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dc.creatorMilutinović, Violeta
dc.creatorPecikoza, Uroš
dc.creatorTomić, Maja
dc.creatorStepanović-Petrović, Radica
dc.creatorNiketić, Marjan
dc.creatorUšjak, Ljuboš
dc.creatorPetrović, Silvana
dc.date.accessioned2020-08-17T07:51:18Z
dc.date.available2020-08-17T07:51:18Z
dc.date.issued2020
dc.identifier.issn1478-6419
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3641
dc.description.abstractPresent study investigated triterpene profile, antihyperalgesic and antiedematous activities of Hieracium scheppigianum flowering aerial parts dichloromethane extract (SCH), and antihyperalgesic and antiedematous activities of previously chemically characterised polyphenol-rich H. glabratum and H. calophyllum flowering aerial parts methanol extracts (GLA and CAL, respectively). α- and β-Amyrin and their acetates, and lupeol acetate were identified and quantified in SCH by GC-FID and GC-MS. In carrageenan-induced localised inflammation model in rats, SCH and GLA (50–200 mg/kg, p.o.) produced significant and dose-dependent antihyperalgesic effect of 26.9%–56.2% (ED50=163.0 ± 26.5 mg/kg) and 25.3%–51.6% (ED50=211.6 ± 70.6 mg/kg), respectively, and CAL (200 mg/kg, p.o.) exhibited effect of 38.1%. Extracts did not significantly reduce paw edema. SCH and GLA, which demonstrated higher (over 50%) antihyperalgesic efficacy, were tested in a rotarod test (200 mg/kg, p.o.) and no alteration of motor coordination was observed. Also, acute administration of SCH and GLA in mice (2000 mg/kg, p.o.) caused neither mortality nor toxicity.en
dc.language.isoensr
dc.publisherTaylor & Francis Ltdsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175045/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173021/RS//sr
dc.rightsrestrictedAccesssr
dc.sourceNatural Product Researchsr
dc.subjectHieraciumsr
dc.subjecttriterpene/polyphenol rich extractssr
dc.subjectcarrageenan-induced inflammationsr
dc.subjectantihyperalgesic activitysr
dc.subjectantiedematous activitysr
dc.subjectacute toxicity screeningsr
dc.titleInvestigation of antihyperalgesic and antiedematous activities of three Hieracium speciesen
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractСтепановић-Петровић, Радица; Ушјак, Љубош; Петровић, Силвана; Никетић, Марјан; Милутиновић, Виолета; Пецикоза, Урош; Томић, Маја A.;
dc.citation.rankM22~
dc.identifier.wos000538733200001
dc.identifier.doi10.1080/14786419.2020.1768086
dc.identifier.pmid32441121
dc.identifier.scopus2-s2.0-85085613046
dc.type.versionpublishedVersionsr


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