Degradation kinetics and characterization of degradation products of losartan potassium by lc-ms/ms method
Kinetika degradacije i karakterizacija degradacionih proizvoda losartan kalijuma lcms/ms metodom
Article (Published version)
Metadata
Show full item recordAbstract
U ovom radu opisano je ispitivanje stabilnosti losartan kalijuma primenom tečne hromatografije sa UV i MS-MS detekcijom i prikazan je njegov profil degradacionih proizvoda. Rastvor losartan kalijuma bio je izložen dejstvu sledećih stres agenasa: 0,1 M HCl; 0,1 M NaOH i 3% (v/v) H2O2. Rastvori losartan kalijuma analizirani su gradijentnim eluiranjem sa acetonitrilom i 0,1% (v/v) vodenim rastvorom CF3COOH pri konstantnom protoku od 0,5 ml min-1 i vremenom trajanja od 22 min. Degradacija u rastvorima losartan kalijuma koji su 7 dana bili izloženi dejstvu 0,1 M HCl i 0,1 M NaOH bila je manja od 1%, dok je u prisustvu 3% (v/v) H2O2 bila značajno veća (oko 10%). Identifikacija i strukturna analiza glavnih degradacionih proizvoda losartan kalijuma izvršena je primenom LC-MS/MS metode. Grafička zavisnost izmerenih koncentracija u funkciji vremena ukazuje da se losartan kalijum u rastvoru 3% (v/v) H2O2 degradira ...kinetikom pseudo nultog reda sa konstantnom brzine reakcije od 1.48ꞏ10-8 mol L-1 dan-1.
This paper presents study of losartan potassium stability evaluation by liquid chromatography with UV/VIS and MS-MS detection and its degradation profile. A solution of losartan potassium was exposed to the following stress agents: 0.1 M HCl, 0.1 M NaOH, and 3% (v/v) H2O2. The analyses of losartan potassium solutions were carried out in a gradient elution mode with acetonitrile and 0.1% (v/v) CF3COOH aqueous solution and constant flow rate of 0.5 mL min-1 within 22 min run time. After 7 days of losartan potassium solutions exposure to the stress agents at room temperature, it was found that the degree of degradation in the presence of 0.1 M HCl and 0.1 M NaOH was less than 1%, while in the presence of 3% H2O2 degradation was significantly higher (about 10%). Chemical structure elucidation of the major degradation products of losartan potassium was performed using LC-MS/MS method. The concentration versus time plot indicated that in 3% (v/v) H2O2 solution losartan potassium was degraded... according to the pseudo zero-order reaction kinetics with 1.4810-8 mol L-1 day-1 rate constant. © 2019, Pharmaceutical Association of Serbia. All rights reserved.
Keywords:
Forced degradation / Kinetics / LC-MS/MS / Losartan potassium / Losartan kalijum / Forsirana degradacija / Kinetika / LC-MS/MSSource:
Arhiv za farmaciju, 2019, 69, 2, 80-89Publisher:
- Pharmaceutical Association of Serbia
Funding / projects:
- Development of molecules with antiinflammatory and cardioprotective activity: structural modifications, modelling, physicochemical characterization and formulation investigations (RS-172041)
- Development of micro- and nanosystems as carriers for drugs with anti-inflammatory effect and methods for their characterization (RS-34031)
Collections
Institution/Community
PharmacyTY - JOUR AU - Dobričić, Vladimir AU - Marković, Bojan PY - 2019 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3665 AB - U ovom radu opisano je ispitivanje stabilnosti losartan kalijuma primenom tečne hromatografije sa UV i MS-MS detekcijom i prikazan je njegov profil degradacionih proizvoda. Rastvor losartan kalijuma bio je izložen dejstvu sledećih stres agenasa: 0,1 M HCl; 0,1 M NaOH i 3% (v/v) H2O2. Rastvori losartan kalijuma analizirani su gradijentnim eluiranjem sa acetonitrilom i 0,1% (v/v) vodenim rastvorom CF3COOH pri konstantnom protoku od 0,5 ml min-1 i vremenom trajanja od 22 min. Degradacija u rastvorima losartan kalijuma koji su 7 dana bili izloženi dejstvu 0,1 M HCl i 0,1 M NaOH bila je manja od 1%, dok je u prisustvu 3% (v/v) H2O2 bila značajno veća (oko 10%). Identifikacija i strukturna analiza glavnih degradacionih proizvoda losartan kalijuma izvršena je primenom LC-MS/MS metode. Grafička zavisnost izmerenih koncentracija u funkciji vremena ukazuje da se losartan kalijum u rastvoru 3% (v/v) H2O2 degradira kinetikom pseudo nultog reda sa konstantnom brzine reakcije od 1.48ꞏ10-8 mol L-1 dan-1. AB - This paper presents study of losartan potassium stability evaluation by liquid chromatography with UV/VIS and MS-MS detection and its degradation profile. A solution of losartan potassium was exposed to the following stress agents: 0.1 M HCl, 0.1 M NaOH, and 3% (v/v) H2O2. The analyses of losartan potassium solutions