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Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats

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2020
Authors
Baralić, Katarina
Živančević, Katarina
Javorac, Dragana
Buha-Đorđević, Aleksandra
Anđelković, Milena
Jorgovanović, Dragica
Antonijević-Miljaković, Evica
Ćurčić, Marijana
Bulat, Zorica
Antonijević, Biljana
Đukić-Ćosić, Danijela
Article (Published version)
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Abstract
Phthalates and bisphenol A, to which people are mainly exposed through food, interfere with the body's endocrine system, along with various other toxic effects. Literature data suggest that probiotic cultures might be able to decrease the adverse effects of toxic substances by various mechanisms. The aim of this study was to investigate if treatment with multi-strained probiotic could reduce the toxicity of phthalates and bisphenol A mixture in Wistar rats. Animals were divided into four experimental groups (n = 6): (1) Control (corn oil); (2) P (probiotic (8.78 * 108 CFU/kg/day): Saccharomyces boulardii + Lactobacillus rhamnosus + Lactobacillus planarum LP 6595+ Lactobacillus planarum HEAL9); (3) MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA); (4) MIX + P. Animals were euthanized after 28 days of daily oral gavage treatment; blood and organs were collected for further analysis. Probiotic reduced systemic inflammation and had protective effects on liver, ki...dneys, spleen, lipid status and serum glucose level. It almost completely annulled the changes in biochemical, hematological and hormonal parameters and mitigated changes in relative liver size, food consumption and organ histology. These results suggest considering multi-strained probiotics as a dietary therapeutic strategy against toxicity of the investigated mixture.

Keywords:
Bisphenol A / Mixture toxicity / Phthalates / Probiotic / Protective effects
Source:
Food and Chemical Toxicology, 2020, 143
Publisher:
  • Elsevier Ltd
Projects:
  • Improvement and development of hygienic and technological procedures in production of animal originating foodstuffs with the aim of producing high-quality and safe products competetive on the global market (RS-46009)
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200161 (University of Belgrade, Faculty of Pharmacy) (RS-200161)

DOI: 10.1016/j.fct.2020.111540

ISSN: 0278-6915

WoS: 000562731900026

Scopus: 2-s2.0-85087784147
[ Google Scholar ]
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3634
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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