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Antifungal activity of the esssential oil of seseli rigidum waldst. & kit. (apiaceae) on the growth of isolates of candida albicans

Antifungalna aktivnost etarskog ulja seseli rigidum waldst. & kit. (apiaceae) na rast izolata candida albicans

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2019
Antifungalna_aktivnost_etarskog_pub_2019.pdf (285.0Kb)
Authors
Marčetić, Mirjana
Božić, Dragana
Milenković, Marina
Kovačević, Mirjana
Kovačević, Nada
Article (Published version)
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Abstract
Ispitivano je delovanje etarskih ulja korena, herbe i ploda devesilja, Seseli rigidum iz dve prirodne populacije na 28 izolata Candida albicans i jedan standardni soj C. albicans ATCC 10259. Sojevi C. albicans koji su korišćeni u ovom ispitivanju izolovani su iz orofaringealnog brisa, vaginalnog i/ili cervikalnog brisa, brisa oka, brisa rane, fecesa i urina. Ispitivani sojevi su pokazali visok stepen rezistencije prema delovanju kontrolnog antimikotika flukonazola, a u nešto manjoj meri i amfotericina B. Etarska ulja devesilja, primenjena u koncentracijama 50-200 μg/ml, uzrokovala su inhibiciju rasta ispitivanih sojeva (28,6-46,4% testiranih sojeva). Inhibitorni efekat na tri soja C. albicans ostvaren je sa etarskim uljem korena, sa oba lokaliteta, već pri koncentraciji od 50 μg/ml. Dominantno jedinjenje u ovim etarskim uljima je predstavljao falkarinol (57,5% i 88,8%). Slabiju aktivnost su ispoljila etarska ulje herbe i ploda devesilja, koja su u konc...entraciji od 100 μg/ml inhibirala rast pojedinih ispitivanih sojeva. Kod etarskog ulja ploda uočeno je nešto izraženije delovanje etarskog ulja populacije iz Brđanske klisure, koje je sadržalo veću količinu α-pinena i β-felandrena, a manju količinu sabinena. Dobijeni rezultati su pokazali da etarska ulja korena, herbe i ploda devesilja ispoljavaju značajnu antifungalnu aktivnost na pojedine rezistentne sojeve C. albicans.

The antimicrobial activity of the essential oils of root, aerial parts and fruit from two natural populations of Seseli rigidum was tested against 28 isolates of Candida albicans and one laboratory control strain of C. albicans ATCC 10259. Strains of C. albicans were isolated from oropharyngeal swabs, vaginal and/or cervical swabs, eye swabs, wound swabs, feces and urine. The investigated strains showed high level of resistance towards the activity of control antimycotic agent fluconazole and to a lower extent towards amphotericin B. The S. rigidum essential oils, in the concentrations of 50-200 μg/ml, inhibited the growth of investigated strains (28.6-46.4% of tested strains). The essential oils of root from both localities showed antifungal effect at the concentration 50 μg/ml. The dominant compound in the root essential oils was falcarinol (57.5% and 88.8%). The lower activity was obtained with the essential oil of aerial parts or fruit. The 100 μg/ml of essential oil of aerial part...s showed significant effect on C. albicans strains. The essential oil of fruit from population from Brdjanska gorge exerted somehow higher effect. It was characterised by higher α-pinene and β-phellandrene content and lower amount of sabinene. The obtained results revealed the significant antifungal effects of S. rigidum root, aerial parts and fruit essential oils against resistant strains of C. albicans.

Keywords:
Antifungal activity / Candida albicans / Essential oil / Seseli rigidum / antifungalna aktivnost / Seseli rigidum / etarsko ulje / Candida albicans
Source:
Arhiv za farmaciju, 2019, 69, 2, 67-79
Publisher:
  • Pharmaceutical Association of Serbia
Projects:
  • Investigation on the medicinal plants: morphological, chemical and pharmacological characterisation (RS-173021)

