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dc.creatorKrivokapić, Jovana
dc.creatorIvanović, Jasna
dc.creatorĐuriš, Jelena
dc.creatorMedarević, Đorđe
dc.creatorPotpara, Zorica
dc.creatorMaksimović, Zoran
dc.creatorIbrić, Svetlana
dc.date.accessioned2020-06-23T08:59:12Z
dc.date.available2020-06-23T08:59:12Z
dc.date.issued2020
dc.identifier.issn1319-0164
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3621
dc.description.abstractThe objective of this work was to study the relation between the manufacturing conditions of microcrystalline cellulose (MCC), its physicochemical properties and its tableting behavior. Two different preparation procedures were used to produce MCC from wheat straw, utilizing an acid hydrolysis method, either using only sulfuric acid or combination of sulfuric and hydrochloric acid. The tableting behavior of obtained MCC samples and mixtures of MCC with ibuprofen was studied using a dynamic powder compaction analyzer. It was observed that some of the obtained MCC samples showed better flowing properties than commercially available Vivapur® PH101 and also very high values of tensile strength, solid fraction and elastic recovery. This can be linked with its good compaction behavior, but on the other hand it can cause problems with the disintegration of the tablets. In mixtures with ibuprofen, MCC samples showed lower values of tensile strength, while on the other hand elastic recovery did not seem to be much affected, still exhibiting very high values. According to the obtained results, it can be concluded that MCC obtained from the agricultural waste could have satisfactory properties for tablet preparation by the direct compression method. Further studies are needed to optimize process conditions in order to achieve better physicochemical characteristics, especially in terms of elastic recovery.en
dc.publisherElsevier B.V.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.rightsopenAccess
dc.sourceSaudi Pharmaceutical Journal
dc.subjectTableting properties
dc.subjectDirect compression
dc.subjectIbuprofen
dc.subjectMicrocrystalline cellulose
dc.subjectWheat straw
dc.titleTableting properties of microcrystalline cellulose obtained from wheat straw measured with a single punch bench top tablet pressen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractМаксимовић, Зоран; Кривокапић, Јована; Ивановић, Јасна; Ђуриш, Јелена; Медаревић, Ђорђе; Потпара, Зорица; Ибрић, Светлана;
dc.citation.volume2
dc.citation.spage710
dc.citation.epage718
dc.citation.rankM21~
dc.identifier.wos000540281200011
dc.identifier.doi10.1016/j.jsps.2020.04.013
dc.identifier.scopus2-s2.0-85084635770
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/7831/Tableting_properties_of_pub_2020.pdf
dc.type.versionpublishedVersion


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