were carried out in a gradient elution mode with acetonitrile and 0.1% (v/v) CF3COOH aqueous solution and constant flow rate of 0.5 mL min-1 within 22 min run time. After 7 days of losartan potassium solutions exposure to the stress agents at room temperature, it was found that the degree of degradation in the presence of 0.1 M HCl and 0.1 M NaOH was less than 1%, while in the presence of 3% H2O2 degradation was significantly higher (about 10%). Chemical structure elucidation of the major degradation products of losartan potassium was performed using LC-MS/MS method. The concentration versus time plot indicated that in 3% (v/v) H2O2 solution losartan potassium was degraded according to the pseudo zero-order reaction kinetics with 1.4810-8 mol L-1 day-1 rate constant. © 2019, Pharmaceutical Association of Serbia. All rights reserved. PB - Pharmaceutical Association of Serbia T2 - Arhiv za farmaciju T1 - Degradation kinetics and characterization of degradation products of losartan potassium by lc-ms/ms method T1 - Kinetika degradacije i karakterizacija degradacionih proizvoda losartan kalijuma lcms/ms metodom VL - 69 IS - 2 SP - 80 EP - 89 DO - 10.5937/arhfarm1902080X ER -
@article{ author = "Dobričić, Vladimir and Marković, Bojan", year = "2019", abstract = "U ovom radu opisano je ispitivanje stabilnosti losartan kalijuma primenom tečne hromatografije sa UV i MS-MS detekcijom i prikazan je njegov profil degradacionih proizvoda. Rastvor losartan kalijuma bio je izložen dejstvu sledećih stres agenasa: 0,1 M HCl; 0,1 M NaOH i 3% (v/v) H2O2. Rastvori losartan kalijuma analizirani su gradijentnim eluiranjem sa acetonitrilom i 0,1% (v/v) vodenim rastvorom CF3COOH pri konstantnom protoku od 0,5 ml min-1 i vremenom trajanja od 22 min. Degradacija u rastvorima losartan kalijuma koji su 7 dana bili izloženi dejstvu 0,1 M HCl i 0,1 M NaOH bila je manja od 1%, dok je u prisustvu 3% (v/v) H2O2 bila značajno veća (oko 10%). Identifikacija i strukturna analiza glavnih degradacionih proizvoda losartan kalijuma izvršena je primenom LC-MS/MS metode. Grafička zavisnost izmerenih koncentracija u funkciji vremena ukazuje da se losartan kalijum u rastvoru 3% (v/v) H2O2 degradira kinetikom pseudo nultog reda sa konstantnom brzine reakcije od 1.48ꞏ10-8 mol L-1 dan-1., This paper presents study of losartan potassium stability evaluation by liquid chromatography with UV/VIS and MS-MS detection and its degradation profile. A solution of losartan potassium was exposed to the following stress agents: 0.1 M HCl, 0.1 M NaOH, and 3% (v/v) H2O2. The analyses of losartan potassium solutions were carried out in a gradient elution mode with acetonitrile and 0.1% (v/v) CF3COOH aqueous solution and constant flow rate of 0.5 mL min-1 within 22 min run time. After 7 days of losartan potassium solutions exposure to the stress agents at room temperature, it was found that the degree of degradation in the presence of 0.1 M HCl and 0.1 M NaOH was less than 1%, while in the presence of 3% H2O2 degradation was significantly higher (about 10%). Chemical structure elucidation of the major degradation products of losartan potassium was performed using LC-MS/MS method. The concentration versus time plot indicated that in 3% (v/v) H2O2 solution losartan potassium was degraded according to the pseudo zero-order reaction kinetics with 1.4810-8 mol L-1 day-1 rate constant. © 2019, Pharmaceutical Association of Serbia. All rights reserved.", publisher = "Pharmaceutical Association of Serbia", journal = "Arhiv za farmaciju", title = "Degradation kinetics and characterization of degradation products of losartan potassium by lc-ms/ms method, Kinetika degradacije i karakterizacija degradacionih proizvoda losartan kalijuma lcms/ms metodom", volume = "69", number = "2", pages = "80-89", doi = "10.5937/arhfarm1902080X" }
Dobričić, V.,& Marković, B.. (2019). Degradation kinetics and characterization of degradation products of losartan potassium by lc-ms/ms method. in Arhiv za farmaciju Pharmaceutical Association of Serbia., 69(2), 80-89. https://doi.org/10.5937/arhfarm1902080X
Dobričić V, Marković B. Degradation kinetics and characterization of degradation products of losartan potassium by lc-ms/ms method. in Arhiv za farmaciju. 2019;69(2):80-89. doi:10.5937/arhfarm1902080X .
Dobričić, Vladimir, Marković, Bojan, "Degradation kinetics and characterization of degradation products of losartan potassium by lc-ms/ms method" in Arhiv za farmaciju, 69, no. 2 (2019):80-89, https://doi.org/10.5937/arhfarm1902080X . .