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Tableting properties of microcrystalline cellulose obtained from wheat straw measured with a single punch bench top tablet press

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2020
Tableting_properties_of_pub_2020.pdf (1.586Mb)
Authors
Krivokapić, Jovana
Ivanović, Jasna
Đuriš, Jelena
Medarević, Đorđe
Potpara, Zorica
Maksimović, Zoran
Ibrić, Svetlana
Article (Published version)
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Abstract
The objective of this work was to study the relation between the manufacturing conditions of microcrystalline cellulose (MCC), its physicochemical properties and its tableting behavior. Two different preparation procedures were used to produce MCC from wheat straw, utilizing an acid hydrolysis method, either using only sulfuric acid or combination of sulfuric and hydrochloric acid. The tableting behavior of obtained MCC samples and mixtures of MCC with ibuprofen was studied using a dynamic powder compaction analyzer. It was observed that some of the obtained MCC samples showed better flowing properties than commercially available Vivapur® PH101 and also very high values of tensile strength, solid fraction and elastic recovery. This can be linked with its good compaction behavior, but on the other hand it can cause problems with the disintegration of the tablets. In mixtures with ibuprofen, MCC samples showed lower values of tensile strength, while on the other hand elastic recovery did... not seem to be much affected, still exhibiting very high values. According to the obtained results, it can be concluded that MCC obtained from the agricultural waste could have satisfactory properties for tablet preparation by the direct compression method. Further studies are needed to optimize process conditions in order to achieve better physicochemical characteristics, especially in terms of elastic recovery.

Keywords:
Tableting properties / Direct compression / Ibuprofen / Microcrystalline cellulose / Wheat straw
Source:
Saudi Pharmaceutical Journal, 2020, 2, 710-718
Publisher:
  • Elsevier B.V.
Funding / projects:
  • Advanced technologies for controlled release from solid drug delivery systems (RS-34007)

DOI: 10.1016/j.jsps.2020.04.013

ISSN: 1319-0164

WoS: 000540281200011

Scopus: 2-s2.0-85084635770
[ Google Scholar ]
4
2
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3621
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Krivokapić, Jovana
AU  - Ivanović, Jasna
AU  - Đuriš, Jelena
AU  - Medarević, Đorđe
AU  - Potpara, Zorica
AU  - Maksimović, Zoran
AU  - Ibrić, Svetlana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3621
AB  - The objective of this work was to study the relation between the manufacturing conditions of microcrystalline cellulose (MCC), its physicochemical properties and its tableting behavior. Two different preparation procedures were used to produce MCC from wheat straw, utilizing an acid hydrolysis method, either using only sulfuric acid or combination of sulfuric and hydrochloric acid. The tableting behavior of obtained MCC samples and mixtures of MCC with ibuprofen was studied using a dynamic powder compaction analyzer. It was observed that some of the obtained MCC samples showed better flowing properties than commercially available Vivapur® PH101 and also very high values of tensile strength, solid fraction and elastic recovery. This can be linked with its good compaction behavior, but on the other hand it can cause problems with the disintegration of the tablets. In mixtures with ibuprofen, MCC samples showed lower values of tensile strength, while on the other hand elastic recovery did not seem to be much affected, still exhibiting very high values. According to the obtained results, it can be concluded that MCC obtained from the agricultural waste could have satisfactory properties for tablet preparation by the direct compression method. Further studies are needed to optimize process conditions in order to achieve better physicochemical characteristics, especially in terms of elastic recovery.
PB  - Elsevier B.V.
T2  - Saudi Pharmaceutical Journal
T1  - Tableting properties of microcrystalline cellulose obtained from wheat straw measured with a single punch bench top tablet press
VL  - 2
SP  - 710
EP  - 718
DO  - 10.1016/j.jsps.2020.04.013
ER  - 
@article{
author = "Krivokapić, Jovana and Ivanović, Jasna and Đuriš, Jelena and Medarević, Đorđe and Potpara, Zorica and Maksimović, Zoran and Ibrić, Svetlana",
year = "2020",
abstract = "The objective of this work was to study the relation between the manufacturing conditions of microcrystalline cellulose (MCC), its physicochemical properties and its tableting behavior. Two different preparation procedures were used to produce MCC from wheat straw, utilizing an acid hydrolysis method, either using only sulfuric acid or combination of sulfuric and hydrochloric acid. The tableting behavior of obtained MCC samples and mixtures of MCC with ibuprofen was studied using a dynamic powder compaction analyzer. It was observed that some of the obtained MCC samples showed better flowing properties than commercially available Vivapur® PH101 and also very high values of tensile strength, solid fraction and elastic recovery. This can be linked with its good compaction behavior, but on the other hand it can cause problems with the disintegration of the tablets. In mixtures with ibuprofen, MCC samples showed lower values of tensile strength, while on the other hand elastic recovery did not seem to be much affected, still exhibiting very high values. According to the obtained results, it can be concluded that MCC obtained from the agricultural waste could have satisfactory properties for tablet preparation by the direct compression method. Further studies are needed to optimize process conditions in order to achieve better physicochemical characteristics, especially in terms of elastic recovery.",
publisher = "Elsevier B.V.",
journal = "Saudi Pharmaceutical Journal",
title = "Tableting properties of microcrystalline cellulose obtained from wheat straw measured with a single punch bench top tablet press",
volume = "2",
pages = "710-718",
doi = "10.1016/j.jsps.2020.04.013"
}
Krivokapić, J., Ivanović, J., Đuriš, J., Medarević, Đ., Potpara, Z., Maksimović, Z.,& Ibrić, S.. (2020). Tableting properties of microcrystalline cellulose obtained from wheat straw measured with a single punch bench top tablet press. in Saudi Pharmaceutical Journal
Elsevier B.V.., 2, 710-718.
https://doi.org/10.1016/j.jsps.2020.04.013
Krivokapić J, Ivanović J, Đuriš J, Medarević Đ, Potpara Z, Maksimović Z, Ibrić S. Tableting properties of microcrystalline cellulose obtained from wheat straw measured with a single punch bench top tablet press. in Saudi Pharmaceutical Journal. 2020;2:710-718.
doi:10.1016/j.jsps.2020.04.013 .
Krivokapić, Jovana, Ivanović, Jasna, Đuriš, Jelena, Medarević, Đorđe, Potpara, Zorica, Maksimović, Zoran, Ibrić, Svetlana, "Tableting properties of microcrystalline cellulose obtained from wheat straw measured with a single punch bench top tablet press" in Saudi Pharmaceutical Journal, 2 (2020):710-718,
https://doi.org/10.1016/j.jsps.2020.04.013 . .

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