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dc.creatorIgnjatović, Jelisaveta
dc.creatorĐuriš, Jelena
dc.creatorCvijić, Sandra
dc.creatorDobričić, Vladimir
dc.creatorMontepietra, Agnese
dc.creatorLombardi, Chiara
dc.creatorIbrić, Svetlana
dc.creatorRossi, Alessandra
dc.date.accessioned2020-10-28T09:00:08Z
dc.date.available2020-10-28T09:00:08Z
dc.date.issued2021
dc.identifier.issn0928-0987
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3709
dc.description.abstractThe aim of this study was to optimize the parameters of the complex melt-emulsification process coupled with the spray-drying, in order to maintain the balance between solid lipid microparticles (SLMs) powders aerodynamic performance and salbutamol sulfate release rate. Quality target product profile was identified and risk management and principal component analysis were used to guide formulation development. Obtained dry powders for inhalation (DPIs) were evaluated in terms of SLMs size distribution, morphology, true density, drug content, solid state characterization studies, in vitro aerosol performance and in vitro drug release. SLMs micrographs indicated spherical, porous particles. Selected powders showed satisfactory aerosol performance with a mean mass aerodynamic diameter of around 3 μm and acceptable fine particle fraction (FPF). Addition of trehalose positively affected SLMs aerodynamic properties. The results of in vitro dissolution testing indicated that salbutamol sulfate release from the tested SLMs formulations was modified, in comparison to the raw drug release. In conclusion, SLMs in a form of DPIs were successfully developed and numerous factors that affects SLMs properties were identified in this study. Further research is required for full understanding of each factor's influence on SLMs properties and optimization of DPIs with maximized FPFs.en
dc.publisherElsevier B.V.
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Pharmaceutical Sciences
dc.subjectDry powders for inhalation
dc.subjectMelt-emulsification
dc.subjectQuality target product profile
dc.subjectSolid lipid microparticles
dc.subjectSpray-drying
dc.titleDevelopment of solid lipid microparticles by melt-emulsification/spray-drying processes as carriers for pulmonary drug deliveryen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДобричић, Владимир; Ђуриш, Јелена; Игњатовић, Јелисавета; Монтепиетра, Aгнесе; Ломбарди, Цхиара; Ибрић, Светлана; Цвијић, Сандра; Росси, Aлессандра;
dc.citation.volume156
dc.citation.rankM21~
dc.identifier.wos000597380300006
dc.identifier.doi10.1016/j.ejps.2020.105588
dc.identifier.scopus2-s2.0-85092729637
dc.type.versionpublishedVersion


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