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Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease

Само за регистроване кориснике
2020
Аутори
Margină, Denisa
Ungurianu, Anca
Purdel, Carmaen
Nițulescu, George Mihai
Tsoukalas, Dimitris
Sarandi, Evangelia
Thanasoula, Maria
Burykina, Tatyana
Tekos, Fotis
Buha, Aleksandra
Nikitović, Dragana
Kouretas, Demetrios
Tsatsakis, Aristidis Michael
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документу
Апстракт
Prevention and treatment of non-communicable diseases (NCDs), including cardiovascular disease, diabetes, obesity, cancer, Alzheimer's and Parkinson's disease, arthritis, non-alcoholic fatty liver disease and various infectious diseases; lately most notably COVID-19 have been in the front line of research worldwide. Although targeting different organs, these pathologies have common biochemical impairments – redox disparity and, prominently, dysregulation of the inflammatory pathways. Research data have shown that diet components like polyphenols, poly-unsaturated fatty acids (PUFAs), fibres as well as lifestyle (fasting, physical exercise) are important factors influencing signalling pathways with a significant potential to improve metabolic homeostasis and immune cells' functions. In the present manuscript we have reviewed scientific data from recent publications regarding the beneficial cellular and molecular effects induced by dietary plant products, mainly polyphenolic compounds an...d PUFAs, and summarize the clinical outcomes expected from these types of interventions, in a search for effective long-term approaches to improve the immune system response.

Кључне речи:
Inflammation / Polyphenols / Nutraceuticals / Polyunsaturated fatty acids
Извор:
Food and Chemical Toxicology, 2020, 143
Издавач:
  • Elsevier Ltd

DOI: 10.1016/j.fct.2020.111558

ISSN: 0278-6915

WoS: 000562731900037

Scopus: 2-s2.0-85087483525
[ Google Scholar ]
3
1
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3630
Колекције
  • Radovi istraživača / Researchers’ publications
Институција
Pharmacy

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