Endocan and a novel score for dyslipidemia, oxidative stress and inflammation (DOI score) are independently correlated with glycated hemoglobin (HbA1c) in patients with prediabetes and type 2 diabetes
Authors
Klisić, Aleksandra
Kavarić, Nebojša
Stanišić, Verica
Milović, Sanja
Spasojević-Kalimanovska, Vesna

Ninić, Ana

Kotur-Stevuljević, Jelena

Article (Published version)
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Introduction: We aimed to examine serum endocan level and the summary involvement of dyslipidemia, oxidative stress (OS) and inflammation by calculation of its comprehensive score (i.e. Dyslipidemia-Oxy-Inflammation (DOI) score) in relation to glucoregulation in subjects with prediabetes and overt type 2 diabetes (T2D). Material and methods: A total of 59 patients with prediabetes and 102 patients with T2D were compared with 117 diabetes-free controls. Glycated hemoglobin (HbA1c), inflammation, OS and lipid parameters were measured. Associations of clinical data with HbA1c level were tested with univariate and multivariate logistic ordinal regression analysis. HbA1c as a dependent variable is given at the ordinal level (i.e. < 5.7%; 5.7-6.4%, > 6.4%, respectively). Results: Endocan was significantly higher in the T2D group than in the controls. As endocan concentration rose by 1 unit, the probability for higher HbA1c concentration increased by more than 3 times (OR = 3.69, 95% CI: 1.84...-7.01, p < 0.001). Also, a rise in the dyslipidemia score, oxy score, inflammation score and DOI score by 1 unit increased the probability of higher HbA1c concentration by 19%, 13%, 51% and 11%, respectively. In the models, after adjustment for confounding variables, endocan and DOI score remained independent predictors of HbA1c level. Conclusions: Endocan and DOI score are independently correlated with HbA1c in patients with prediabetes and overt T2D.
Keywords:
Oxidative stress / Inflammation / Diabetes / Endocan / Glycemic controlSource:
Archives of Medical Science, 2020, 16, 1, 42-50Publisher:
- Termedia Publishing House Ltd.
Funding / projects:
DOI: 10.5114/aoms.2019.87541
ISSN: 1734-1922
WoS: 000505030200006
Scopus: 2-s2.0-85075754205
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PharmacyTY - JOUR AU - Klisić, Aleksandra AU - Kavarić, Nebojša AU - Stanišić, Verica AU - Milović, Sanja AU - Spasojević-Kalimanovska, Vesna AU - Ninić, Ana AU - Kotur-Stevuljević, Jelena PY - 2020 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3601 AB - Introduction: We aimed to examine serum endocan level and the summary involvement of dyslipidemia, oxidative stress (OS) and inflammation by calculation of its comprehensive score (i.e. Dyslipidemia-Oxy-Inflammation (DOI) score) in relation to glucoregulation in subjects with prediabetes and overt type 2 diabetes (T2D). Material and methods: A total of 59 patients with prediabetes and 102 patients with T2D were compared with 117 diabetes-free controls. Glycated hemoglobin (HbA1c), inflammation, OS and lipid parameters were measured. Associations of clinical data with HbA1c level were tested with univariate and multivariate logistic ordinal regression analysis. HbA1c as a dependent variable is given at the ordinal level (i.e. < 5.7%; 5.7-6.4%, > 6.4%, respectively). Results: Endocan was significantly higher in the T2D group than in the controls. As endocan concentration rose by 1 unit, the probability for higher HbA1c concentration increased by more than 3 times (OR = 3.69, 95% CI: 1.84-7.01, p < 0.001). Also, a rise in the dyslipidemia score, oxy score, inflammation score and DOI score by 1 unit increased the probability of higher HbA1c concentration by 19%, 13%, 51% and 11%, respectively. In the models, after adjustment for confounding variables, endocan and DOI score remained independent predictors of HbA1c level. Conclusions: Endocan and DOI score are independently correlated with HbA1c in patients with prediabetes and overt T2D. PB - Termedia Publishing House Ltd. T2 - Archives of Medical Science T1 - Endocan and a novel score for dyslipidemia, oxidative stress and inflammation (DOI score) are independently correlated with glycated hemoglobin (HbA1c) in patients with prediabetes and type 2 diabetes VL - 16 IS - 1 SP - 42 EP - 50 DO - 10.5114/aoms.2019.87541 ER -
