rcub.pharmacy.logo
rcub.pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   IBISS RADaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   IBISS RADaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Relevance and evaluation of the benchmark dose in toxicology

Značaj i procena benchmark doze u toksikologiji

Thumbnail
2020
Relevance_and_evaluation_pub_2020.pdf (646.6Kb)
Authors
Baralić, Katarina
Javorac, Dragana
Antonijević, Evica
Buha-Đorđević, Aleksandra
Ćurčić, Marijana
Đukić-Ćosić, Danijela
Bulat, Zorica
Antonijević, Biljana
Article (Published version)
Metadata
Show full item record
Abstract
This paper aims to present the importance of the benchmark dose (BMD) as a point of departure (the lowest dose or concentration in the experiment that deviates from the response that differs from the normal response) in toxicological risk assessment, as well as to present commonly used software for its calculation (BMDS and PROAST). Benchmark dose is defined as a statistical lower confidence limit of a dose that results in a small change in effect (5-10%) in comparison with the control value. The BMD approach is considered a substitution for the NOAEL approach, which uses the highest observed no-effect level (NOAEL) to obtain the reference dose. The BMD approach is a methodically more forward-thinking technique than the NOAEL approach because it has statistical power and provides a wide range of dose-response relationships and allows the determination of their uncertainty and variability. Moreover, the BMD approach contributes to the reduction of experimental animals i...n toxicity studies. Therefore, the European Food Safety Authority (EFSA) recommends the use of BMDL10values for quantal and BMDL05for continuous data.

Cilj ovog rada je da predstavi značaj granične benchmark doze (engl. benchmark dose, BMD) kao polaznog doznog nivoa (najniže doze ili koncentracije u eksperimentu koja odstupa od normalnog odgovora) u toksikološkoj proceni rizika, kao i da prikaže najčešće korišćene softvere za njeno izračunavanje (BMDS i PROAST). Benchmark doza predstavlja statističku donju granicu pouzdanosti doze koja dovodi do malog povećanja efekta (5-10%) u odnosu na kontrolnu vrednost. Benchmark pristup predstavlja alternativu NOAEL (engl. no observed adverse effects level, NOAEL) pristupu, u kome se u svrhu dobijanja referentnih vrednosti koristi najviša doza koja ne izaziva štetan efekat. Benchmark pristup naučno je napredniji metod od tradicionalnog NOAEL pristupa, jer je statistički utemeljen, daje širok opseg podataka o odnosu doza-odgovor i omogućava kvantifikaciju njihove nesigurnosti i varijabilnosti. Takođe, BMD pristup doprinosi smanjenju broja eksperimentalnih životinja u toksikološkim studijama. Sami...m tim, Evropska agencija za bezbednost hrane (EFSA) preporučuje primenu doza BMDL10 za kvantalne i BMDL05 za kontinuirane podatke.

Keywords:
toxicology / risk assessment / benchmark dose / PROAST / BMDS / toksikologija / procena rizika / benchmark doza
Source:
Arhiv za farmaciju, 2020, 70, 3, 130-141
Publisher:
  • Beograd : Savez farmaceutskih udruženja Srbije

