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dc.creatorLalić-Ćosić, Sanja
dc.creatorDopsaj, Violeta
dc.creatorKovač, Mirjana
dc.creatorPruner, Iva
dc.creatorLittmann, Karin
dc.creatorMandić-Marković, Vesna
dc.creatorMiković, Željko
dc.creatorAntović, Aleksandra
dc.date.accessioned2020-06-15T11:24:29Z
dc.date.available2020-06-15T11:24:29Z
dc.date.issued2020
dc.identifier.issn1751-5521
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3609
dc.description.abstractIntroduction: Haemostatic balance shifted towards hypercoagulability in normal pregnancy is even more pronounced in pre-eclampsia (P-EC). The aim of this study was to analyse haemostatic disturbances and fibrin clot properties in women with pre-eclampsia and to investigate their association with maternal and foetal outcomes. Methods: Forty-six pregnant women diagnosed with pre-eclampsia were included in the study, with blood sampling done on the morning following admission to hospital, as well as after delivery (mean duration 4.8 days). Two global haemostatic assays—endogenous thrombin potential (ETP) and assay of overall haemostatic potential (OHP)—were employed, including fibrin clot turbidity measurements and scanning electron microscopy (SEM) of representative samples. Results: Three thrombin generation parameters (ETP, t_lag and peak height) and OHP were significantly increased in pre-eclampsia compared with controls, whereas overall fibrinolytic potential (OFP—determined as a parameter of the OHP assay) had significantly lower values. Clot lysis time was significantly prolonged in patients with pre-eclampsia. In the pre-eclamptic group after delivery, we observed a significant elevation in the peak height and a reduction in the time to peak and OFP compared with values before delivery. Pre-eclamptic patients with renal complications had significantly higher values for ETP, peak height and D-dimer. Turbidity measurements and SEM revealed dense fibrin structure in patients with pre-eclampsia. Conclusion: Patients with pre-eclampsia have enhanced coagulation and impaired fibrinolysis before, and even after, delivery. In particular, the presence of multi-organ dysfunction, such as renal dysfunction, may be associated with increased thrombin generation in pre-eclampsia.en
dc.publisherWiley-Blackwell
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Laboratory Hematology
dc.subjectendogenous thrombin potential
dc.subjectfibrin structure
dc.subjecthaemostasis
dc.subjectoverall haemostatic potential
dc.subjectpre-eclampsia
dc.titleEvaluation of global haemostatic assays and fibrin structure in patients with pre-eclampsiaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМиковић, Жељко; Лалић-Ћосић, Сања; Допсај, Виолета; Мандић-Марковић, Весна; Aнтовић, Aлександра; Ковач, Мирјана; Прунер, Ива; Литтманн, Карин;
dc.citation.volume42
dc.citation.issue3
dc.citation.spage322
dc.citation.epage330
dc.citation.rankM23
dc.identifier.wos000520544100001
dc.identifier.doi10.1111/ijlh.13183
dc.identifier.scopus2-s2.0-85082040715
dc.type.versionpublishedVersion


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Приказ основних података о документу