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dc.creatorDimitrijević, Mirjana
dc.creatorArsenović-Ranin, Nevena
dc.creatorBufan, Biljana
dc.creatorNacka-Aleksić, Mirjana
dc.creatorKosec, Dušan
dc.creatorPilipović, Ivan
dc.creatorKotur-Stevuljević, Jelena
dc.creatorSimić, Ljubica
dc.creatorSopta, Jelena
dc.creatorLeposavić, Gordana
dc.date.accessioned2020-11-02T12:08:55Z
dc.date.available2020-11-02T12:08:55Z
dc.date.issued2020
dc.identifier.issn0360-3997
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3714
dc.description.abstractMonocytes’ plasticity has an important role in the development of rheumatoid arthritis (RA), an autoimmune disease exhibiting greater prevalence in women. Contribution of this phenomenon to sex bias in RA severity was investigated in rat collagen-induced arthritis (CIA) model of RA. The greater severity of CIA in females (exhibiting signs of bone resorption) was accompanied by the higher blood level of advanced oxidation protein products and a more pro-oxidant profile. Consistently, in females, the greater density of giant multinuclear cells (monocytes/macrophages and osteoclasts) in inflamed joint tissue was found. This correlated with the higher frequencies of CCR2- and CX3CR1- expressing cells (precursors of inflammatory monocytes/macrophages and osteoclasts) among CD11b+ splenocytes. This in conjunction with the enhanced migratory capacity of CD11b+ monocytic cells in females compared with males could be linked with the higher frequencies of CCR2+CX3CR1-CD43lowCD11b+ and CCR2-CX3CR1+CD43hiCD11b+ cells (corresponding to “classical” and “non-classical” monocytes, respectively) and the greater density of CD68+ cells (monocytes/macrophages and osteoclast precursors/osteoclasts) in blood and inflamed paws from female rats, respectively. Consistently, the higher levels of GM-CSF, TNF-α and IL-6, IL-1β (driving Th17 cell differentiation), and IL-17 followed by the lower level of IL-10 were measured in inflamed paw cultures from female compared with male rats. To the greater IL-17 production (associated with enhanced monocyte immigration and differentiation into osteoclasts) most likely contributed augmented Th17 cell generation in the lymph nodes draining arthritic joints from female compared with male rats. Overall, the study suggests the sex-specific contribution of monocytic lineage cells to CIA, and possibly RA development.en
dc.publisherSpringer Nature
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.rightsrestrictedAccess
dc.sourceInflammation
dc.subjectCCR2
dc.subjectcollagen-induced arthritis
dc.subjectCX3CR1
dc.subjectmonocytes’ plasticity
dc.subjectoxidative stress
dc.subjectsex differences
dc.titleSex-Based Differences in Monocytic Lineage Cells Contribute to More Severe Collagen-Induced Arthritis in Female Rats Compared with Male Ratsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСимић, Љубица; Димитријевић, Мирјана; Aрсеновић-Ранин, Невена; Буфан, Биљана; Нацка-Aлексић, Мирјана; Пилиповић, Иван; Котур-Стевуљевић, Јелена; Сопта, Јелена; Лепосавић, Гордана; Косец, Душан;
dc.citation.volume43
dc.citation.issue6
dc.citation.spage2312
dc.citation.epage2331
dc.citation.rankM22
dc.identifier.wos000563610900001
dc.identifier.doi10.1007/s10753-020-01302-0
dc.identifier.scopus2-s2.0-85089996658
dc.type.versionpublishedVersion


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