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Synthesis and characterization of copper(II) octaazamacrocyclic complexes with glycine derivatives. In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous

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Synthesis_and_characterization_pub_2020.pdf (2.371Mb)
Authors
Dražić, Branka
Antonijević-Nikolić, Mirjana
Žižak, Željko
Tanasković, Slađana
Article (Published version)
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Abstract
Two new complexes with the general formula [Cu2(L)tpmc](ClO4)3·nH2O (tpmc = N,N′,N′′,N′′′-tetrakis(2-pyridylmethyl)- -1,4,8,11-tetraazacyclotetradecane, L = N-methylglycine, n = 3; L = N,N- -dimethylglycine, n = 2) were isolated and their composition, some physical and chemical properties and geometries were proposed based on elemental analysis (C, H, N), conductometric and magnetic measurements and spectro-scopic data (UV–Vis, FTIR). It is evident that the complexes are binuclear and an exo coordination mode of the macrocyclic ligand in the boat conformation was proposed. The co-ligands are coordinated as a bridge using both oxygen atoms of the OCO- group. The cytotoxic activity of Cu(II) complexes as well as their Co(II) analogs, the starting ligands and the free salts were tested against human cervix adenocarcinoma cell line (HeLa), human chronic myelo-genous leukemia cells (K562), human breast cancer cell line (MDA-MB-453), and a non-cancerou...s cell line, human embryonic lung fibroblast (MRC-5). The IC50 values for the Cu(II) complexes were from 21.6±0.04 to 66.1±0.8, and for the Co(II) analogs were within the range from 8.8±0.74 to 15.40±1.52. All four complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans.

Keywords:
Antimicrobial activity / Antiproliferative activity / Cu(II) and co(II) complexes / Octaazamacrocycle
Source:
Journal of the Serbian Chemical Society, 2020, 85, 5, 637-649
Publisher:
  • Belgrade : Serbian Chemical Society
Projects:
  • Design, synthesis, characterization and assessment of practical applications of coordination and organometallic compounds (RS-172014)

DOI: 10.2298/JSC190710088D

ISSN: 0352-5139

WoS: 000535935100005

Scopus: 2-s2.0-85089851091
[ Google Scholar ]
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3650
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy
TY  - JOUR
AU  - Dražić, Branka
AU  - Antonijević-Nikolić, Mirjana
AU  - Žižak, Željko
AU  - Tanasković, Slađana
PY  - 2020
UR  - http://farfar.pharmacy.bg.ac.rs/handle/123456789/3650
AB  - Two   new   complexes   with   the   general   formula [Cu2(L)tpmc](ClO4)3·nH2O  (tpmc  = N,N′,N′′,N′′′-tetrakis(2-pyridylmethyl)- -1,4,8,11-tetraazacyclotetradecane,  L  = N-methylglycine, n =  3;  L  = N,N- -dimethylglycine, n = 2) were isolated and their composition, some physical and  chemical  properties  and  geometries  were  proposed  based  on  elemental analysis (C, H, N), conductometric and magnetic measurements and spectro-scopic data (UV–Vis, FTIR). It is evident that the complexes are binuclear and an exo coordination mode of the macrocyclic ligand in the boat conformation was proposed. The co-ligands are coordinated as a bridge using both oxygen atoms of the OCO- group. The cytotoxic activity of Cu(II) complexes as well as  their  Co(II)  analogs,  the  starting  ligands  and  the  free  salts  were  tested against human cervix adenocarcinoma cell line (HeLa), human chronic myelo-genous leukemia cells (K562), human breast cancer cell line (MDA-MB-453), and a non-cancerous cell line, human embryonic lung fibroblast (MRC-5). The IC50 values for the Cu(II) complexes were from 21.6±0.04 to 66.1±0.8, and for the Co(II) analogs were within the range from 8.8±0.74 to 15.40±1.52. All four complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans.
PB  - Belgrade : Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Synthesis and characterization of copper(II) octaazamacrocyclic complexes with glycine derivatives. In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous
VL  - 85
IS  - 5
SP  - 637
EP  - 649
DO  - 10.2298/JSC190710088D
ER  - 
@article{
author = "Dražić, Branka and Antonijević-Nikolić, Mirjana and Žižak, Željko and Tanasković, Slađana",
year = "2020",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/3650",
abstract = "Two   new   complexes   with   the   general   formula [Cu2(L)tpmc](ClO4)3·nH2O  (tpmc  = N,N′,N′′,N′′′-tetrakis(2-pyridylmethyl)- -1,4,8,11-tetraazacyclotetradecane,  L  = N-methylglycine, n =  3;  L  = N,N- -dimethylglycine, n = 2) were isolated and their composition, some physical and  chemical  properties  and  geometries  were  proposed  based  on  elemental analysis (C, H, N), conductometric and magnetic measurements and spectro-scopic data (UV–Vis, FTIR). It is evident that the complexes are binuclear and an exo coordination mode of the macrocyclic ligand in the boat conformation was proposed. The co-ligands are coordinated as a bridge using both oxygen atoms of the OCO- group. The cytotoxic activity of Cu(II) complexes as well as  their  Co(II)  analogs,  the  starting  ligands  and  the  free  salts  were  tested against human cervix adenocarcinoma cell line (HeLa), human chronic myelo-genous leukemia cells (K562), human breast cancer cell line (MDA-MB-453), and a non-cancerous cell line, human embryonic lung fibroblast (MRC-5). The IC50 values for the Cu(II) complexes were from 21.6±0.04 to 66.1±0.8, and for the Co(II) analogs were within the range from 8.8±0.74 to 15.40±1.52. All four complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Synthesis and characterization of copper(II) octaazamacrocyclic complexes with glycine derivatives. In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous",
volume = "85",
number = "5",
pages = "637-649",
doi = "10.2298/JSC190710088D"
}
Dražić B, Antonijević-Nikolić M, Žižak Ž, Tanasković S. Synthesis and characterization of copper(II) octaazamacrocyclic complexes with glycine derivatives. In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous. Journal of the Serbian Chemical Society. 2020;85(5):637-649
Dražić, B., Antonijević-Nikolić, M., Žižak, Ž.,& Tanasković, S. (2020). Synthesis and characterization of copper(II) octaazamacrocyclic complexes with glycine derivatives. In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous.
Journal of the Serbian Chemical SocietyBelgrade : Serbian Chemical Society., 85(5), 637-649.
https://doi.org/10.2298/JSC190710088D
Dražić Branka, Antonijević-Nikolić Mirjana, Žižak Željko, Tanasković Slađana, "Synthesis and characterization of copper(II) octaazamacrocyclic complexes with glycine derivatives. In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous" 85, no. 5 (2020):637-649,
https://doi.org/10.2298/JSC190710088D .

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