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dc.creatorMaljurić, Nevena
dc.creatorGolubović, Jelena
dc.creatorOtašević, Biljana
dc.creatorKrmar, Jovana
dc.creatorZečević, Mira
dc.creatorProtić, Ana
dc.date.accessioned2020-09-22T17:04:13Z
dc.date.available2020-09-22T17:04:13Z
dc.date.issued2019
dc.identifier.issn0004-1963
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3666
dc.description.abstractCyclodextrins (CDs) are widely used in pharmaceutical analysis due to its biodegradability and eco-friendly character. The particular structure of CDs, characterized by hydrophobic cavity, enables the formation of inclusion complexes with variety of organic compounds. As structures lacking chromophores, CDs could not be detected by Photodiode Array (PDA) detector and Corona Charged Aerosol Detector (CAD) was introduced as the most appropriate detector for the formed complexes. The aim of the study was to investigate the degree of complexation between telmisartan, used as a model substance, and β-CD. Moreover, the effect of different β-CD concentrations (5-15 mM) and pH of the aqueous part of mobile phase (3-7) on the degree of complexation was also assessed. The intensity of the formed complex appeared to be the highest when 15 mM β-CD was used for the complexation. Also, it was noticed that the increase in peak areas with an increasing β-CD concentration was more evident at pH 7 in comparison with the same trend at lower pH values. The reproducibility of the measurement was confirmed by low relative standard deviation (RSD) of peak areas within five measurements. These findings support the use of HPLC-CAD methods for studying the process of inclusion complexes formation.
dc.publisherPharmaceutical Association of Serbia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172033/RS//
dc.rightsopenAccess
dc.sourceArhiv za Farmaciju
dc.subjectCorona Charged Aerosol Detector
dc.subjectInclusion complex
dc.subjectTelmisartan
dc.subjectβ-Cyclodextrin
dc.titleThe potential of corona charged aerosol detector for investigation of telmisartan-β-cyclodextrin inclusion complexes
dc.typearticle
dc.rights.licenseBY-SA
dcterms.abstractМаљурић, Невена; Оташевић, Биљана; Голубовић, Јелена; Крмар, Јована; Зечевић, Мира; Протић, Aна;
dc.citation.volume69
dc.citation.issue1
dc.citation.spage1
dc.citation.epage14
dc.citation.rankM52
dc.identifier.doi10.5937/arhfarm1901001M
dc.identifier.scopus2-s2.0-85090608793
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/8077/The_potential_of_pub_2019.pdf
dc.type.versionpublishedVersion


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