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dc.creatorMargină, Denisa
dc.creatorUngurianu, Anca
dc.creatorPurdel, Carmaen
dc.creatorNițulescu, George Mihai
dc.creatorTsoukalas, Dimitris
dc.creatorSarandi, Evangelia
dc.creatorThanasoula, Maria
dc.creatorBurykina, Tatyana
dc.creatorTekos, Fotis
dc.creatorBuha, Aleksandra
dc.creatorNikitović, Dragana
dc.creatorKouretas, Demetrios
dc.creatorTsatsakis, Aristidis Michael
dc.date.accessioned2020-07-15T07:11:13Z
dc.date.available2020-07-15T07:11:13Z
dc.date.issued2020
dc.identifier.issn0278-6915
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3630
dc.description.abstractPrevention and treatment of non-communicable diseases (NCDs), including cardiovascular disease, diabetes, obesity, cancer, Alzheimer's and Parkinson's disease, arthritis, non-alcoholic fatty liver disease and various infectious diseases; lately most notably COVID-19 have been in the front line of research worldwide. Although targeting different organs, these pathologies have common biochemical impairments – redox disparity and, prominently, dysregulation of the inflammatory pathways. Research data have shown that diet components like polyphenols, poly-unsaturated fatty acids (PUFAs), fibres as well as lifestyle (fasting, physical exercise) are important factors influencing signalling pathways with a significant potential to improve metabolic homeostasis and immune cells' functions. In the present manuscript we have reviewed scientific data from recent publications regarding the beneficial cellular and molecular effects induced by dietary plant products, mainly polyphenolic compounds and PUFAs, and summarize the clinical outcomes expected from these types of interventions, in a search for effective long-term approaches to improve the immune system response.en
dc.publisherElsevier Ltd
dc.rightsrestrictedAccess
dc.sourceFood and Chemical Toxicology
dc.subjectInflammation
dc.subjectPolyphenols
dc.subjectNutraceuticals
dc.subjectPolyunsaturated fatty acids
dc.titleAnalysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and diseaseen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПурдел, Цармаен; Ниțулесцу, Георге Михаи; Тсоукалас, Д.; Саранди, Евангелиа; Тханасоула, Мариа; Никитовиц, Драгана; Бурyкина, Татyана; Буха, Aлександра; Коуретас, Деметриос; Маргинă, Дениса; Унгуриану, Aнца; Текос, Фотис; Тсатсакис, Aристидис Мицхаел;
dc.citation.volume143
dc.citation.rankM21~
dc.identifier.wos000562731900037
dc.identifier.doi10.1016/j.fct.2020.111558
dc.identifier.scopus2-s2.0-85087483525
dc.type.versionpublishedVersion


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