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Investigation of antihyperalgesic and antiedematous activities of three Hieracium species
dc.creator | Milutinović, Violeta | |
dc.creator | Pecikoza, Uroš | |
dc.creator | Tomić, Maja | |
dc.creator | Stepanović-Petrović, Radica | |
dc.creator | Niketić, Marjan | |
dc.creator | Ušjak, Ljuboš | |
dc.creator | Petrović, Silvana | |
dc.date.accessioned | 2020-08-17T07:51:18Z | |
dc.date.available | 2020-08-17T07:51:18Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1478-6419 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3641 | |
dc.description.abstract | Present study investigated triterpene profile, antihyperalgesic and antiedematous activities of Hieracium scheppigianum flowering aerial parts dichloromethane extract (SCH), and antihyperalgesic and antiedematous activities of previously chemically characterised polyphenol-rich H. glabratum and H. calophyllum flowering aerial parts methanol extracts (GLA and CAL, respectively). α- and β-Amyrin and their acetates, and lupeol acetate were identified and quantified in SCH by GC-FID and GC-MS. In carrageenan-induced localised inflammation model in rats, SCH and GLA (50–200 mg/kg, p.o.) produced significant and dose-dependent antihyperalgesic effect of 26.9%–56.2% (ED50=163.0 ± 26.5 mg/kg) and 25.3%–51.6% (ED50=211.6 ± 70.6 mg/kg), respectively, and CAL (200 mg/kg, p.o.) exhibited effect of 38.1%. Extracts did not significantly reduce paw edema. SCH and GLA, which demonstrated higher (over 50%) antihyperalgesic efficacy, were tested in a rotarod test (200 mg/kg, p.o.) and no alteration of motor coordination was observed. Also, acute administration of SCH and GLA in mice (2000 mg/kg, p.o.) caused neither mortality nor toxicity. | en |
dc.language.iso | en | sr |
dc.publisher | Taylor & Francis Ltd | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175045/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173021/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Natural Product Research | sr |
dc.subject | Hieracium | sr |
dc.subject | triterpene/polyphenol rich extracts | sr |
dc.subject | carrageenan-induced inflammation | sr |
dc.subject | antihyperalgesic activity | sr |
dc.subject | antiedematous activity | sr |
dc.subject | acute toxicity screening | sr |
dc.title | Investigation of antihyperalgesic and antiedematous activities of three Hieracium species | en |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Степановић-Петровић, Радица; Ушјак, Љубош; Петровић, Силвана; Никетић, Марјан; Милутиновић, Виолета; Пецикоза, Урош; Томић, Маја A.; | |
dc.citation.volume | 35 | |
dc.citation.issue | 23 | |
dc.citation.spage | 5384 | |
dc.citation.epage | 5388 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000538733200001 | |
dc.identifier.doi | 10.1080/14786419.2020.1768086 | |
dc.identifier.pmid | 32441121 | |
dc.identifier.scopus | 2-s2.0-85085613046 | |
dc.type.version | publishedVersion | sr |