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dc.creatorBuha, Aleksandra
dc.creatorĐukić-Ćosić, Danijela
dc.creatorĆurčić, Marijana
dc.creatorBulat, Zorica
dc.creatorAntonijević, Biljana
dc.creatorMoulis, Jean-Marc
dc.creatorGoumenou, Marina
dc.creatorWallace, David
dc.date.accessioned2020-09-22T13:22:54Z
dc.date.available2020-09-22T13:22:54Z
dc.date.issued2020
dc.identifier.issn2305-6304
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3659
dc.description.abstractRecent research has helped clarify the role of cadmium (Cd) in various pathological states. We have demonstrated Cd involvement in pancreatic cancer, as well as the bioaccumulation of Cd in the pancreas. Bioaccumulation and increased toxicity suggest that Cd may also be involved in other pancreas-mediated diseases, like diabetes. Cd falls into the category of "hyperglycemic" metals, i.e., metals that increase blood glucose levels, which could be due to increased gluconeogenesis, damage to β-cells leading to reduced insulin production, or insulin resistance at target tissue resulting in a lack of glucose uptake. This review addresses the current evidence for the role of Cd, leading to insulin resistance from human, animal, and in vitro studies. Available data have shown that Cd may affect normal insulin function through multiple pathways. There is evidence that Cd exposure results in the perturbation of the enzymes and modulatory proteins involved in insulin signal transduction at the target tissue and mutations of the insulin receptor. Cd, through well-described mechanisms of oxidative stress, inflammation, and mitochondrial damage, may also alter insulin production in β-cells. More work is necessary to elucidate the mechanisms associated with Cd-mediated insulin resistance.
dc.publisherMDPI AG
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.relationOklahoma State UniversityCenter for Health Sciences Pilot/Seed Grant (1-54357; D.W.)
dc.rightsopenAccess
dc.sourceToxics
dc.subjectCadmium
dc.subjectDiabetes
dc.subjectHyperglycemia
dc.subjectHyperinsulinemia
dc.subjectInsulin
dc.subjectLipogenic
dc.subjectß-cell toxicity
dc.titleEmerging links between cadmium exposure and insulin resistance: Human, animal, and cell study data
dc.typearticle
dc.rights.licenseBY
dcterms.abstractЋурчић, Маријана; Буха, Aлександра; Ђукић-Ћосић, Данијела; Wаллаце, Давид; Гоуменоу, Марина; Моулис, Јеан-Марц; Aнтонијевић, Биљана; Булат, Зорица;
dc.citation.volume8
dc.citation.issue3
dc.identifier.doi10.3390/TOXICS8030063
dc.identifier.scopus2-s2.0-85090587413
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/8069/Emerging_Links_between_pub_2020.pdf
dc.type.versionpublishedVersion


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