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Paraoxonase 1 and atherosclerosis-related diseases
dc.creator | Kotur-Stevuljević, Jelena | |
dc.creator | Vekić, Jelena | |
dc.creator | Stefanović, Aleksandra | |
dc.creator | Zeljković, Aleksandra | |
dc.creator | Ninić, Ana | |
dc.creator | Ivanišević, Jasmina | |
dc.creator | Miljković, Milica | |
dc.creator | Sopić, Miron | |
dc.creator | Munjas, Jelena | |
dc.creator | Mihajlović, Marija | |
dc.creator | Spasić, Slavica | |
dc.creator | Jelić-Ivanović, Zorana | |
dc.creator | Spasojević-Kalimanovska, Vesna | |
dc.date.accessioned | 2020-06-18T10:43:46Z | |
dc.date.available | 2020-06-18T10:43:46Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0951-6433 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3615 | |
dc.description.abstract | A direct and an indirect relationship between paraoxonase 1 (PON1) and atherosclerosis exists. Given PON1's physical location within high-density lipoprotein (HDL) particles and its recognized enzyme activity, it is certainly reasonable to suggest that PON1 facilitates the antiatherogenic nature of HDL particles. PON1 also plays a role in regulating reverse cholesterol transport, antioxidative, anti-inflammatory, antiapoptotic, vasodilative, and antithrombotic activities and several endothelial cell functions. HDL dysfunctionality is a more recent issue and seems to be centered on pathological conditions affecting HDL structure and size profiles. This review is focused on the role of PON1 status in different atherosclerosis-related diseases that we have studied over the last twenty years (coronary heart disease, acute ischemic stroke, diabetes mellitus type 2, end-stage renal disease, chronic obstructive pulmonary disease, and sarcoidosis) with the aim to determine the true value of PON1 as a biomarker. The role of PON1 in cancer is also covered, as risk factors and mechanisms underlying both atherosclerosis and cancer share common features. © 2019 International Union of Biochemistry and Molecular Biology | en |
dc.publisher | Blackwell Publishing Inc. | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS// | |
dc.rights | restrictedAccess | |
dc.source | BioFactors | |
dc.subject | cancer | |
dc.subject | atherosclerosis | |
dc.subject | cardiovascular disease | |
dc.subject | diabetes | |
dc.subject | HDL dysfunction | |
dc.subject | paraoxonase 1 | |
dc.subject | renal disease | |
dc.subject | stroke | |
dc.title | Paraoxonase 1 and atherosclerosis-related diseases | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Спасић, Славица; Јелић-Ивановић, Зорана; Котур-Стевуљевић, Јелена; Векић, Јелена; Стефановић, Aлександра; Зељковић, Aлександра; Спасојевић-Калимановска, Весна; Нинић, Aна; Иванишевић, Јасмина; Миљковић, Милица; Сопић, Мирон; Муњас, Јелена; Михајловић, Марија; | |
dc.citation.volume | 46 | |
dc.citation.issue | 2 | |
dc.citation.spage | 193 | |
dc.citation.epage | 205 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000480975500001 | |
dc.identifier.doi | 10.1002/biof.1549 | |
dc.identifier.scopus | 2-s2.0-85070335419 | |
dc.type.version | publishedVersion |