Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease
Samo za registrovane korisnike
2020
Autori
Margină, DenisaUngurianu, Anca
Purdel, Carmaen
Nițulescu, George Mihai
Tsoukalas, Dimitris
Sarandi, Evangelia
Thanasoula, Maria
Burykina, Tatyana
Tekos, Fotis
Buha, Aleksandra

Nikitović, Dragana
Kouretas, Demetrios
Tsatsakis, Aristidis Michael
Članak u časopisu (Objavljena verzija)

Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Prevention and treatment of non-communicable diseases (NCDs), including cardiovascular disease, diabetes, obesity, cancer, Alzheimer's and Parkinson's disease, arthritis, non-alcoholic fatty liver disease and various infectious diseases; lately most notably COVID-19 have been in the front line of research worldwide. Although targeting different organs, these pathologies have common biochemical impairments – redox disparity and, prominently, dysregulation of the inflammatory pathways. Research data have shown that diet components like polyphenols, poly-unsaturated fatty acids (PUFAs), fibres as well as lifestyle (fasting, physical exercise) are important factors influencing signalling pathways with a significant potential to improve metabolic homeostasis and immune cells' functions. In the present manuscript we have reviewed scientific data from recent publications regarding the beneficial cellular and molecular effects induced by dietary plant products, mainly polyphenolic compounds an...d PUFAs, and summarize the clinical outcomes expected from these types of interventions, in a search for effective long-term approaches to improve the immune system response.
Ključne reči:
Inflammation / Polyphenols / Nutraceuticals / Polyunsaturated fatty acidsIzvor:
Food and Chemical Toxicology, 2020, 143Izdavač:
- Elsevier Ltd
DOI: 10.1016/j.fct.2020.111558
ISSN: 0278-6915