Paraoxonase 1 and atherosclerosis-related diseases
rcub.bitstream.locked
2020
Authors
Kotur-Stevuljević, Jelena
Vekić, Jelena

Stefanović, Aleksandra

Zeljković, Aleksandra

Ninić, Ana

Ivanišević, Jasmina

Miljković, Milica

Sopić, Miron

Munjas, Jelena

Mihajlović, Marija

Spasić, Slavica
Jelić-Ivanović, Zorana

Spasojević-Kalimanovska, Vesna

Article (Published version)

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Show full item recordAbstract
A direct and an indirect relationship between paraoxonase 1 (PON1) and atherosclerosis exists. Given PON1's physical location within high-density lipoprotein (HDL) particles and its recognized enzyme activity, it is certainly reasonable to suggest that PON1 facilitates the antiatherogenic nature of HDL particles. PON1 also plays a role in regulating reverse cholesterol transport, antioxidative, anti-inflammatory, antiapoptotic, vasodilative, and antithrombotic activities and several endothelial cell functions. HDL dysfunctionality is a more recent issue and seems to be centered on pathological conditions affecting HDL structure and size profiles. This review is focused on the role of PON1 status in different atherosclerosis-related diseases that we have studied over the last twenty years (coronary heart disease, acute ischemic stroke, diabetes mellitus type 2, end-stage renal disease, chronic obstructive pulmonary disease, and sarcoidosis) with the aim to determine the true value of PO...N1 as a biomarker. The role of PON1 in cancer is also covered, as risk factors and mechanisms underlying both atherosclerosis and cancer share common features. © 2019 International Union of Biochemistry and Molecular Biology
Keywords:
cancer / atherosclerosis / cardiovascular disease / diabetes / HDL dysfunction / paraoxonase 1 / renal disease / strokeSource:
BioFactors, 2020, 46, 2, 193-205Publisher:
- Blackwell Publishing Inc.
Funding / projects:
DOI: 10.1002/biof.1549
ISSN: 0951-6433
WoS: 000480975500001
Scopus: 2-s2.0-85070335419
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Institution/Community
PharmacyTY - JOUR AU - Kotur-Stevuljević, Jelena AU - Vekić, Jelena AU - Stefanović, Aleksandra AU - Zeljković, Aleksandra AU - Ninić, Ana AU - Ivanišević, Jasmina AU - Miljković, Milica AU - Sopić, Miron AU - Munjas, Jelena AU - Mihajlović, Marija AU - Spasić, Slavica AU - Jelić-Ivanović, Zorana AU - Spasojević-Kalimanovska, Vesna PY - 2020 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3615 AB - A direct and an indirect relationship between paraoxonase 1 (PON1) and atherosclerosis exists. Given PON1's physical location within high-density lipoprotein (HDL) particles and its recognized enzyme activity, it is certainly reasonable to suggest that PON1 facilitates the antiatherogenic nature of HDL particles. PON1 also plays a role in regulating reverse cholesterol transport, antioxidative, anti-inflammatory, antiapoptotic, vasodilative, and antithrombotic activities and several endothelial cell functions. HDL dysfunctionality is a more recent issue and seems to be centered on pathological conditions affecting HDL structure and size profiles. This review is focused on the role of PON1 status in different atherosclerosis-related diseases that we have studied over the last twenty years (coronary heart disease, acute ischemic stroke, diabetes mellitus type 2, end-stage renal disease, chronic obstructive pulmonary disease, and sarcoidosis) with the aim to determine the true value of PON1 as a biomarker. The role of PON1 in cancer is also covered, as risk factors and mechanisms underlying both atherosclerosis and cancer share common features. © 2019 International Union of Biochemistry and Molecular Biology PB - Blackwell Publishing Inc. T2 - BioFactors T1 - Paraoxonase 1 and atherosclerosis-related diseases VL - 46 IS - 2 SP - 193 EP - 205 DO - 10.1002/biof.1549 ER -
@article{ author = "Kotur-Stevuljević, Jelena and Vekić, Jelena and Stefanović, Aleksandra and Zeljković, Aleksandra and Ninić, Ana and Ivanišević, Jasmina and Miljković, Milica and Sopić, Miron and Munjas, Jelena and Mihajlović, Marija and Spasić, Slavica and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna", year = "2020", abstract = "A direct and an indirect relationship between paraoxonase 1 (PON1) and atherosclerosis exists. Given PON1's physical location within high-density lipoprotein (HDL) particles and its recognized enzyme activity, it is certainly reasonable to suggest that PON1 facilitates the antiatherogenic nature of HDL particles. PON1 also plays a role in regulating reverse cholesterol transport, antioxidative, anti-inflammatory, antiapoptotic, vasodilative, and antithrombotic activities and several endothelial cell functions. HDL dysfunctionality is a more recent issue and seems to be centered on pathological conditions affecting HDL structure and size profiles. This review is focused on the role of PON1 status in different atherosclerosis-related diseases that we have studied over the last twenty years (coronary heart disease, acute ischemic stroke, diabetes mellitus type 2, end-stage renal disease, chronic obstructive pulmonary disease, and sarcoidosis) with the aim to determine the true value of PON1 as a biomarker. The role of PON1 in cancer is also covered, as risk factors and mechanisms underlying both atherosclerosis and cancer share common features. © 2019 International Union of Biochemistry and Molecular Biology", publisher = "Blackwell Publishing Inc.", journal = "BioFactors", title = "Paraoxonase 1 and atherosclerosis-related diseases", volume = "46", number = "2", pages = "193-205", doi = "10.1002/biof.1549" }
Kotur-Stevuljević, J., Vekić, J., Stefanović, A., Zeljković, A., Ninić, A., Ivanišević, J., Miljković, M., Sopić, M., Munjas, J., Mihajlović, M., Spasić, S., Jelić-Ivanović, Z.,& Spasojević-Kalimanovska, V.. (2020). Paraoxonase 1 and atherosclerosis-related diseases. in BioFactors Blackwell Publishing Inc.., 46(2), 193-205. https://doi.org/10.1002/biof.1549
Kotur-Stevuljević J, Vekić J, Stefanović A, Zeljković A, Ninić A, Ivanišević J, Miljković M, Sopić M, Munjas J, Mihajlović M, Spasić S, Jelić-Ivanović Z, Spasojević-Kalimanovska V. Paraoxonase 1 and atherosclerosis-related diseases. in BioFactors. 2020;46(2):193-205. doi:10.1002/biof.1549 .
Kotur-Stevuljević, Jelena, Vekić, Jelena, Stefanović, Aleksandra, Zeljković, Aleksandra, Ninić, Ana, Ivanišević, Jasmina, Miljković, Milica, Sopić, Miron, Munjas, Jelena, Mihajlović, Marija, Spasić, Slavica, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, "Paraoxonase 1 and atherosclerosis-related diseases" in BioFactors, 46, no. 2 (2020):193-205, https://doi.org/10.1002/biof.1549 . .