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dc.creatorIgnjatović, Janko
dc.creatorMaljurić, Nevena
dc.creatorGolubović, Jelena
dc.creatorRavnikar, Matjaž
dc.creatorPetković, Miloš
dc.creatorSavodnik, Nika
dc.creatorŠtrukelj, Borut
dc.creatorOtašević, Biljana
dc.date.accessioned2020-09-22T14:43:24Z
dc.date.available2020-09-22T14:43:24Z
dc.date.issued2020
dc.identifier.issn1318-0207
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3661
dc.description.abstractRecently, growing interest is devoted to investigation of bioactive secondary metabolites of endophytic fungi. Thus, as an extension to our previous achievements related to antimicrobial potential of endophytic fungi, Phomopsis species isolated from conifer needles was selected as appropriately promising natural source for drug discovery. Its dichloromethane and ethanol extracts considerably inhibited growth of Escherichia coli and Staphylococcus aureus. Moreover, the indi-vidual compounds of dichloromethane extract have been separated, collected and purified using semi preparative liquid chromatographic analysis and comprehensively characterized using mass spectrometry (MS) and nuclear magnetic res-onance spectroscopy (NMR). Based on their antimicrobial activity and unique structural characteristics in comparison with well-established drugs from the same therapeutic category, two dominant compounds (Z)-(Z)-2-acetoxyprop-1-en-1-yl-3-(3-((E)-3,4-dihydroxypent-1-en-1-yl)oxiran-2-yl)acrylate (denoted as 325-3) and (Z)-(Z)-2-acetoxyprop-1-en-1-yl 3-(3-((E)-4-hydroxy-3-oxopent-1-en-1-yl)oxiran-2-yl)acrylate (denoted as 325-5) were recognized as valuable leading structures for future discovery of novel antibiotics.
dc.publisherSlovenian Chemical Society
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172033/RS//
dc.relationSlovenian Re-search Agency (grant number P4-0127)
dc.relationEU (project no. BI-RS/16-17-022).
dc.rightsopenAccess
dc.sourceActa Chimica Slovenica
dc.subjectAntibacterial activity
dc.subjectEndophytic fungi
dc.subjectGC-MS
dc.subjectHPLC
dc.subjectNMR
dc.titleCharacterization of biomolecules with antibiotic activity from endophytic fungi phomopsis species
dc.typearticle
dc.rights.licenseBY
dcterms.abstractГолубовић, Јелена; Саводник, Ника; Равникар, Матјаж; Игњатовић, Јанко; Штрукељ, Борут; Петковић, Милош; Оташевић, Биљана; Маљурић, Невена;
dc.citation.volume67
dc.citation.issue2
dc.citation.spage445
dc.citation.epage461
dc.identifier.wos000541748400010
dc.identifier.doi10.17344/acsi.2019.5389
dc.identifier.scopus2-s2.0-85090516475
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/8071/Characterization_of_Biomolecules_pub_2020.pdf
dc.type.versionpublishedVersion


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