Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture
Redoks status i razine bioelemenata u mozgu štakora akutno izloženih smjesi kadmija i olova
Authors
Javorac, Dragana
Buha-Đorđević, Aleksandra

Anđelković, Milena

Tatović, Simona

Baralić, Katarina

Antonijević, Evica

Kotur-Stevuljević, Jelena

Đukić-Ćosić, Danijela

Antonijević, Biljana

Bulat, Zorica

Article (Published version)
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Show full item recordAbstract
Most Pb and Cd neurotoxicity studies investigate exposure to either of the toxic metals alone, while data on co-exposure are scarce. The aim of our study was to fill that gap by investigating acute combined effects of Pb and Cd on redox and essential metal status in the brain of Wistar rats. Animals were randomised in four groups of six to eight rats, which received 15 or 30 mg/kg of Cd, 150 mg/kg of Pb, or 150 mg/kg of Pb + 15 mg/kg of Cd by gavage. The fifth, control, group received distilled water only. Co-treatment with Pb and Cd induced significant increase in malondialdehyde (MDA) and thiobarbituric acid-reactive substances (TBARS) compared to control and groups receiving either metal alone. This is of special importance, as MDA presence in the brain has been implicated in many neurodegenerative disorders. The groups did not significantly differ in Zn, Cu, Mn, and Fe brain levels. Our findings highlight the importance of metal mixture studies. Neurotoxicity assessments of single ...chemicals do not provide a real insight into exposure to mixtures in real life. Further research should look into interactions between these metals to reveal complex molecular mechanisms of their neurotoxicity.
Dosadašnji podatci o neurotoksičnosti olova (Pb) i kadmija (Cd) uglavnom su opisani nakon izloženosti pojedinačnim
metalima, a podatci o neurotoksičnom djelovanju smjese tih dvaju metala prilično su oskudni. Cilj ovoga rada bio je
ispitati učinak akutnoga izlaganja smjesi olova i kadmija na parametre oksidacijskoga stresa i status bioelemenata u mozgu
štakora. Životinje su bile podijeljene u pet skupina: Cd15 (15 mg/kg), Cd30 (30 mg/kg), Pb150 (150 mg/kg), Pb150+Cd15
i kontrolna, netretirana skupina. Smjesa olova i kadmija dovela je do značajno viših vrijednosti malondialdehida (MDA)
i drugih produkata u mozgu štakora u usporedbi s kontrolnom skupinom i obama pojedinačnim metalima. To je iznimno
važno, imajući u vidu da je prisutnost MDA-a u mozgu povezana s mnogim neurodegenerativnim poremećajima. Nije
dobivena statistički značajna razlika između ispitivanih skupina u razinama cinka (Zn), bakra (Cu), mangana (Mn) i
željeza (Fe). Rezultati ovoga istraživanja važan su doprinos b...udućim istraživanjima smjesa i upućuju na to da istraživanja
toksičnosti u kojima se procjenjuje neurotoksičnost pojedinačnih kemikalija ne pružaju stvarni uvid u neurotoksičnost
njihovih smjesa kojima smo izloženi u stvarnom životu. Dobiveni rezultati otvaraju daljnja pitanja o interakciji i
mehanizmima toksičnosti smjese tih metala.
Keywords:
oxidative stress / Cd / Cu / Fe / MDA / Mn / neurotoxicity / Pb / TBARS / Zn / neurotoksičnost / oksidacijski stresSource:
Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 2020, 71, 3, 197-204Publisher:
- Sciendo
Funding / projects:
- Improvement and development of hygienic and technological procedures in production of animal originating foodstuffs with the aim of producing high-quality and safe products competetive on the global market (RS-46009)
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200161 (University of Belgrade, Faculty of Pharmacy) (RS-200161)
DOI: 10.2478/aiht-2020-71-3425
ISSN: 1848-6312
WoS: 000580588500004
