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dc.creatorDražić, Branka
dc.creatorAntonijević-Nikolić, Mirjana
dc.creatorŽižak, Željko
dc.creatorTanasković, Slađana
dc.date.accessioned2020-09-02T08:24:24Z
dc.date.available2020-09-02T08:24:24Z
dc.date.issued2020
dc.identifier.issn0352-5139
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3650
dc.description.abstractTwo new complexes with the general formula [Cu2(L)tpmc](ClO4)3·nH2O (tpmc = N,N′,N′′,N′′′-tetrakis(2-pyridylmethyl)- -1,4,8,11-tetraazacyclotetradecane, L = N-methylglycine, n = 3; L = N,N- -dimethylglycine, n = 2) were isolated and their composition, some physical and chemical properties and geometries were proposed based on elemental analysis (C, H, N), conductometric and magnetic measurements and spectro-scopic data (UV–Vis, FTIR). It is evident that the complexes are binuclear and an exo coordination mode of the macrocyclic ligand in the boat conformation was proposed. The co-ligands are coordinated as a bridge using both oxygen atoms of the OCO- group. The cytotoxic activity of Cu(II) complexes as well as their Co(II) analogs, the starting ligands and the free salts were tested against human cervix adenocarcinoma cell line (HeLa), human chronic myelo-genous leukemia cells (K562), human breast cancer cell line (MDA-MB-453), and a non-cancerous cell line, human embryonic lung fibroblast (MRC-5). The IC50 values for the Cu(II) complexes were from 21.6±0.04 to 66.1±0.8, and for the Co(II) analogs were within the range from 8.8±0.74 to 15.40±1.52. All four complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans.en
dc.publisherBelgrade : Serbian Chemical Society
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172014/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of the Serbian Chemical Society
dc.subjectAntimicrobial activity
dc.subjectAntiproliferative activity
dc.subjectCu(II) and co(II) complexes
dc.subjectOctaazamacrocycle
dc.titleSynthesis and characterization of copper(II) octaazamacrocyclic complexes with glycine derivatives. In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogousen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractЖижак, Жељко; Танасковић, Слађана; Aнтонијевић-Николић, Мирјана; Дражић, Бранка;
dc.citation.volume85
dc.citation.issue5
dc.citation.spage637
dc.citation.epage649
dc.citation.rankM23
dc.identifier.wos000535935100005
dc.identifier.doi10.2298/JSC190710088D
dc.identifier.scopus2-s2.0-85089851091
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs/bitstream/id/8030/Synthesis_and_characterization_pub_2020.pdf
dc.type.versionpublishedVersion


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