Paraoxonase 1 and atherosclerosis-related diseases
Authorized Users Only
2020
Authors
Kotur-Stevuljević, Jelena
Vekić, Jelena

Stefanović, Aleksandra

Zeljković, Aleksandra

Ninić, Ana

Ivanišević, Jasmina

Miljković, Milica

Sopić, Miron

Munjas, Jelena

Mihajlović, Marija

Spasić, Slavica
Jelić-Ivanović, Zorana

Spasojević-Kalimanovska, Vesna

Article (Published version)

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Show full item recordAbstract
A direct and an indirect relationship between paraoxonase 1 (PON1) and atherosclerosis exists. Given PON1's physical location within high-density lipoprotein (HDL) particles and its recognized enzyme activity, it is certainly reasonable to suggest that PON1 facilitates the antiatherogenic nature of HDL particles. PON1 also plays a role in regulating reverse cholesterol transport, antioxidative, anti-inflammatory, antiapoptotic, vasodilative, and antithrombotic activities and several endothelial cell functions. HDL dysfunctionality is a more recent issue and seems to be centered on pathological conditions affecting HDL structure and size profiles. This review is focused on the role of PON1 status in different atherosclerosis-related diseases that we have studied over the last twenty years (coronary heart disease, acute ischemic stroke, diabetes mellitus type 2, end-stage renal disease, chronic obstructive pulmonary disease, and sarcoidosis) with the aim to determine the true value of PO...N1 as a biomarker. The role of PON1 in cancer is also covered, as risk factors and mechanisms underlying both atherosclerosis and cancer share common features. © 2019 International Union of Biochemistry and Molecular Biology
Keywords:
cancer / atherosclerosis / cardiovascular disease / diabetes / HDL dysfunction / paraoxonase 1 / renal disease / strokeSource:
BioFactors, 2020, 46, 2, 193-205Publisher:
- Blackwell Publishing Inc.
Projects:
DOI: 10.1002/biof.1549
ISSN: 0951-6433