Scopus: 2-s2.0-85093986855
Collections
Institution/Community
PharmacyTY - JOUR AU - Javorac, Dragana AU - Buha-Đorđević, Aleksandra AU - Anđelković, Milena AU - Tatović, Simona AU - Baralić, Katarina AU - Antonijević, Evica AU - Kotur-Stevuljević, Jelena AU - Đukić-Ćosić, Danijela AU - Antonijević, Biljana AU - Bulat, Zorica PY - 2020 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3715 AB - Most Pb and Cd neurotoxicity studies investigate exposure to either of the toxic metals alone, while data on co-exposure are scarce. The aim of our study was to fill that gap by investigating acute combined effects of Pb and Cd on redox and essential metal status in the brain of Wistar rats. Animals were randomised in four groups of six to eight rats, which received 15 or 30 mg/kg of Cd, 150 mg/kg of Pb, or 150 mg/kg of Pb + 15 mg/kg of Cd by gavage. The fifth, control, group received distilled water only. Co-treatment with Pb and Cd induced significant increase in malondialdehyde (MDA) and thiobarbituric acid-reactive substances (TBARS) compared to control and groups receiving either metal alone. This is of special importance, as MDA presence in the brain has been implicated in many neurodegenerative disorders. The groups did not significantly differ in Zn, Cu, Mn, and Fe brain levels. Our findings highlight the importance of metal mixture studies. Neurotoxicity assessments of single chemicals do not provide a real insight into exposure to mixtures in real life. Further research should look into interactions between these metals to reveal complex molecular mechanisms of their neurotoxicity. AB - Dosadašnji podatci o neurotoksičnosti olova (Pb) i kadmija (Cd) uglavnom su opisani nakon izloženosti pojedinačnim metalima, a podatci o neurotoksičnom djelovanju smjese tih dvaju metala prilično su oskudni. Cilj ovoga rada bio je ispitati učinak akutnoga izlaganja smjesi olova i kadmija na parametre oksidacijskoga stresa i status bioelemenata u mozgu štakora. Životinje su bile podijeljene u pet skupina: Cd15 (15 mg/kg), Cd30 (30 mg/kg), Pb150 (150 mg/kg), Pb150+Cd15 i kontrolna, netretirana skupina. Smjesa olova i kadmija dovela je do značajno viših vrijednosti malondialdehida (MDA) i drugih produkata u mozgu štakora u usporedbi s kontrolnom skupinom i obama pojedinačnim metalima. To je iznimno važno, imajući u vidu da je prisutnost MDA-a u mozgu povezana s mnogim neurodegenerativnim poremećajima. Nije dobivena statistički značajna razlika između ispitivanih skupina u razinama cinka (Zn), bakra (Cu), mangana (Mn) i željeza (Fe). Rezultati ovoga istraživanja važan su doprinos budućim istraživanjima smjesa i upućuju na to da istraživanja toksičnosti u kojima se procjenjuje neurotoksičnost pojedinačnih kemikalija ne pružaju stvarni uvid u neurotoksičnost njihovih smjesa kojima smo izloženi u stvarnom životu. Dobiveni rezultati otvaraju daljnja pitanja o interakciji i mehanizmima toksičnosti smjese tih metala. PB - Sciendo T2 - Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology T1 - Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture T1 - Redoks status i razine bioelemenata u mozgu štakora akutno izloženih smjesi kadmija i olova VL - 71 IS - 3 SP - 197 EP - 204 DO - 10.2478/aiht-2020-71-3425 ER -
