Oxidative Stress and Inflammatory Markers PTX3, CypA, and HB-EGF: How Are They Linked in Patients With STEMI?
Authors
Vuković Dejanović, Vesna
Kotur-Stevuljević, Jelena

Vukašinović, Aleksandra
Miljković, Milica

Kafedžić, Srđan
Zdravković, Marija
Ilić, Ivan
Hinić, Saša
Cerović, Milivoje
Stefanović, Milica
Spasojević-Kalimanovska, Vesna

Memon, Lidija

Nešković, Aleksandar
Bogavac-Stanojević, Nataša

Article (Published version)
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We investigated circulating levels of inflammatory biomarkers pentraxin-3 (PTX3), cyclophilin A (CypA), and heparin-binding epidermal growth factor-like growth factor (HB-EGF); oxidative stress; and antioxidant status markers in the patients with ST-segment elevation acute myocardial infarction (STEMI) to better understand a relationship between inflammation and oxidative stress. We examined the impact of oxidative stress on high values of inflammatory parameters. The study included 87 patients with STEMI and 193 controls. We observed a positive correlation between PTX3 and HB-EGF (ρ = 0.24, P = .027), CyPA, and sulfhydryl (SH) groups (ρ = 0.25, P = .026), and a negative correlation between PTX3 and SH groups (ρ = −0.35, P = .001) in patients with STEMI. To better understand the effect of the examined parameters on the occurrence of high concentrations of inflammatory parameters, we grouped them using principal component analysis. This analysis identified the 4 most contributing factor...s. Optimal cutoff values for discrimination of patients with STEMI from controls were calculated for PTX3 and HB-EGF. An independent predictor for PTX3 above the cutoff value was a “metabolic-oxidative stress factor” comprised of glucose and oxidative stress marker prooxidant-antioxidant balance (odds ratio = 4.449, P = .030). The results show that higher PTX3 values will occur in patients having STEMI with greater metabolic and oxidative stress status values.
Keywords:
cyclophilin A / heparin-binding EGF-like growth factor / oxidative stress / pentraxin-3 / ST-segment elevation acute myocardial infarctionSource:
Angiology, 2020, 71, 8, 713-720Publisher:
- SAGE journals
Funding / projects:
DOI: 10.1177/0003319720921724
ISSN: 0003-3197
WoS: 000533946400001
Scopus: 2-s2.0-85086022498
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PharmacyTY - JOUR AU - Vuković Dejanović, Vesna AU - Kotur-Stevuljević, Jelena AU - Vukašinović, Aleksandra AU - Miljković, Milica AU - Kafedžić, Srđan AU - Zdravković, Marija AU - Ilić, Ivan AU - Hinić, Saša AU - Cerović, Milivoje AU - Stefanović, Milica AU - Spasojević-Kalimanovska, Vesna AU - Memon, Lidija AU - Nešković, Aleksandar AU - Bogavac-Stanojević, Nataša PY - 2020 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3612 AB - We investigated circulating levels of inflammatory biomarkers pentraxin-3 (PTX3), cyclophilin A (CypA), and heparin-binding epidermal growth factor-like growth factor (HB-EGF); oxidative stress; and antioxidant status markers in the patients with ST-segment elevation acute myocardial infarction (STEMI) to better understand a relationship between inflammation and oxidative stress. We examined the impact of oxidative stress on high values of inflammatory parameters. The study included 87 patients with STEMI and 193 controls. We observed a positive correlation between PTX3 and HB-EGF (ρ = 0.24, P = .027), CyPA, and sulfhydryl (SH) groups (ρ = 0.25, P = .026), and a negative correlation between PTX3 and SH groups (ρ = −0.35, P = .001) in patients with STEMI. To better understand the effect of the examined parameters on the occurrence of high concentrations of inflammatory parameters, we grouped them using principal component analysis. This analysis identified the 4 most contributing factors. Optimal cutoff values for discrimination of patients with STEMI from controls were calculated for PTX3 and HB-EGF. An independent predictor for PTX3 above the cutoff value was a “metabolic-oxidative stress factor” comprised of glucose and oxidative stress marker prooxidant-antioxidant balance (odds ratio = 4.449, P = .030). The results show that higher PTX3 values will occur in patients having STEMI with greater metabolic and oxidative stress status values. PB - SAGE journals T2 - Angiology T1 - Oxidative Stress and Inflammatory Markers PTX3, CypA, and HB-EGF: How Are They Linked in Patients With STEMI? VL - 71 IS - 8 SP - 713 EP - 720 DO - 10.1177/0003319720921724 ER -
