Show simple item record

dc.creatorBaralić, Katarina
dc.creatorŽivančević, Katarina
dc.creatorJavorac, Dragana
dc.creatorBuha-Đorđević, Aleksandra
dc.creatorAnđelković, Milena
dc.creatorJorgovanović, Dragica
dc.creatorAntonijević-Miljaković, Evica
dc.creatorĆurčić, Marijana
dc.creatorBulat, Zorica
dc.creatorAntonijević, Biljana
dc.creatorĐukić-Ćosić, Danijela
dc.date.accessioned2020-07-23T07:37:16Z
dc.date.available2020-07-23T07:37:16Z
dc.date.issued2020
dc.identifier.issn0278-6915
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3634
dc.description.abstractPhthalates and bisphenol A, to which people are mainly exposed through food, interfere with the body's endocrine system, along with various other toxic effects. Literature data suggest that probiotic cultures might be able to decrease the adverse effects of toxic substances by various mechanisms. The aim of this study was to investigate if treatment with multi-strained probiotic could reduce the toxicity of phthalates and bisphenol A mixture in Wistar rats. Animals were divided into four experimental groups (n = 6): (1) Control (corn oil); (2) P (probiotic (8.78 * 108 CFU/kg/day): Saccharomyces boulardii + Lactobacillus rhamnosus + Lactobacillus planarum LP 6595+ Lactobacillus planarum HEAL9); (3) MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA); (4) MIX + P. Animals were euthanized after 28 days of daily oral gavage treatment; blood and organs were collected for further analysis. Probiotic reduced systemic inflammation and had protective effects on liver, kidneys, spleen, lipid status and serum glucose level. It almost completely annulled the changes in biochemical, hematological and hormonal parameters and mitigated changes in relative liver size, food consumption and organ histology. These results suggest considering multi-strained probiotics as a dietary therapeutic strategy against toxicity of the investigated mixture.en
dc.publisherElsevier Ltd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46009/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.rightsrestrictedAccess
dc.sourceFood and Chemical Toxicology
dc.subjectBisphenol A
dc.subjectMixture toxicity
dc.subjectPhthalates
dc.subjectProbiotic
dc.subjectProtective effects
dc.titleMulti-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar ratsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAнтонијевић, Биљана; Aнтонијевић Миљаковић, Евица; Ђукић-Ћосић, Данијела; Јаворац, Драгана; Aнђелковић, Милена; Ћурчић, Маријана; Јорговановић, Драгица; Булат, Зорица; Буха-Ђорђевић, Aлександра; Баралић, Катарина; Живанчевић, Катарина;
dc.citation.volume143
dc.citation.rankM21~
dc.identifier.wos000562731900026
dc.identifier.doi10.1016/j.fct.2020.111540
dc.identifier.scopus2-s2.0-85087784147
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record