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dc.creatorVuković Dejanović, Vesna
dc.creatorKotur-Stevuljević, Jelena
dc.creatorVukašinović, Aleksandra
dc.creatorMiljković, Milica
dc.creatorKafedžić, Srđan
dc.creatorZdravković, Marija
dc.creatorIlić, Ivan
dc.creatorHinić, Saša
dc.creatorCerović, Milivoje
dc.creatorStefanović, Milica
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorMemon, Lidija
dc.creatorNešković, Aleksandar
dc.creatorBogavac-Stanojević, Nataša
dc.date.accessioned2020-06-17T09:45:55Z
dc.date.available2020-06-17T09:45:55Z
dc.date.issued2020
dc.identifier.issn0003-3197
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3612
dc.description.abstractWe investigated circulating levels of inflammatory biomarkers pentraxin-3 (PTX3), cyclophilin A (CypA), and heparin-binding epidermal growth factor-like growth factor (HB-EGF); oxidative stress; and antioxidant status markers in the patients with ST-segment elevation acute myocardial infarction (STEMI) to better understand a relationship between inflammation and oxidative stress. We examined the impact of oxidative stress on high values of inflammatory parameters. The study included 87 patients with STEMI and 193 controls. We observed a positive correlation between PTX3 and HB-EGF (ρ = 0.24, P = .027), CyPA, and sulfhydryl (SH) groups (ρ = 0.25, P = .026), and a negative correlation between PTX3 and SH groups (ρ = −0.35, P = .001) in patients with STEMI. To better understand the effect of the examined parameters on the occurrence of high concentrations of inflammatory parameters, we grouped them using principal component analysis. This analysis identified the 4 most contributing factors. Optimal cutoff values for discrimination of patients with STEMI from controls were calculated for PTX3 and HB-EGF. An independent predictor for PTX3 above the cutoff value was a “metabolic-oxidative stress factor” comprised of glucose and oxidative stress marker prooxidant-antioxidant balance (odds ratio = 4.449, P = .030). The results show that higher PTX3 values will occur in patients having STEMI with greater metabolic and oxidative stress status values.
dc.publisherSAGE journals
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.sourceAngiology
dc.subjectcyclophilin A
dc.subjectheparin-binding EGF-like growth factor
dc.subjectoxidative stress
dc.subjectpentraxin-3
dc.subjectST-segment elevation acute myocardial infarction
dc.titleOxidative Stress and Inflammatory Markers PTX3, CypA, and HB-EGF: How Are They Linked in Patients With STEMI?
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractБогавац-Станојевић, Наташа; Кафедзиц, Срђан; Здравковић, Марија; Илић, Иван; Хинић, Саша; Церовић, Миливоје; Стефановић, Милица; Нешковић, Aлександар; Котур-Стевуљевић, Јелена; Вукашиновић, Aлександра; Миљковић, Милица; Спасојевић-Калимановска, Весна; Мемон, Лидија; Вуковић Дејановић, Весна;
dc.citation.volume71
dc.citation.issue8
dc.citation.spage713
dc.citation.epage720
dc.identifier.wos000533946400001
dc.identifier.doi10.1177/0003319720921724
dc.identifier.scopus2-s2.0-85086022498
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/8061/Oxidative_Stress_and_pub_2020.pdf
dc.type.versionpublishedVersion


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