah
dc.creatorTariba Lovaković, Sarah
dc.creatorPizent, Alica
dc.creatorRenieri, Elisavit
dc.creatorTsatsakis, Aristidis
dc.creatorFarooqi, Ammad Ahmad
dc.creatorJavorac, Dragana
dc.creatorAnđelković, Milena
dc.creatorBulat, Zorica
dc.creatorAntonijević, Biljana
dc.creatorBuha-Đorđević, Aleksandra
dc.date.accessioned2020-06-01T08:53:25Z
dc.date.available2020-06-01T08:53:25Z
dc.date.issued2020
dc.identifier.issn2073-4409
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3578
dc.description.abstractToxic metals are extensively found in the environment, households, and workplaces and contaminate food and drinking water. The crosstalk between environmental exposure to toxic metals and human diseases has been frequently described. The toxic mechanism of action was classically viewed as the ability to dysregulate the redox status, production of inflammatory mediators and alteration of mitochondrial function. Recently, growing evidence showed that heavy metals might exert their toxicity through microRNAs (miRNA)-short, single-stranded, noncoding molecules that function as positive/negative regulators of gene expression. Aberrant alteration of the endogenous miRNA has been directly implicated in various pathophysiological conditions and signaling pathways, consequently leading to different types of cancer and human diseases. Additionally, the gene-regulatory capacity of miRNAs is particularly valuable in the brain-a complex organ with neurons demonstrating a significant ability to adapt following environmental stimuli. Accordingly, dysregulated miRNAs identified in patients suffering from neurological diseases might serve as biomarkers for the earlier diagnosis and monitoring of disease progression. This review will greatly emphasize the effect of the toxic metals on human miRNA activities and how this contributes to progression of diseases such as cancer and neurodegenerative disorders (NDDs).en
dc.publisherMDPI
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46009/RS//
dc.relationOSUCHS 154357 (to D.R.W.)
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceCells
dc.subjectarsenic
dc.subjectcadmium
dc.subjectcancer
dc.subjectepigenetic modification
dc.subjectgene expression
dc.subjectlead
dc.subjectmanganese
dc.subjectmercury
dc.subjectmiRNA
dc.subjectneurodegenerative diseases (NDDs)
dc.titleToxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Developmenten
dc.typearticle
dc.rights.licenseBY
dcterms.abstractПизент, Aлица; Рениери, Елисавит; Фарооqи, Aммад Aхмад; Wаллаце, Давид Р.; Таалаб, Yасмеен М.; Хеинзе, Сарах; Тариба Ловаковић, Сарах; Буха-Ђорђевић, Aлександра; Aнтонијевић, Биљана; Булат, Зорица; Aнђелковић, Милена; Јаворац, Драгана; Тсатсакис, Aристидис;
dc.citation.volume9
dc.citation.issue4
dc.citation.rankM21
dc.identifier.wos000535559500112
dc.identifier.doi10.3390/cells9040901
dc.identifier.scopus2-s2.0-85083170290
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/7696/Toxic-Metal-Induced_Alteration_in_pub_2020.pdf
dc.type.versionpublishedVersion


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