Phthalates and bisphenol A, to which people are mainly exposed through food, interfere with the body's endocrine system, along with various other toxic effects. Literature data suggest that probiotic cultures might be able to decrease the adverse effects of toxic substances by various mechanisms. The aim of this study was to investigate if treatment with multi-strained probiotic could reduce the toxicity of phthalates and bisphenol A mixture in Wistar rats. Animals were divided into four experimental groups (n = 6): (1) Control (corn oil); (2) P (probiotic (8.78 * 108 CFU/kg/day): Saccharomyces boulardii + Lactobacillus rhamnosus + Lactobacillus planarum LP 6595+ Lactobacillus planarum HEAL9); (3) MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA); (4) MIX + P. Animals were euthanized after 28 days of daily oral gavage treatment; blood and organs were collected for further analysis. Probiotic reduced systemic inflammation and had protective effects on liver, ki...dneys, spleen, lipid status and serum glucose level. It almost completely annulled the changes in biochemical, hematological and hormonal parameters and mitigated changes in relative liver size, food consumption and organ histology. These results suggest considering multi-strained probiotics as a dietary therapeutic strategy against toxicity of the investigated mixture.
TY - JOUR
AU - Baralić, Katarina
AU - Živančević, Katarina
AU - Javorac, Dragana
AU - Buha-Đorđević, Aleksandra
AU - Anđelković, Milena
AU - Jorgovanović, Dragica
AU - Antonijević-Miljaković, Evica
AU - Ćurčić, Marijana
AU - Bulat, Zorica
AU - Antonijević, Biljana
AU - Đukić-Ćosić, Danijela
PY - 2020
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/3634
AB - Phthalates and bisphenol A, to which people are mainly exposed through food, interfere with the body's endocrine system, along with various other toxic effects. Literature data suggest that probiotic cultures might be able to decrease the adverse effects of toxic substances by various mechanisms. The aim of this study was to investigate if treatment with multi-strained probiotic could reduce the toxicity of phthalates and bisphenol A mixture in Wistar rats. Animals were divided into four experimental groups (n = 6): (1) Control (corn oil); (2) P (probiotic (8.78 * 108 CFU/kg/day): Saccharomyces boulardii + Lactobacillus rhamnosus + Lactobacillus planarum LP 6595+ Lactobacillus planarum HEAL9); (3) MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA); (4) MIX + P. Animals were euthanized after 28 days of daily oral gavage treatment; blood and organs were collected for further analysis. Probiotic reduced systemic inflammation and had protective effects on liver, kidneys, spleen, lipid status and serum glucose level. It almost completely annulled the changes in biochemical, hematological and hormonal parameters and mitigated changes in relative liver size, food consumption and organ histology. These results suggest considering multi-strained probiotics as a dietary therapeutic strategy against toxicity of the investigated mixture.
PB - Elsevier Ltd
T2 - Food and Chemical Toxicology
T1 - Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats
VL - 143
DO - 10.1016/j.fct.2020.111540
ER -
@article{
author = "Baralić, Katarina and Živančević, Katarina and Javorac, Dragana and Buha-Đorđević, Aleksandra and Anđelković, Milena and Jorgovanović, Dragica and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2020",
abstract = "Phthalates and bisphenol A, to which people are mainly exposed through food, interfere with the body's endocrine system, along with various other toxic effects. Literature data suggest that probiotic cultures might be able to decrease the adverse effects of toxic substances by various mechanisms. The aim of this study was to investigate if treatment with multi-strained probiotic could reduce the toxicity of phthalates and bisphenol A mixture in Wistar rats. Animals were divided into four experimental groups (n = 6): (1) Control (corn oil); (2) P (probiotic (8.78 * 108 CFU/kg/day): Saccharomyces boulardii + Lactobacillus rhamnosus + Lactobacillus planarum LP 6595+ Lactobacillus planarum HEAL9); (3) MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA); (4) MIX + P. Animals were euthanized after 28 days of daily oral gavage treatment; blood and organs were collected for further analysis. Probiotic reduced systemic inflammation and had protective effects on liver, kidneys, spleen, lipid status and serum glucose level. It almost completely annulled the changes in biochemical, hematological and hormonal parameters and mitigated changes in relative liver size, food consumption and organ histology. These results suggest considering multi-strained probiotics as a dietary therapeutic strategy against toxicity of the investigated mixture.",
publisher = "Elsevier Ltd",
journal = "Food and Chemical Toxicology",
title = "Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats",
volume = "143",
doi = "10.1016/j.fct.2020.111540"
}
Baralić, K., Živančević, K., Javorac, D., Buha-Đorđević, A., Anđelković, M., Jorgovanović, D., Antonijević-Miljaković, E., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2020). Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats. in Food and Chemical Toxicology
Elsevier Ltd., 143.
https://doi.org/10.1016/j.fct.2020.111540
Baralić K, Živančević K, Javorac D, Buha-Đorđević A, Anđelković M, Jorgovanović D, Antonijević-Miljaković E, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats. in Food and Chemical Toxicology. 2020;143.
doi:10.1016/j.fct.2020.111540 .
Baralić, Katarina, Živančević, Katarina, Javorac, Dragana, Buha-Đorđević, Aleksandra, Anđelković, Milena, Jorgovanović, Dragica, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats" in Food and Chemical Toxicology, 143 (2020),
https://doi.org/10.1016/j.fct.2020.111540 . .