@article{ author = "Vuković Dejanović, Vesna and Kotur-Stevuljević, Jelena and Vukašinović, Aleksandra and Miljković, Milica and Kafedžić, Srđan and Zdravković, Marija and Ilić, Ivan and Hinić, Saša and Cerović, Milivoje and Stefanović, Milica and Spasojević-Kalimanovska, Vesna and Memon, Lidija and Nešković, Aleksandar and Bogavac-Stanojević, Nataša", year = "2020", abstract = "We investigated circulating levels of inflammatory biomarkers pentraxin-3 (PTX3), cyclophilin A (CypA), and heparin-binding epidermal growth factor-like growth factor (HB-EGF); oxidative stress; and antioxidant status markers in the patients with ST-segment elevation acute myocardial infarction (STEMI) to better understand a relationship between inflammation and oxidative stress. We examined the impact of oxidative stress on high values of inflammatory parameters. The study included 87 patients with STEMI and 193 controls. We observed a positive correlation between PTX3 and HB-EGF (ρ = 0.24, P = .027), CyPA, and sulfhydryl (SH) groups (ρ = 0.25, P = .026), and a negative correlation between PTX3 and SH groups (ρ = −0.35, P = .001) in patients with STEMI. To better understand the effect of the examined parameters on the occurrence of high concentrations of inflammatory parameters, we grouped them using principal component analysis. This analysis identified the 4 most contributing factors. Optimal cutoff values for discrimination of patients with STEMI from controls were calculated for PTX3 and HB-EGF. An independent predictor for PTX3 above the cutoff value was a “metabolic-oxidative stress factor” comprised of glucose and oxidative stress marker prooxidant-antioxidant balance (odds ratio = 4.449, P = .030). The results show that higher PTX3 values will occur in patients having STEMI with greater metabolic and oxidative stress status values.", publisher = "SAGE journals", journal = "Angiology", title = "Oxidative Stress and Inflammatory Markers PTX3, CypA, and HB-EGF: How Are They Linked in Patients With STEMI?", volume = "71", number = "8", pages = "713-720", doi = "10.1177/0003319720921724" }
Vuković Dejanović, V., Kotur-Stevuljević, J., Vukašinović, A., Miljković, M., Kafedžić, S., Zdravković, M., Ilić, I., Hinić, S., Cerović, M., Stefanović, M., Spasojević-Kalimanovska, V., Memon, L., Nešković, A.,& Bogavac-Stanojević, N.. (2020). Oxidative Stress and Inflammatory Markers PTX3, CypA, and HB-EGF: How Are They Linked in Patients With STEMI?. in Angiology SAGE journals., 71(8), 713-720. https://doi.org/10.1177/0003319720921724
Vuković Dejanović V, Kotur-Stevuljević J, Vukašinović A, Miljković M, Kafedžić S, Zdravković M, Ilić I, Hinić S, Cerović M, Stefanović M, Spasojević-Kalimanovska V, Memon L, Nešković A, Bogavac-Stanojević N. Oxidative Stress and Inflammatory Markers PTX3, CypA, and HB-EGF: How Are They Linked in Patients With STEMI?. in Angiology. 2020;71(8):713-720. doi:10.1177/0003319720921724 .
Vuković Dejanović, Vesna, Kotur-Stevuljević, Jelena, Vukašinović, Aleksandra, Miljković, Milica, Kafedžić, Srđan, Zdravković, Marija, Ilić, Ivan, Hinić, Saša, Cerović, Milivoje, Stefanović, Milica, Spasojević-Kalimanovska, Vesna, Memon, Lidija, Nešković, Aleksandar, Bogavac-Stanojević, Nataša, "Oxidative Stress and Inflammatory Markers PTX3, CypA, and HB-EGF: How Are They Linked in Patients With STEMI?" in Angiology, 71, no. 8 (2020):713-720, https://doi.org/10.1177/0003319720921724 . .