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Potential drug–drug interactions associated with clinical and laboratory findings at hospital admission

Authorized Users Only
2020
Authors
Kovačević, Milena
Vezmar-Kovačević, Sandra
Radovanović, Slavica
Stevanović, Predrag
Miljković, Branislava
Article (Published version)
Metadata
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Abstract
Background Drug–drug interactions represent one of the causes of adverse therapy outcomes through deteriorated efficacy or safety. However, the true extent of harm related to drug–drug interactions is not well established due to a lack of recognition and understanding. Objective The aim of this study was to investigate the association of potential drug–drug interactions with patients variables recorded at admission. Setting A cross-sectional correlation study was performed on the Cardiology ward of the University Clinical Hospital Center in Belgrade, Serbia. Method Data were retrospectively obtained from medical records and LexiInteract was used as the screening tool for potential drug–drug interactions. Main outcome measure Clinical and laboratory parameters recorded at the patients admission. Results A total of 351 patient records entered the analysis, with the mean age of 70 ± 10 years. The prevalence of potentially relevant drug–drug interactions was 61% (N = 213). After controllin...g for patient characteristics, nine potential drug–drug interactions were significantly associated with laboratory values outside the range and five potential drug–drug interactions with inadequate clinical parameter values. Potential drug–drug interactions were associated with abnormalities in blood count, metabolic parameters, electrolyte imbalance and renal function parameters. Association with inadequate control of systolic, diastolic blood pressure, as well as heart rhythm was also shown. Conclusion Drug–drug interactions were associated with patients clinical and laboratory findings. Our findings may assist in the identification of patients with increased likelihood of suboptimal therapy outcomes. Generating evidence through post-marketing drug–drug interactions research would lead to improvement in clinical decision-support systems, increased effectiveness and utilization in everyday clinical practice.

Keywords:
Adverse drug event / Cardiology / DDI / Drug interactions / Medication safety / Patient safety / Serbia
Source:
International Journal of Clinical Pharmacy, 2020, 42, 1, 150-157
Publisher:
  • Springer
Funding / projects:
  • Basic and Clinical Pharmacological research of mechanisms of action and drug interactions in nervous and cardiovascular system (RS-175023)

DOI: 10.1007/s11096-019-00951-y

ISSN: 2210-7703

WoS: 000526320100020

Scopus: 2-s2.0-85076728265
[ Google Scholar ]
5
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3616
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Kovačević, Milena
AU  - Vezmar-Kovačević, Sandra
AU  - Radovanović, Slavica
AU  - Stevanović, Predrag
AU  - Miljković, Branislava
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3616
AB  - Background Drug–drug interactions represent one of the causes of adverse therapy outcomes through deteriorated efficacy or safety. However, the true extent of harm related to drug–drug interactions is not well established due to a lack of recognition and understanding. Objective The aim of this study was to investigate the association of potential drug–drug interactions with patients variables recorded at admission. Setting A cross-sectional correlation study was performed on the Cardiology ward of the University Clinical Hospital Center in Belgrade, Serbia. Method Data were retrospectively obtained from medical records and LexiInteract was used as the screening tool for potential drug–drug interactions. Main outcome measure Clinical and laboratory parameters recorded at the patients admission. Results A total of 351 patient records entered the analysis, with the mean age of 70 ± 10 years. The prevalence of potentially relevant drug–drug interactions was 61% (N = 213). After controlling for patient characteristics, nine potential drug–drug interactions were significantly associated with laboratory values outside the range and five potential drug–drug interactions with inadequate clinical parameter values. Potential drug–drug interactions were associated with abnormalities in blood count, metabolic parameters, electrolyte imbalance and renal function parameters. Association with inadequate control of systolic, diastolic blood pressure, as well as heart rhythm was also shown. Conclusion Drug–drug interactions were associated with patients clinical and laboratory findings. Our findings may assist in the identification of patients with increased likelihood of suboptimal therapy outcomes. Generating evidence through post-marketing drug–drug interactions research would lead to improvement in clinical decision-support systems, increased effectiveness and utilization in everyday clinical practice.
PB  - Springer
T2  - International Journal of Clinical Pharmacy
T1  - Potential drug–drug interactions associated with clinical and laboratory findings at hospital admission
VL  - 42
IS  - 1
SP  - 150
EP  - 157
DO  - 10.1007/s11096-019-00951-y
ER  - 
@article{
author = "Kovačević, Milena and Vezmar-Kovačević, Sandra and Radovanović, Slavica and Stevanović, Predrag and Miljković, Branislava",
year = "2020",
abstract = "Background Drug–drug interactions represent one of the causes of adverse therapy outcomes through deteriorated efficacy or safety. However, the true extent of harm related to drug–drug interactions is not well established due to a lack of recognition and understanding. Objective The aim of this study was to investigate the association of potential drug–drug interactions with patients variables recorded at admission. Setting A cross-sectional correlation study was performed on the Cardiology ward of the University Clinical Hospital Center in Belgrade, Serbia. Method Data were retrospectively obtained from medical records and LexiInteract was used as the screening tool for potential drug–drug interactions. Main outcome measure Clinical and laboratory parameters recorded at the patients admission. Results A total of 351 patient records entered the analysis, with the mean age of 70 ± 10 years. The prevalence of potentially relevant drug–drug interactions was 61% (N = 213). After controlling for patient characteristics, nine potential drug–drug interactions were significantly associated with laboratory values outside the range and five potential drug–drug interactions with inadequate clinical parameter values. Potential drug–drug interactions were associated with abnormalities in blood count, metabolic parameters, electrolyte imbalance and renal function parameters. Association with inadequate control of systolic, diastolic blood pressure, as well as heart rhythm was also shown. Conclusion Drug–drug interactions were associated with patients clinical and laboratory findings. Our findings may assist in the identification of patients with increased likelihood of suboptimal therapy outcomes. Generating evidence through post-marketing drug–drug interactions research would lead to improvement in clinical decision-support systems, increased effectiveness and utilization in everyday clinical practice.",
publisher = "Springer",
journal = "International Journal of Clinical Pharmacy",
title = "Potential drug–drug interactions associated with clinical and laboratory findings at hospital admission",
volume = "42",
number = "1",
pages = "150-157",
doi = "10.1007/s11096-019-00951-y"
}
Kovačević, M., Vezmar-Kovačević, S., Radovanović, S., Stevanović, P.,& Miljković, B.. (2020). Potential drug–drug interactions associated with clinical and laboratory findings at hospital admission. in International Journal of Clinical Pharmacy
Springer., 42(1), 150-157.
https://doi.org/10.1007/s11096-019-00951-y
Kovačević M, Vezmar-Kovačević S, Radovanović S, Stevanović P, Miljković B. Potential drug–drug interactions associated with clinical and laboratory findings at hospital admission. in International Journal of Clinical Pharmacy. 2020;42(1):150-157.
doi:10.1007/s11096-019-00951-y .
Kovačević, Milena, Vezmar-Kovačević, Sandra, Radovanović, Slavica, Stevanović, Predrag, Miljković, Branislava, "Potential drug–drug interactions associated with clinical and laboratory findings at hospital admission" in International Journal of Clinical Pharmacy, 42, no. 1 (2020):150-157,
https://doi.org/10.1007/s11096-019-00951-y . .

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