Show simple item record

Kinetika degradacije i karakterizacija degradacionih proizvoda losartan kalijuma lcms/ms metodom

dc.creatorDobričić, Vladimir
dc.creatorMarković, Bojan
dc.date.accessioned2020-09-22T16:43:23Z
dc.date.available2020-09-22T16:43:23Z
dc.date.issued2019
dc.identifier.issn0004-1963
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3665
dc.description.abstractU ovom radu opisano je ispitivanje stabilnosti losartan kalijuma primenom tečne hromatografije sa UV i MS-MS detekcijom i prikazan je njegov profil degradacionih proizvoda. Rastvor losartan kalijuma bio je izložen dejstvu sledećih stres agenasa: 0,1 M HCl; 0,1 M NaOH i 3% (v/v) H2O2. Rastvori losartan kalijuma analizirani su gradijentnim eluiranjem sa acetonitrilom i 0,1% (v/v) vodenim rastvorom CF3COOH pri konstantnom protoku od 0,5 ml min-1 i vremenom trajanja od 22 min. Degradacija u rastvorima losartan kalijuma koji su 7 dana bili izloženi dejstvu 0,1 M HCl i 0,1 M NaOH bila je manja od 1%, dok je u prisustvu 3% (v/v) H2O2 bila značajno veća (oko 10%). Identifikacija i strukturna analiza glavnih degradacionih proizvoda losartan kalijuma izvršena je primenom LC-MS/MS metode. Grafička zavisnost izmerenih koncentracija u funkciji vremena ukazuje da se losartan kalijum u rastvoru 3% (v/v) H2O2 degradira kinetikom pseudo nultog reda sa konstantnom brzine reakcije od 1.48ꞏ10-8 mol L-1 dan-1.
dc.description.abstractThis paper presents study of losartan potassium stability evaluation by liquid chromatography with UV/VIS and MS-MS detection and its degradation profile. A solution of losartan potassium was exposed to the following stress agents: 0.1 M HCl, 0.1 M NaOH, and 3% (v/v) H2O2. The analyses of losartan potassium solutions were carried out in a gradient elution mode with acetonitrile and 0.1% (v/v) CF3COOH aqueous solution and constant flow rate of 0.5 mL min-1 within 22 min run time. After 7 days of losartan potassium solutions exposure to the stress agents at room temperature, it was found that the degree of degradation in the presence of 0.1 M HCl and 0.1 M NaOH was less than 1%, while in the presence of 3% H2O2 degradation was significantly higher (about 10%). Chemical structure elucidation of the major degradation products of losartan potassium was performed using LC-MS/MS method. The concentration versus time plot indicated that in 3% (v/v) H2O2 solution losartan potassium was degraded according to the pseudo zero-order reaction kinetics with 1.4810-8 mol L-1 day-1 rate constant. © 2019, Pharmaceutical Association of Serbia. All rights reserved.
dc.publisherPharmaceutical Association of Serbia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//
dc.rightsopenAccess
dc.sourceArhiv za Farmaciju
dc.subjectForced degradation
dc.subjectKinetics
dc.subjectLC-MS/MS
dc.subjectLosartan potassium
dc.subjectLosartan kalijum
dc.subjectForsirana degradacija
dc.subjectKinetika
dc.subjectLC-MS/MS
dc.titleDegradation kinetics and characterization of degradation products of losartan potassium by lc-ms/ms method
dc.titleKinetika degradacije i karakterizacija degradacionih proizvoda losartan kalijuma lcms/ms metodom
dc.typearticle
dc.rights.licenseBY-SA
dcterms.abstractМарковић, Бојан; Добричић, Владимир; Кинетика деградације и карактеризација деградационих производа лосартан калијума лцмс/мс методом;
dc.citation.volume69
dc.citation.issue2
dc.citation.spage80
dc.citation.epage89
dc.identifier.doi10.5937/arhfarm1902080X
dc.identifier.scopus2-s2.0-85090640124
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/8075/Degradation_Kinetics_and_pub_2019.pdf
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record