DOI: 10.5937/arhfarm1902067x

ISSN: 0004-1963

Scopus: 2-s2.0-85090679845
[ Google Scholar ]
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3664
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy
TY  - JOUR
AU  - Marčetić, Mirjana
AU  - Božić, Dragana
AU  - Milenković, Marina
AU  - Kovačević, Mirjana
AU  - Kovačević, Nada
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3664
AB  - Ispitivano je delovanje etarskih ulja korena, herbe i ploda devesilja, Seseli rigidum iz dve prirodne populacije na 28 izolata Candida  albicans  i jedan standardni soj C.  albicans  ATCC 10259. Sojevi C. albicans koji su korišćeni u ovom ispitivanju izolovani su iz orofaringealnog brisa, vaginalnog i/ili cervikalnog brisa, brisa oka, brisa rane, fecesa i urina.  Ispitivani  sojevi  su  pokazali  visok  stepen  rezistencije  prema  delovanju  kontrolnog antimikotika  flukonazola,  a  u  nešto  manjoj  meri  i  amfotericina B.  Etarska  ulja  devesilja, primenjena u koncentracijama 50-200 μg/ml, uzrokovala su inhibiciju rasta ispitivanih sojeva (28,6-46,4% testiranih sojeva). Inhibitorni efekat na tri soja C. albicans ostvaren je sa etarskim uljem korena, sa oba lokaliteta, već pri koncentraciji od 50 μg/ml. Dominantno jedinjenje u ovim etarskim uljima je predstavljao falkarinol (57,5% i 88,8%). Slabiju aktivnost su ispoljila etarska  ulje  herbe  i  ploda  devesilja,  koja  su  u  koncentraciji  od  100  μg/ml  inhibirala  rast pojedinih  ispitivanih  sojeva.  Kod  etarskog  ulja  ploda  uočeno  je  nešto  izraženije  delovanje etarskog  ulja  populacije  iz  Brđanske  klisure,  koje  je  sadržalo veću  količinu  α-pinena  i                         β-felandrena, a manju količinu sabinena.  Dobijeni rezultati su pokazali da etarska ulja korena, herbe i ploda devesilja ispoljavaju značajnu antifungalnu aktivnost na pojedine rezistentne sojeve C. albicans.
AB  - The antimicrobial activity of the essential oils of root, aerial parts and fruit from two natural populations of Seseli rigidum was tested against 28 isolates of Candida albicans and one laboratory control strain of C. albicans ATCC 10259. Strains of C. albicans were isolated from oropharyngeal swabs, vaginal and/or cervical swabs, eye swabs, wound swabs, feces and urine. The investigated strains showed high level of resistance towards the activity of control antimycotic agent fluconazole and to a lower extent towards amphotericin B. The S. rigidum essential oils, in the concentrations of 50-200 μg/ml, inhibited the growth of investigated strains (28.6-46.4% of tested strains). The essential oils of root from both localities showed antifungal effect at the concentration 50 μg/ml. The dominant compound in the root essential oils was falcarinol (57.5% and 88.8%). The lower activity was obtained with the essential oil of aerial parts or fruit. The 100 μg/ml of essential oil of aerial parts showed significant effect on C. albicans strains. The essential oil of fruit from population from Brdjanska gorge exerted somehow higher effect. It was characterised by higher α-pinene and β-phellandrene content and lower amount of sabinene. The obtained results revealed the significant antifungal effects of S. rigidum root, aerial parts and fruit essential oils against resistant strains of C. albicans.
PB  - Pharmaceutical Association of Serbia
T2  - Arhiv za farmaciju
T1  - Antifungal activity of the esssential oil of seseli rigidum waldst. & kit. (apiaceae) on the growth of isolates of candida albicans
T1  - Antifungalna aktivnost etarskog ulja seseli rigidum waldst. & kit. (apiaceae) na rast izolata candida albicans
VL  - 69
IS  - 2
SP  - 67
EP  - 79
DO  - 10.5937/arhfarm1902067x
ER  - 
@article{
author = "Marčetić, Mirjana and Božić, Dragana and Milenković, Marina and Kovačević, Mirjana and Kovačević, Nada",
year = "2019",
url = "https://farfar.pharmacy.bg.ac.rs/handle/123456789/3664",