@article{ author = "Klisić, Aleksandra and Kavarić, Nebojša and Stanišić, Verica and Milović, Sanja and Spasojević-Kalimanovska, Vesna and Ninić, Ana and Kotur-Stevuljević, Jelena", year = "2020", abstract = "Introduction: We aimed to examine serum endocan level and the summary involvement of dyslipidemia, oxidative stress (OS) and inflammation by calculation of its comprehensive score (i.e. Dyslipidemia-Oxy-Inflammation (DOI) score) in relation to glucoregulation in subjects with prediabetes and overt type 2 diabetes (T2D). Material and methods: A total of 59 patients with prediabetes and 102 patients with T2D were compared with 117 diabetes-free controls. Glycated hemoglobin (HbA1c), inflammation, OS and lipid parameters were measured. Associations of clinical data with HbA1c level were tested with univariate and multivariate logistic ordinal regression analysis. HbA1c as a dependent variable is given at the ordinal level (i.e. < 5.7%; 5.7-6.4%, > 6.4%, respectively). Results: Endocan was significantly higher in the T2D group than in the controls. As endocan concentration rose by 1 unit, the probability for higher HbA1c concentration increased by more than 3 times (OR = 3.69, 95% CI: 1.84-7.01, p < 0.001). Also, a rise in the dyslipidemia score, oxy score, inflammation score and DOI score by 1 unit increased the probability of higher HbA1c concentration by 19%, 13%, 51% and 11%, respectively. In the models, after adjustment for confounding variables, endocan and DOI score remained independent predictors of HbA1c level. Conclusions: Endocan and DOI score are independently correlated with HbA1c in patients with prediabetes and overt T2D.", publisher = "Termedia Publishing House Ltd.", journal = "Archives of Medical Science", title = "Endocan and a novel score for dyslipidemia, oxidative stress and inflammation (DOI score) are independently correlated with glycated hemoglobin (HbA1c) in patients with prediabetes and type 2 diabetes", volume = "16", number = "1", pages = "42-50", doi = "10.5114/aoms.2019.87541" }
Klisić, A., Kavarić, N., Stanišić, V., Milović, S., Spasojević-Kalimanovska, V., Ninić, A.,& Kotur-Stevuljević, J.. (2020). Endocan and a novel score for dyslipidemia, oxidative stress and inflammation (DOI score) are independently correlated with glycated hemoglobin (HbA1c) in patients with prediabetes and type 2 diabetes. in Archives of Medical Science Termedia Publishing House Ltd.., 16(1), 42-50. https://doi.org/10.5114/aoms.2019.87541
Klisić A, Kavarić N, Stanišić V, Milović S, Spasojević-Kalimanovska V, Ninić A, Kotur-Stevuljević J. Endocan and a novel score for dyslipidemia, oxidative stress and inflammation (DOI score) are independently correlated with glycated hemoglobin (HbA1c) in patients with prediabetes and type 2 diabetes. in Archives of Medical Science. 2020;16(1):42-50. doi:10.5114/aoms.2019.87541 .
Klisić, Aleksandra, Kavarić, Nebojša, Stanišić, Verica, Milović, Sanja, Spasojević-Kalimanovska, Vesna, Ninić, Ana, Kotur-Stevuljević, Jelena, "Endocan and a novel score for dyslipidemia, oxidative stress and inflammation (DOI score) are independently correlated with glycated hemoglobin (HbA1c) in patients with prediabetes and type 2 diabetes" in Archives of Medical Science, 16, no. 1 (2020):42-50, https://doi.org/10.5114/aoms.2019.87541 . .