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Degradation kinetics and characterization of degradation products of losartan potassium by lc-ms/ms method
Kinetika degradacije i karakterizacija degradacionih proizvoda losartan kalijuma lcms/ms metodom
dc.creator | Dobričić, Vladimir | |
dc.creator | Marković, Bojan | |
dc.date.accessioned | 2020-09-22T16:43:23Z | |
dc.date.available | 2020-09-22T16:43:23Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0004-1963 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3665 | |
dc.description.abstract | U ovom radu opisano je ispitivanje stabilnosti losartan kalijuma primenom tečne hromatografije sa UV i MS-MS detekcijom i prikazan je njegov profil degradacionih proizvoda. Rastvor losartan kalijuma bio je izložen dejstvu sledećih stres agenasa: 0,1 M HCl; 0,1 M NaOH i 3% (v/v) H2O2. Rastvori losartan kalijuma analizirani su gradijentnim eluiranjem sa acetonitrilom i 0,1% (v/v) vodenim rastvorom CF3COOH pri konstantnom protoku od 0,5 ml min-1 i vremenom trajanja od 22 min. Degradacija u rastvorima losartan kalijuma koji su 7 dana bili izloženi dejstvu 0,1 M HCl i 0,1 M NaOH bila je manja od 1%, dok je u prisustvu 3% (v/v) H2O2 bila značajno veća (oko 10%). Identifikacija i strukturna analiza glavnih degradacionih proizvoda losartan kalijuma izvršena je primenom LC-MS/MS metode. Grafička zavisnost izmerenih koncentracija u funkciji vremena ukazuje da se losartan kalijum u rastvoru 3% (v/v) H2O2 degradira kinetikom pseudo nultog reda sa konstantnom brzine reakcije od 1.48ꞏ10-8 mol L-1 dan-1. | sr |
dc.description.abstract | This paper presents study of losartan potassium stability evaluation by liquid chromatography with UV/VIS and MS-MS detection and its degradation profile. A solution of losartan potassium was exposed to the following stress agents: 0.1 M HCl, 0.1 M NaOH, and 3% (v/v) H2O2. The analyses of losartan potassium solutions were carried out in a gradient elution mode with acetonitrile and 0.1% (v/v) CF3COOH aqueous solution and constant flow rate of 0.5 mL min-1 within 22 min run time. After 7 days of losartan potassium solutions exposure to the stress agents at room temperature, it was found that the degree of degradation in the presence of 0.1 M HCl and 0.1 M NaOH was less than 1%, while in the presence of 3% H2O2 degradation was significantly higher (about 10%). Chemical structure elucidation of the major degradation products of losartan potassium was performed using LC-MS/MS method. The concentration versus time plot indicated that in 3% (v/v) H2O2 solution losartan potassium was degraded according to the pseudo zero-order reaction kinetics with 1.4810-8 mol L-1 day-1 rate constant. © 2019, Pharmaceutical Association of Serbia. All rights reserved. | en |
dc.publisher | Pharmaceutical Association of Serbia | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-sa/4.0/ | |
dc.source | Arhiv za farmaciju | |
dc.subject | Forced degradation | |
dc.subject | Kinetics | |
dc.subject | LC-MS/MS | |
dc.subject | Losartan potassium | |
dc.subject | Losartan kalijum | |
dc.subject | Forsirana degradacija | |
dc.subject | Kinetika | |
dc.subject | LC-MS/MS | |
dc.title | Degradation kinetics and characterization of degradation products of losartan potassium by lc-ms/ms method | en |
dc.title | Kinetika degradacije i karakterizacija degradacionih proizvoda losartan kalijuma lcms/ms metodom | sr |
dc.type | article | |
dc.rights.license | BY-SA | |
dcterms.abstract | Марковић, Бојан; Добричић, Владимир; Кинетика деградације и карактеризација деградационих производа лосартан калијума лцмс/мс методом; | |
dc.citation.volume | 69 | |
dc.citation.issue | 2 | |
dc.citation.spage | 80 | |
dc.citation.epage | 89 | |
dc.citation.rank | M52 | |
dc.identifier.doi | 10.5937/arhfarm1902080X | |
dc.identifier.scopus | 2-s2.0-85090640124 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs/bitstream/id/8075/Degradation_Kinetics_and_pub_2019.pdf | |
dc.type.version | publishedVersion |