Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats
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2020
Authors
Baralić, Katarina![](/themes/MirageFarFaR/images/orcid.png)
Živančević, Katarina
![](/themes/MirageFarFaR/images/orcid.png)
Javorac, Dragana
![](/themes/MirageFarFaR/images/orcid.png)
Buha-Đorđević, Aleksandra
![](/themes/MirageFarFaR/images/orcid.png)
Anđelković, Milena
![](/themes/MirageFarFaR/images/orcid.png)
Jorgovanović, Dragica
![](/themes/MirageFarFaR/images/orcid.png)
Antonijević-Miljaković, Evica
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Ćurčić, Marijana
![](/themes/MirageFarFaR/images/orcid.png)
Bulat, Zorica
![](/themes/MirageFarFaR/images/orcid.png)
Antonijević, Biljana
![](/themes/MirageFarFaR/images/orcid.png)
Đukić-Ćosić, Danijela
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Article (Published version)
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Show full item recordAbstract
Phthalates and bisphenol A, to which people are mainly exposed through food, interfere with the body's endocrine system, along with various other toxic effects. Literature data suggest that probiotic cultures might be able to decrease the adverse effects of toxic substances by various mechanisms. The aim of this study was to investigate if treatment with multi-strained probiotic could reduce the toxicity of phthalates and bisphenol A mixture in Wistar rats. Animals were divided into four experimental groups (n = 6): (1) Control (corn oil); (2) P (probiotic (8.78 * 108 CFU/kg/day): Saccharomyces boulardii + Lactobacillus rhamnosus + Lactobacillus planarum LP 6595+ Lactobacillus planarum HEAL9); (3) MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA); (4) MIX + P. Animals were euthanized after 28 days of daily oral gavage treatment; blood and organs were collected for further analysis. Probiotic reduced systemic inflammation and had protective effects on liver, ki...dneys, spleen, lipid status and serum glucose level. It almost completely annulled the changes in biochemical, hematological and hormonal parameters and mitigated changes in relative liver size, food consumption and organ histology. These results suggest considering multi-strained probiotics as a dietary therapeutic strategy against toxicity of the investigated mixture.
Keywords:
Bisphenol A / Mixture toxicity / Phthalates / Probiotic / Protective effectsSource:
Food and Chemical Toxicology, 2020, 143Publisher:
- Elsevier Ltd
Funding / projects:
- Improvement and development of hygienic and technological procedures in production of animal originating foodstuffs with the aim of producing high-quality and safe products competetive on the global market (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46009)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200161 (University of Belgrade, Faculty of Pharmacy) (RS-MESTD-inst-2020-200161)
DOI: 10.1016/j.fct.2020.111540
ISSN: 0278-6915
WoS: 000562731900026
Scopus: 2-s2.0-85087784147
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Institution/Community
PharmacyTY - JOUR AU - Baralić, Katarina AU - Živančević, Katarina AU - Javorac, Dragana AU - Buha-Đorđević, Aleksandra AU - Anđelković, Milena AU - Jorgovanović, Dragica AU - Antonijević-Miljaković, Evica AU - Ćurčić, Marijana AU - Bulat, Zorica AU - Antonijević, Biljana AU - Đukić-Ćosić, Danijela PY - 2020 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3634 AB - Phthalates and bisphenol A, to which people are mainly exposed through food, interfere with the body's endocrine system, along with various other toxic effects. Literature data suggest that probiotic cultures might be able to decrease the adverse effects of toxic substances by various mechanisms. The aim of this study was to investigate if treatment with multi-strained probiotic could reduce the toxicity of phthalates and bisphenol A mixture in Wistar rats. Animals were divided into four experimental groups (n = 6): (1) Control (corn oil); (2) P (probiotic (8.78 * 108 CFU/kg/day): Saccharomyces boulardii + Lactobacillus rhamnosus + Lactobacillus planarum LP 6595+ Lactobacillus planarum HEAL9); (3) MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA); (4) MIX + P. Animals were euthanized after 28 days of daily oral gavage treatment; blood and organs were collected for further analysis. Probiotic reduced systemic inflammation and had protective effects on liver, kidneys, spleen, lipid status and serum glucose level. It almost completely annulled the changes in biochemical, hematological and hormonal parameters and mitigated changes in relative liver size, food consumption and organ histology. These results suggest considering multi-strained probiotics as a dietary therapeutic strategy against toxicity of the investigated mixture. PB - Elsevier Ltd T2 - Food and Chemical Toxicology T1 - Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats VL - 143 DO - 10.1016/j.fct.2020.111540 ER -
@article{ author = "Baralić, Katarina and Živančević, Katarina and Javorac, Dragana and Buha-Đorđević, Aleksandra and Anđelković, Milena and Jorgovanović, Dragica and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela", year = "2020", abstract = "Phthalates and bisphenol A, to which people are mainly exposed through food, interfere with the body's endocrine system, along with various other toxic effects. Literature data suggest that probiotic cultures might be able to decrease the adverse effects of toxic substances by various mechanisms. The aim of this study was to investigate if treatment with multi-strained probiotic could reduce the toxicity of phthalates and bisphenol A mixture in Wistar rats. Animals were divided into four experimental groups (n = 6): (1) Control (corn oil); (2) P (probiotic (8.78 * 108 CFU/kg/day): Saccharomyces boulardii + Lactobacillus rhamnosus + Lactobacillus planarum LP 6595+ Lactobacillus planarum HEAL9); (3) MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA); (4) MIX + P. Animals were euthanized after 28 days of daily oral gavage treatment; blood and organs were collected for further analysis. Probiotic reduced systemic inflammation and had protective effects on liver, kidneys, spleen, lipid status and serum glucose level. It almost completely annulled the changes in biochemical, hematological and hormonal parameters and mitigated changes in relative liver size, food consumption and organ histology. These results suggest considering multi-strained probiotics as a dietary therapeutic strategy against toxicity of the investigated mixture.", publisher = "Elsevier Ltd", journal = "Food and Chemical Toxicology", title = "Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats", volume = "143", doi = "10.1016/j.fct.2020.111540" }
Baralić, K., Živančević, K., Javorac, D., Buha-Đorđević, A., Anđelković, M., Jorgovanović, D., Antonijević-Miljaković, E., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2020). Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats. in Food and Chemical Toxicology Elsevier Ltd., 143. https://doi.org/10.1016/j.fct.2020.111540
Baralić K, Živančević K, Javorac D, Buha-Đorđević A, Anđelković M, Jorgovanović D, Antonijević-Miljaković E, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats. in Food and Chemical Toxicology. 2020;143. doi:10.1016/j.fct.2020.111540 .
Baralić, Katarina, Živančević, Katarina, Javorac, Dragana, Buha-Đorđević, Aleksandra, Anđelković, Milena, Jorgovanović, Dragica, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats" in Food and Chemical Toxicology, 143 (2020), https://doi.org/10.1016/j.fct.2020.111540 . .