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dc.creatorArdalić, Daniela
dc.creatorStefanović, Aleksandra
dc.creatorBanjac, Gorica
dc.creatorCabunac, Petar
dc.creatorMiljković, Milica
dc.creatorMandić-Marković, Vesna
dc.creatorStanimirović, Srđan
dc.creatorDamnjanović Pažin, Barbara
dc.creatorSpasić, Slavíca
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorKaradžov-Orlić, Nataša
dc.creatorMiković, Željko
dc.date.accessioned2020-07-02T07:28:33Z
dc.date.available2020-07-02T07:28:33Z
dc.date.issued2020
dc.identifier.issn0009-9120
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3626
dc.description.abstractObjectives: The goal of this study was to investigate metabolic changes in lipids and oxidative stress parameters in the first trimester of pregnancy with the more specific aim of estimating the significance and strength of researched parameters in the prediction of preeclampsia. Design and Methods. The study included 87 high-risk pregnant (HRG) female subjects, 14 with developed preeclampsia (PEC) and 43 healthy pregnant female subjects matched for gestational age (CG). Thiobarbituric acid-reactive substances (TBARS) concentration, lipid hydroperoxides (LOOH), pro-oxidant antioxidant balance (PAB) and total oxidative status (TOS) were measured as oxidative stress markers, while total antioxidant capacity (TAC) was measured as an antioxidative defense parameter. The Atherogenic Index of Plasma (AIP) was calculated as the base 10 logarithm of the ratio of the plasma concentration of triglycerides (TG) to the plasma concentration of highdensity lipoprotein cholesterol (HDL-C), with each concentration expressed in mmol/L. Results: The results have shown that lipid indices, especially AIP, were significantly higher in the first trimester of HRG (p < 0.001) and PEC (p < 0.001). Oxidative stress parameters were significantlly higher, while TAC was significantly lower in HRG vs. CG [0.7 ± 0.15 vs 1.1 ± 0.16; (p < 0.001)] and in PEC [0.6 ± 0.12 vs 1.1 ± 0.16; (p < 0.001)] vs. CG. Also, in the HRG, results have shown an independent association of AIP with the preeclampsia development (p < 0.05), while placental growth factor did not show the expected level of significance (p = 0.648). Analysis of the Receiver Operating Characteristics (ROC) curves indicated that certain parameters included in the research model have very good diagnostic accuracy for preeclampsia (AUC = 0.856). Conclusions: AIP is associated with high-risk pregnancies. Furthermore, our results firmly underscored AIP as a potential marker for preeclampsia prediction.en
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Biochemistry
dc.subjectPreeclampsia
dc.subjectAtherogenic index of plasma
dc.subjectHigh-risk pregnancies
dc.titleLipid profile and lipid oxidative modification parameters in the first trimester of high- risk pregnancies - possibilities for preeclampsia predictionen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМиковић, Жељко; Цабунац, П.; Станимировић, С.; Дамњановић Пажин, Барбара; Спасић, Славíца; Aрдалић, Даниела; Стефановић, Aлександра; Бањац, Горица; Миљковић, Милица; Мандић-Марковић, Весна; Спасојевић-Калимановска, Весна; Караджов-Орлић, Наташа;
dc.citation.volume81
dc.citation.spage34
dc.citation.epage40
dc.citation.rankM22
dc.identifier.wos000541483300007
dc.identifier.doi10.1016/j.clinbiochem.2020.05.003
dc.identifier.scopus2-s2.0-85086793201
dc.type.versionpublishedVersion


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