Cyclodextrins (CDs) are widely used in pharmaceutical analysis due to its biodegradability and eco-friendly character. The particular structure of CDs, characterized by hydrophobic cavity, enables the formation of inclusion complexes with variety of organic compounds. As structures lacking chromophores, CDs could not be detected by Photodiode Array (PDA) detector and Corona Charged Aerosol Detector (CAD) was introduced as the most appropriate detector for the formed complexes. The aim of the study was to investigate the degree of complexation between telmisartan, used as a model substance, and β-CD. Moreover, the effect of different β-CD concentrations (5-15 mM) and pH of the aqueous part of mobile phase (3-7) on the degree of complexation was also assessed. The intensity of the formed complex appeared to be the highest when 15 mM β-CD was used for the complexation. Also, it was noticed that the increase in peak areas with an increasing β-CD concentration was more evident at pH 7 in co...mparison with the same trend at lower pH values. The reproducibility of the measurement was confirmed by low relative standard deviation (RSD) of peak areas within five measurements. These findings support the use of HPLC-CAD methods for studying the process of inclusion complexes formation.
TY - JOUR
AU - Maljurić, Nevena
AU - Golubović, Jelena
AU - Otašević, Biljana
AU - Krmar, Jovana
AU - Zečević, Mira
AU - Protić, Ana
PY - 2019
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3666
AB - Cyclodextrins (CDs) are widely used in pharmaceutical analysis due to its biodegradability and eco-friendly character. The particular structure of CDs, characterized by hydrophobic cavity, enables the formation of inclusion complexes with variety of organic compounds. As structures lacking chromophores, CDs could not be detected by Photodiode Array (PDA) detector and Corona Charged Aerosol Detector (CAD) was introduced as the most appropriate detector for the formed complexes. The aim of the study was to investigate the degree of complexation between telmisartan, used as a model substance, and β-CD. Moreover, the effect of different β-CD concentrations (5-15 mM) and pH of the aqueous part of mobile phase (3-7) on the degree of complexation was also assessed. The intensity of the formed complex appeared to be the highest when 15 mM β-CD was used for the complexation. Also, it was noticed that the increase in peak areas with an increasing β-CD concentration was more evident at pH 7 in comparison with the same trend at lower pH values. The reproducibility of the measurement was confirmed by low relative standard deviation (RSD) of peak areas within five measurements. These findings support the use of HPLC-CAD methods for studying the process of inclusion complexes formation.
PB - Pharmaceutical Association of Serbia
T2 - Arhiv za farmaciju
T1 - The potential of corona charged aerosol detector for investigation of telmisartan-β-cyclodextrin inclusion complexes
VL - 69
IS - 1
SP - 1
EP - 14
DO - 10.5937/arhfarm1901001M
ER -
@article{
author = "Maljurić, Nevena and Golubović, Jelena and Otašević, Biljana and Krmar, Jovana and Zečević, Mira and Protić, Ana",
year = "2019",
abstract = "Cyclodextrins (CDs) are widely used in pharmaceutical analysis due to its biodegradability and eco-friendly character. The particular structure of CDs, characterized by hydrophobic cavity, enables the formation of inclusion complexes with variety of organic compounds. As structures lacking chromophores, CDs could not be detected by Photodiode Array (PDA) detector and Corona Charged Aerosol Detector (CAD) was introduced as the most appropriate detector for the formed complexes. The aim of the study was to investigate the degree of complexation between telmisartan, used as a model substance, and β-CD. Moreover, the effect of different β-CD concentrations (5-15 mM) and pH of the aqueous part of mobile phase (3-7) on the degree of complexation was also assessed. The intensity of the formed complex appeared to be the highest when 15 mM β-CD was used for the complexation. Also, it was noticed that the increase in peak areas with an increasing β-CD concentration was more evident at pH 7 in comparison with the same trend at lower pH values. The reproducibility of the measurement was confirmed by low relative standard deviation (RSD) of peak areas within five measurements. These findings support the use of HPLC-CAD methods for studying the process of inclusion complexes formation.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "The potential of corona charged aerosol detector for investigation of telmisartan-β-cyclodextrin inclusion complexes",
volume = "69",
number = "1",
pages = "1-14",
doi = "10.5937/arhfarm1901001M"
}
Maljurić, N., Golubović, J., Otašević, B., Krmar, J., Zečević, M.,& Protić, A.. (2019). The potential of corona charged aerosol detector for investigation of telmisartan-β-cyclodextrin inclusion complexes. in Arhiv za farmaciju
Pharmaceutical Association of Serbia., 69(1), 1-14.
https://doi.org/10.5937/arhfarm1901001M
Maljurić N, Golubović J, Otašević B, Krmar J, Zečević M, Protić A. The potential of corona charged aerosol detector for investigation of telmisartan-β-cyclodextrin inclusion complexes. in Arhiv za farmaciju. 2019;69(1):1-14.
doi:10.5937/arhfarm1901001M .
Maljurić, Nevena, Golubović, Jelena, Otašević, Biljana, Krmar, Jovana, Zečević, Mira, Protić, Ana, "The potential of corona charged aerosol detector for investigation of telmisartan-β-cyclodextrin inclusion complexes" in Arhiv za farmaciju, 69, no. 1 (2019):1-14,
https://doi.org/10.5937/arhfarm1901001M . .
