Prevention and treatment of non-communicable diseases (NCDs), including cardiovascular disease, diabetes, obesity, cancer, Alzheimer's and Parkinson's disease, arthritis, non-alcoholic fatty liver disease and various infectious diseases; lately most notably COVID-19 have been in the front line of research worldwide. Although targeting different organs, these pathologies have common biochemical impairments – redox disparity and, prominently, dysregulation of the inflammatory pathways. Research data have shown that diet components like polyphenols, poly-unsaturated fatty acids (PUFAs), fibres as well as lifestyle (fasting, physical exercise) are important factors influencing signalling pathways with a significant potential to improve metabolic homeostasis and immune cells' functions. In the present manuscript we have reviewed scientific data from recent publications regarding the beneficial cellular and molecular effects induced by dietary plant products, mainly polyphenolic compounds an...d PUFAs, and summarize the clinical outcomes expected from these types of interventions, in a search for effective long-term approaches to improve the immune system response.
TY - JOUR
AU - Margină, Denisa
AU - Ungurianu, Anca
AU - Purdel, Carmaen
AU - Nițulescu, George Mihai
AU - Tsoukalas, Dimitris
AU - Sarandi, Evangelia
AU - Thanasoula, Maria
AU - Burykina, Tatyana
AU - Tekos, Fotis
AU - Buha, Aleksandra
AU - Nikitović, Dragana
AU - Kouretas, Demetrios
AU - Tsatsakis, Aristidis Michael
PY - 2020
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3630
AB - Prevention and treatment of non-communicable diseases (NCDs), including cardiovascular disease, diabetes, obesity, cancer, Alzheimer's and Parkinson's disease, arthritis, non-alcoholic fatty liver disease and various infectious diseases; lately most notably COVID-19 have been in the front line of research worldwide. Although targeting different organs, these pathologies have common biochemical impairments – redox disparity and, prominently, dysregulation of the inflammatory pathways. Research data have shown that diet components like polyphenols, poly-unsaturated fatty acids (PUFAs), fibres as well as lifestyle (fasting, physical exercise) are important factors influencing signalling pathways with a significant potential to improve metabolic homeostasis and immune cells' functions. In the present manuscript we have reviewed scientific data from recent publications regarding the beneficial cellular and molecular effects induced by dietary plant products, mainly polyphenolic compounds and PUFAs, and summarize the clinical outcomes expected from these types of interventions, in a search for effective long-term approaches to improve the immune system response.
PB - Elsevier Ltd
T2 - Food and Chemical Toxicology
T1 - Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease
VL - 143
DO - 10.1016/j.fct.2020.111558
ER -
@article{
author = "Margină, Denisa and Ungurianu, Anca and Purdel, Carmaen and Nițulescu, George Mihai and Tsoukalas, Dimitris and Sarandi, Evangelia and Thanasoula, Maria and Burykina, Tatyana and Tekos, Fotis and Buha, Aleksandra and Nikitović, Dragana and Kouretas, Demetrios and Tsatsakis, Aristidis Michael",
year = "2020",
abstract = "Prevention and treatment of non-communicable diseases (NCDs), including cardiovascular disease, diabetes, obesity, cancer, Alzheimer's and Parkinson's disease, arthritis, non-alcoholic fatty liver disease and various infectious diseases; lately most notably COVID-19 have been in the front line of research worldwide. Although targeting different organs, these pathologies have common biochemical impairments – redox disparity and, prominently, dysregulation of the inflammatory pathways. Research data have shown that diet components like polyphenols, poly-unsaturated fatty acids (PUFAs), fibres as well as lifestyle (fasting, physical exercise) are important factors influencing signalling pathways with a significant potential to improve metabolic homeostasis and immune cells' functions. In the present manuscript we have reviewed scientific data from recent publications regarding the beneficial cellular and molecular effects induced by dietary plant products, mainly polyphenolic compounds and PUFAs, and summarize the clinical outcomes expected from these types of interventions, in a search for effective long-term approaches to improve the immune system response.",
publisher = "Elsevier Ltd",
journal = "Food and Chemical Toxicology",
title = "Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease",
volume = "143",
doi = "10.1016/j.fct.2020.111558"
}
Margină, D., Ungurianu, A., Purdel, C., Nițulescu, G. M., Tsoukalas, D., Sarandi, E., Thanasoula, M., Burykina, T., Tekos, F., Buha, A., Nikitović, D., Kouretas, D.,& Tsatsakis, A. M.. (2020). Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease. in Food and Chemical Toxicology
Elsevier Ltd., 143.
https://doi.org/10.1016/j.fct.2020.111558
Margină D, Ungurianu A, Purdel C, Nițulescu GM, Tsoukalas D, Sarandi E, Thanasoula M, Burykina T, Tekos F, Buha A, Nikitović D, Kouretas D, Tsatsakis AM. Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease. in Food and Chemical Toxicology. 2020;143.
doi:10.1016/j.fct.2020.111558 .
Margină, Denisa, Ungurianu, Anca, Purdel, Carmaen, Nițulescu, George Mihai, Tsoukalas, Dimitris, Sarandi, Evangelia, Thanasoula, Maria, Burykina, Tatyana, Tekos, Fotis, Buha, Aleksandra, Nikitović, Dragana, Kouretas, Demetrios, Tsatsakis, Aristidis Michael, "Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease" in Food and Chemical Toxicology, 143 (2020),
https://doi.org/10.1016/j.fct.2020.111558 . .