@article{ author = "Javorac, Dragana and Buha-Đorđević, Aleksandra and Anđelković, Milena and Tatović, Simona and Baralić, Katarina and Antonijević, Evica and Kotur-Stevuljević, Jelena and Đukić-Ćosić, Danijela and Antonijević, Biljana and Bulat, Zorica", year = "2020", abstract = "Most Pb and Cd neurotoxicity studies investigate exposure to either of the toxic metals alone, while data on co-exposure are scarce. The aim of our study was to fill that gap by investigating acute combined effects of Pb and Cd on redox and essential metal status in the brain of Wistar rats. Animals were randomised in four groups of six to eight rats, which received 15 or 30 mg/kg of Cd, 150 mg/kg of Pb, or 150 mg/kg of Pb + 15 mg/kg of Cd by gavage. The fifth, control, group received distilled water only. Co-treatment with Pb and Cd induced significant increase in malondialdehyde (MDA) and thiobarbituric acid-reactive substances (TBARS) compared to control and groups receiving either metal alone. This is of special importance, as MDA presence in the brain has been implicated in many neurodegenerative disorders. The groups did not significantly differ in Zn, Cu, Mn, and Fe brain levels. Our findings highlight the importance of metal mixture studies. Neurotoxicity assessments of single chemicals do not provide a real insight into exposure to mixtures in real life. Further research should look into interactions between these metals to reveal complex molecular mechanisms of their neurotoxicity., Dosadašnji podatci o neurotoksičnosti olova (Pb) i kadmija (Cd) uglavnom su opisani nakon izloženosti pojedinačnim metalima, a podatci o neurotoksičnom djelovanju smjese tih dvaju metala prilično su oskudni. Cilj ovoga rada bio je ispitati učinak akutnoga izlaganja smjesi olova i kadmija na parametre oksidacijskoga stresa i status bioelemenata u mozgu štakora. Životinje su bile podijeljene u pet skupina: Cd15 (15 mg/kg), Cd30 (30 mg/kg), Pb150 (150 mg/kg), Pb150+Cd15 i kontrolna, netretirana skupina. Smjesa olova i kadmija dovela je do značajno viših vrijednosti malondialdehida (MDA) i drugih produkata u mozgu štakora u usporedbi s kontrolnom skupinom i obama pojedinačnim metalima. To je iznimno važno, imajući u vidu da je prisutnost MDA-a u mozgu povezana s mnogim neurodegenerativnim poremećajima. Nije dobivena statistički značajna razlika između ispitivanih skupina u razinama cinka (Zn), bakra (Cu), mangana (Mn) i željeza (Fe). Rezultati ovoga istraživanja važan su doprinos budućim istraživanjima smjesa i upućuju na to da istraživanja toksičnosti u kojima se procjenjuje neurotoksičnost pojedinačnih kemikalija ne pružaju stvarni uvid u neurotoksičnost njihovih smjesa kojima smo izloženi u stvarnom životu. Dobiveni rezultati otvaraju daljnja pitanja o interakciji i mehanizmima toksičnosti smjese tih metala.", publisher = "Sciendo", journal = "Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology", title = "Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture, Redoks status i razine bioelemenata u mozgu štakora akutno izloženih smjesi kadmija i olova", volume = "71", number = "3", pages = "197-204", doi = "10.2478/aiht-2020-71-3425" }
Javorac, D., Buha-Đorđević, A., Anđelković, M., Tatović, S., Baralić, K., Antonijević, E., Kotur-Stevuljević, J., Đukić-Ćosić, D., Antonijević, B.,& Bulat, Z.. (2020). Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology Sciendo., 71(3), 197-204. https://doi.org/10.2478/aiht-2020-71-3425
Javorac D, Buha-Đorđević A, Anđelković M, Tatović S, Baralić K, Antonijević E, Kotur-Stevuljević J, Đukić-Ćosić D, Antonijević B, Bulat Z. Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology. 2020;71(3):197-204. doi:10.2478/aiht-2020-71-3425 .
Javorac, Dragana, Buha-Đorđević, Aleksandra, Anđelković, Milena, Tatović, Simona, Baralić, Katarina, Antonijević, Evica, Kotur-Stevuljević, Jelena, Đukić-Ćosić, Danijela, Antonijević, Biljana, Bulat, Zorica, "Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture" in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 71, no. 3 (2020):197-204, https://doi.org/10.2478/aiht-2020-71-3425 . .