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dc.creatorMiljković, Nenad
dc.creatorGodman, Brian
dc.creatorKovačević, Milena
dc.creatorPolidori, Piera
dc.creatorTzimis, Leonidas
dc.creatorHoppe-Tichy, Torsten
dc.creatorSaar, Marika
dc.creatorAntofie, Ioan
dc.creatorHorvath, Laszlo
dc.creatorDe Rijdt, Thomas
dc.creatorVida, Róbert György
dc.creatorKkolou, Elena
dc.creatorPreece, David
dc.creatorTubić, Biljana
dc.creatorPeppard, Joan
dc.creatorMartinez, Alicia
dc.creatorYubero, Cristina Garcia
dc.creatorHaddad, Ratiba
dc.creatorRajinac, Dragana
dc.creatorZelić, Pavle
dc.creatorJenzer, Helena
dc.creatorTartar, Franci
dc.creatorGitler, Gunda
dc.creatorJeske, Martina
dc.creatorDavidescu, Michal
dc.creatorBeraud, Michal
dc.creatorKuruc-Poje, Darija
dc.creatorHaag, Sakstrup Haag
dc.creatorFischer, Hanne
dc.creatorSviestina, Inese
dc.creatorLjubojević, Gordana
dc.creatorMarkestad, Anne
dc.creatorVujić-Aleksić, Vesna
dc.creatorNežić, Lana
dc.creatorCrkvenčić, Anica
dc.creatorLinnolahti, Johanna
dc.creatorAšanin, Bogdan
dc.creatorDuborija-Kovačević, Nataša
dc.creatorBochenek, Tomasz
dc.creatorHuys, Isabelle
dc.creatorMiljković, Branislava
dc.date.accessioned2020-06-02T09:07:46Z
dc.date.available2020-06-02T09:07:46Z
dc.date.issued2020
dc.identifier.issn1663-9812
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3586
dc.description.abstractIntroduction: While medicine shortages are complex, their mitigation is more of a challenge. Prospective risk assessment as a means to mitigate possible shortages, has yet to be applied equally across healthcare settings. The aims of this study have been to: 1) gain insight into risk-prevention against possible medicine shortages among healthcare experts; 2) review existing strategies for minimizing patient-health risks through applied risk assessment; and 3) learn from experiences related to application in practice. Methodology: A semi-structured questionnaire focusing on medicine shortages was distributed electronically to members of the European Cooperation in Science and Technology (COST) Action 15105 (28 member countries) and to hospital pharmacists of the European Association of Hospital Pharmacists (EAHP) (including associated healthcare professionals). Their answers were subjected to both qualitative and quantitative analysis (Microsoft Office Excel 2010 and IBM SPSS Statistics®) with descriptive statistics based on the distribution of responses. Their proportional difference was tested by the chi-square test and Fisher's exact test for independence. Differences in the observed ordinal variables were tested by the Mann-Whitney or Kruskal-Wallis test. The qualitative data were tabulated and recombined with the quantitative data to observe, uncover and interpret meanings and patterns. Results: The participants (61.7%) are aware of the use of risk assessment procedures as a coping strategy for medicine shortages, and named the particular risk assessment procedure they are familiar with failure mode and effect analysis (FMEA) (26.4%), root cause analysis (RCA) (23.5%), the healthcare FMEA (HFMEA) (14.7%), and the hazard analysis and critical control point (HACCP) (14.7%). Only 29.4% report risk assessment as integrated into mitigation strategy protocols. Risk assessment is typically conducted within multidisciplinary teams (35.3%). Whereas 14.7% participants were aware of legislation stipulating risk assessment implementation in shortages, 88.2% claimed not to have reported their findings to their respective official institutions. 85.3% consider risk assessment a useful mitigation strategy. Conclusion: The study indicates a lack of systematically organized tools used to prospectively analyze clinical as well as operationalized risk stemming from medicine shortages in healthcare. There is also a lack of legal instruments and sufficient data confirming the necessity and usefulness of risk assessment in mitigating medicine shortages in Europe. © Copyright © 2020 Miljković, Godman, Kovačević, Polidori, Tzimis, Hoppe-Tichy, Saar, Antofie, Horvath, De Rijdt, Vida, Kkolou, Preece, Tubić, Peppard, Martinez, Yubero, Haddad, Rajinac, Zelić, Jenzer, Tartar, Gitler, Jeske, Davidescu, Beraud, Kuruc-Poje, Haag, Fischer, Sviestina, Ljubojević, Markestad, Vujić-Aleksić, Nežić, Crkvenčić, Linnolahti, Ašanin, Duborija-Kovačević, Bochenek, Huys and Miljković.en
dc.publisherFrontiers Media S.A.
dc.relationCOST Action CA 15105 [European Medicines Shortages Research Network
dc.relationCOST (European Cooperation in Science and Technology)
dc.rightsopenAccess
dc.sourceFrontiers in Pharmacology
dc.subjectEurope
dc.subjectmedicine shortage
dc.subjectmitigation strategy
dc.subjectrisk assessment
dc.subjectsubstitution
dc.subjectMedicine: Pharmacology (medical)
dc.subjectPharmacology, Toxicology and Pharmaceutics: Pharmacology
dc.titleProspective Risk Assessment of Medicine Shortages in Europe and Israel: Findings and Implicationsen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractГодман, Бриан; Миљковић, Ненад; Ковачевић, Милена; Тубић, Биљана; Љубојевић, Гордана; Миљковић, Бранислава; Полидори, Пиера; Тзимис, Леонидас; Хоппе-Тицхy, Торстен; Саар, Марика; Aнтофие, Иоан; Хорватх, Ласзло; Де Ријдт, Тхомас; Вида, Рóберт Гyöргy; Кколоу, Елена; Прееце, Давид; Пеппард, Јоан; Мартинез, Aлициа; Yуберо, Цристина Гарциа; Хаддад, Ратиба; Рајинац, Драгана; Зелић, Павле; Јензер, Хелена; Тартар, Франци; Гитлер, Гунда; Јеске, Мартина; Давидесцу, Мицхал; Берауд, Мицхал; Куруц-Поје, Дарија; Хааг, Сакструп Хааг; Фисцхер, Ханне; Свиестина, Инесе; Маркестад, Aнне; Вујић-Aлексић, Весна; Нежић, Лана; Црквенчић, Aница; Линнолахти, Јоханна; Aшанин, Богдан; Дуборија-Ковачевић, Наташа; Боцхенек, Томасз; Хуyс, Исабелле; Проспецтиве Риск Aссессмент оф Медицине Схортагес ин Еуропе анд Исраел: Финдингс анд Имплицатионс;
dc.citation.volume11
dc.citation.rankM21~
dc.identifier.wos000526919700001
dc.identifier.doi10.3389/fphar.2020.00357
dc.identifier.scopus2-s2.0-85083242118
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/7722/Prospective_Risk_Assessment_pub_2020.pdf
dc.type.versionpublishedVersion


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