DOI: 10.5937/arhfarm2003130B

ISSN: 0004-1963

Scopus: 2-s2.0-85088903383
[ Google Scholar ]
5
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3644
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Baralić, Katarina
AU  - Javorac, Dragana
AU  - Antonijević, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3644
AB  - This  paper  aims  to  present  the  importance  of  the  benchmark  dose  (BMD)  as  a  point  of departure (the lowest dose or concentration in the experiment that deviates from the response that differs from the normal response) in toxicological risk assessment, as well as to present commonly used software for its calculation (BMDS and PROAST). Benchmark dose is defined as a statistical lower confidence limit of a dose that results in a small change in effect (5-10%) in comparison with the control value. The BMD approach is considered a substitution for the NOAEL approach, which uses the highest observed no-effect level (NOAEL) to obtain the reference dose. The BMD approach is a methodically more forward-thinking technique than the NOAEL approach because it has statistical power and provides a wide range of dose-response relationships and allows the determination of their uncertainty and  variability. Moreover, the  BMD approach contributes to the reduction of experimental animals in toxicity studies. Therefore, the European Food Safety Authority (EFSA) recommends the use of BMDL10values for quantal and BMDL05for continuous data.
AB  - Cilj ovog rada je da predstavi značaj granične benchmark doze (engl. benchmark dose, BMD) kao polaznog doznog nivoa (najniže doze ili koncentracije u eksperimentu koja odstupa od normalnog odgovora) u toksikološkoj proceni rizika, kao i da prikaže najčešće korišćene softvere za njeno izračunavanje (BMDS i PROAST). Benchmark doza predstavlja statističku donju granicu pouzdanosti doze koja dovodi do malog povećanja efekta (5-10%) u odnosu na kontrolnu vrednost. Benchmark pristup predstavlja alternativu NOAEL (engl. no observed adverse effects level, NOAEL) pristupu, u kome se u svrhu dobijanja referentnih vrednosti koristi najviša doza koja ne izaziva štetan efekat. Benchmark pristup naučno je napredniji metod od tradicionalnog NOAEL pristupa, jer je statistički utemeljen, daje širok opseg podataka o odnosu doza-odgovor i omogućava kvantifikaciju njihove nesigurnosti i varijabilnosti. Takođe, BMD pristup doprinosi smanjenju broja eksperimentalnih životinja u toksikološkim studijama. Samim tim, Evropska agencija za bezbednost hrane (EFSA) preporučuje primenu doza BMDL10 za kvantalne i BMDL05 za kontinuirane podatke.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - Relevance and evaluation of the benchmark dose in toxicology
T1  - Značaj i procena benchmark doze u toksikologiji
VL  - 70
IS  - 3
SP  - 130
EP  - 141
DO  - 10.5937/arhfarm2003130B
ER  - 
@article{
author = "Baralić, Katarina and Javorac, Dragana and Antonijević, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana",
year = "2020",
abstract = "This  paper  aims  to  present  the  importance  of  the  benchmark  dose  (BMD)  as  a  point  of departure (the lowest dose or concentration in the experiment that deviates from the response that differs from the normal response) in toxicological risk assessment, as well as to present commonly used software for its calculation (BMDS and PROAST). Benchmark dose is defined as a statistical lower confidence limit of a dose that results in a small change in effect (5-10%) in comparison with the control value. The BMD approach is considered a substitution for the NOAEL approach, which uses the highest observed no-effect level (NOAEL) to obtain the reference dose. The BMD approach is a methodically more forward-thinking technique than the NOAEL approach because it has statistical power and provides a wide range of dose-response relationships and allows the determination of their uncertainty and  variability. Moreover, the  BMD approach contributes to the reduction of experimental animals in toxicity studies. Therefore, the European Food Safety Authority (EFSA) recommends the use of BMDL10values for quantal and BMDL05for continuous data., Cilj ovog rada je da predstavi značaj granične benchmark doze (engl. benchmark dose, BMD) kao polaznog doznog nivoa (najniže doze ili koncentracije u eksperimentu koja odstupa od normalnog odgovora) u toksikološkoj proceni rizika, kao i da prikaže najčešće korišćene softvere za njeno izračunavanje (BMDS i PROAST). Benchmark doza predstavlja statističku donju granicu pouzdanosti doze koja dovodi do malog povećanja efekta (5-10%) u odnosu na kontrolnu vrednost. Benchmark pristup predstavlja alternativu NOAEL (engl. no observed adverse effects level, NOAEL) pristupu, u kome se u svrhu dobijanja referentnih vrednosti koristi najviša doza koja ne izaziva štetan efekat. Benchmark pristup naučno je napredniji metod od tradicionalnog NOAEL pristupa, jer je statistički utemeljen, daje širok opseg podataka o odnosu doza-odgovor i omogućava kvantifikaciju njihove nesigurnosti i varijabilnosti. Takođe, BMD pristup doprinosi smanjenju broja eksperimentalnih životinja u toksikološkim studijama. Samim tim, Evropska agencija za bezbednost hrane (EFSA) preporučuje primenu doza BMDL10 za kvantalne i BMDL05 za kontinuirane podatke.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Relevance and evaluation of the benchmark dose in toxicology, Značaj i procena benchmark doze u toksikologiji",
volume = "70",
number = "3",
pages = "130-141",
doi = "10.5937/arhfarm2003130B"
}
Baralić, K., Javorac, D., Antonijević, E., Buha-Đorđević, A., Ćurčić, M., Đukić-Ćosić, D., Bulat, Z.,& Antonijević, B.. (2020). Relevance and evaluation of the benchmark dose in toxicology. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 70(3), 130-141.
https://doi.org/10.5937/arhfarm2003130B
Baralić K, Javorac D, Antonijević E, Buha-Đorđević A, Ćurčić M, Đukić-Ćosić D, Bulat Z, Antonijević B. Relevance and evaluation of the benchmark dose in toxicology. in Arhiv za farmaciju. 2020;70(3):130-141.
doi:10.5937/arhfarm2003130B .
Baralić, Katarina, Javorac, Dragana, Antonijević, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, "Relevance and evaluation of the benchmark dose in toxicology" in Arhiv za farmaciju, 70, no. 3 (2020):130-141,
https://doi.org/10.5937/arhfarm2003130B . .

DSpace software copyright © 2002-2015  DuraSpace
About the RADaR Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceCollectionsAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About the RADaR Repository | Send Feedback

OpenAIRERCUB