abstract = "Ispitivano je delovanje etarskih ulja korena, herbe i ploda devesilja, Seseli rigidum iz dve prirodne populacije na 28 izolata Candida  albicans  i jedan standardni soj C.  albicans  ATCC 10259. Sojevi C. albicans koji su korišćeni u ovom ispitivanju izolovani su iz orofaringealnog brisa, vaginalnog i/ili cervikalnog brisa, brisa oka, brisa rane, fecesa i urina.  Ispitivani  sojevi  su  pokazali  visok  stepen  rezistencije  prema  delovanju  kontrolnog antimikotika  flukonazola,  a  u  nešto  manjoj  meri  i  amfotericina B.  Etarska  ulja  devesilja, primenjena u koncentracijama 50-200 μg/ml, uzrokovala su inhibiciju rasta ispitivanih sojeva (28,6-46,4% testiranih sojeva). Inhibitorni efekat na tri soja C. albicans ostvaren je sa etarskim uljem korena, sa oba lokaliteta, već pri koncentraciji od 50 μg/ml. Dominantno jedinjenje u ovim etarskim uljima je predstavljao falkarinol (57,5% i 88,8%). Slabiju aktivnost su ispoljila etarska  ulje  herbe  i  ploda  devesilja,  koja  su  u  koncentraciji  od  100  μg/ml  inhibirala  rast pojedinih  ispitivanih  sojeva.  Kod  etarskog  ulja  ploda  uočeno  je  nešto  izraženije  delovanje etarskog  ulja  populacije  iz  Brđanske  klisure,  koje  je  sadržalo veću  količinu  α-pinena  i                         β-felandrena, a manju količinu sabinena.  Dobijeni rezultati su pokazali da etarska ulja korena, herbe i ploda devesilja ispoljavaju značajnu antifungalnu aktivnost na pojedine rezistentne sojeve C. albicans., The antimicrobial activity of the essential oils of root, aerial parts and fruit from two natural populations of Seseli rigidum was tested against 28 isolates of Candida albicans and one laboratory control strain of C. albicans ATCC 10259. Strains of C. albicans were isolated from oropharyngeal swabs, vaginal and/or cervical swabs, eye swabs, wound swabs, feces and urine. The investigated strains showed high level of resistance towards the activity of control antimycotic agent fluconazole and to a lower extent towards amphotericin B. The S. rigidum essential oils, in the concentrations of 50-200 μg/ml, inhibited the growth of investigated strains (28.6-46.4% of tested strains). The essential oils of root from both localities showed antifungal effect at the concentration 50 μg/ml. The dominant compound in the root essential oils was falcarinol (57.5% and 88.8%). The lower activity was obtained with the essential oil of aerial parts or fruit. The 100 μg/ml of essential oil of aerial parts showed significant effect on C. albicans strains. The essential oil of fruit from population from Brdjanska gorge exerted somehow higher effect. It was characterised by higher α-pinene and β-phellandrene content and lower amount of sabinene. The obtained results revealed the significant antifungal effects of S. rigidum root, aerial parts and fruit essential oils against resistant strains of C. albicans.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "Antifungal activity of the esssential oil of seseli rigidum waldst. & kit. (apiaceae) on the growth of isolates of candida albicans, Antifungalna aktivnost etarskog ulja seseli rigidum waldst. & kit. (apiaceae) na rast izolata candida albicans",
volume = "69",
number = "2",
pages = "67-79",
doi = "10.5937/arhfarm1902067x"
}
Marčetić M, Božić D, Milenković M, Kovačević M, Kovačević N. Antifungalna aktivnost etarskog ulja seseli rigidum waldst. & kit. (apiaceae) na rast izolata candida albicans. Arhiv za farmaciju. 2019;69(2):67-79
Marčetić, M., Božić, D., Milenković, M., Kovačević, M.,& Kovačević, N. (2019). Antifungalna aktivnost etarskog ulja seseli rigidum waldst. & kit. (apiaceae) na rast izolata candida albicans.
Arhiv za farmacijuPharmaceutical Association of Serbia., 69(2), 67-79.
https://doi.org/10.5937/arhfarm1902067x
Marčetić Mirjana, Božić Dragana, Milenković Marina, Kovačević Mirjana, Kovačević Nada, "Antifungalna aktivnost etarskog ulja seseli rigidum waldst. & kit. (apiaceae) na rast izolata candida albicans" 69, no. 2 (2019):67-79,
https://doi.org/10.5937/arhfarm1902067x .

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